L1TD1

L1TD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LR6, 3SOO
Identifiers
Aliases	L1TD1 , ECAT11, LINE-1 type transposase domain containing 1, LINE1 type transposase domain containing 1
External IDs	MGI: 3578435; HomoloGene: 136289; GeneCards: L1TD1; OMA:L1TD1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p31.3 Start 62,194,849 bp [1] End 62,212,328 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 C6 Start 98,614,971 bp [2] End 98,626,717 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle placenta appendix mucosa of transverse colon white blood cell monocyte right testis left testis epithelium of colon Top expressed in yolk sac epiblast embryo blastocyst blastocyst primitive streak morula embryo tail of embryo hand More reference expression data BioGPS More reference expression data
Gene ontology Molecular function single-stranded RNA binding protein binding Cellular component ribonucleoprotein complex Biological process transposition, RNA-mediated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54596 381591 Ensembl ENSG00000240563 ENSMUSG00000087166 UniProt Q5T7N2 Q587J6 RefSeq (mRNA) NM_019079 NM_001164835 NM_001081202 RefSeq (protein) NP_001158307 NP_061952 NP_001074671 Location (UCSC) Chr 1: 62.19 – 62.21 Mb Chr 4: 98.61 – 98.63 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

LINE-1 type transposase domain containing 1, also known as L1TD1, is an RNA-binding protein that involved with self-renewal of undifferentiated human embryonic stem cells and cancer cell proliferation. L1TD1 has been reported to associate with the development of several cancers. ^{[5] [6] [7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000240563 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000087166 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Iwabuchi KA, Yamakawa T, Sato Y, Ichisaka T, Takahashi K, Okita K, Yamanaka S (May 2011). "ECAT11/L1td1 is enriched in ESCs and rapidly activated during iPSC generation, but it is dispensable for the maintenance and induction of pluripotency". PLOS ONE. 6 (5) e20461. Bibcode:2011PLoSO...620461I. doi: 10.1371/journal.pone.0020461 . PMC   3102727 . PMID   21637830.
6. Närvä E, Rahkonen N, Emani MR, Lund R, Pursiheimo JP, Nästi J, Autio R, Rasool O, Denessiouk K, Lähdesmäki H, Rao A, Lahesmaa R (March 2012). "RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation". Stem Cells. 30 (3): 452–60. doi:10.1002/stem.1013. PMC   3507993 . PMID   22162396.
7. Wong RC, Ibrahim A, Fong H, Thompson N, Lock LF, Donovan PJ (April 2011). "L1TD1 is a marker for undifferentiated human embryonic stem cells". PLOS ONE. 6 (4) e19355. Bibcode:2011PLoSO...619355W. doi: 10.1371/journal.pone.0019355 . PMC   3084827 . PMID   21559406.
8. Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y (October 2008). "LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis" . Cancer Epidemiol Biomarkers Prev. 17 (10): 2555–64. doi:10.1158/1055-9965.EPI-08-0112. PMID   18842996. S2CID   24719399.

Further reading

• Mitsui K, Tokuzawa Y, Itoh H, et al. (2003). "The homeoprotein Nanog isrequired for maintenance of pluripotency in mouse epiblast and ES cells". Cell. 113 (5): 631–42. doi: 10.1016/S0092-8674(03)00393-3 . PMID   12787504. S2CID   18836242.
• Cash HL, Tao L, Yuan JM, et al. (2012). "LINE-1 hypomethylation is associated with bladder cancer risk among nonsmoking Chinese". Int J Cancer. 130 (5): 1151–9. doi:10.1002/ijc.26098. PMC   3208798 . PMID   21445976.