LARS2

LARS2
Identifiers
Aliases	LARS2 , LEURS, PRLTS4, mtLeuRS, leucyl-tRNA synthetase 2, mitochondrial, HLASA
External IDs	OMIM: 604544; MGI: 2142973; HomoloGene: 6526; GeneCards: LARS2; OMA:LARS2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p21.31 Start 45,388,561 bp [1] End 45,554,726 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9 F4|9 73.92 cM Start 123,195,992 bp [2] End 123,291,731 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone oocyte secondary oocyte Brodmann area 23 mucosa of transverse colon kidney tubule caudate nucleus retinal pigment epithelium prefrontal cortex ganglionic eminence Top expressed in zygote yolk sac lip superior frontal gyrus spermatocyte muscle of thigh tail of embryo ventricular zone genital tubercle neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function aminoacyl-tRNA ligase activity nucleotide binding ligase activity ATP binding aminoacyl-tRNA editing activity leucine-tRNA ligase activity Cellular component mitochondrial matrix mitochondrion Biological process tRNA aminoacylation for protein translation protein biosynthesis leucyl-tRNA aminoacylation mitochondrial translation aminoacyl-tRNA metabolism involved in translational fidelity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23395 102436 Ensembl ENSG00000011376 ENSMUSG00000035202 UniProt Q15031 Q8VDC0 RefSeq (mRNA) NM_015340 NM_001368263 NM_153168 NM_001348167 NM_001348168 RefSeq (protein) NP_056155 NP_001355192 NP_694808 NP_001335096 NP_001335097 Location (UCSC) Chr 3: 45.39 – 45.55 Mb Chr 9: 123.2 – 123.29 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable leucyl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the LARS2 gene. ^{[5] [6]}

This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000011376 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035202 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sohm B, Sissler M, Park H, King MP, Florentz C (May 2004). "Recognition of human mitochondrial tRNALeu(UUR) by its cognate leucyl-tRNA synthetase". J Mol Biol. 339 (1): 17–29. doi:10.1016/j.jmb.2004.03.066. PMID   15123417.
6. "Entrez Gene: LARS2 leucyl-tRNA synthetase 2, mitochondrial".

Further reading

• Olsson P, Wennberg AL (1992). "[Midwife and research. Conference report]". Jordemodern. 104 (11): 408–9, 404. PMID   1684970.
• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi: 10.1093/dnares/1.1.27 . PMID   7584026.
• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi: 10.1093/dnares/1.1.47 . PMID   7584028.
• Szeles A, Yang Y, Sandlund AM, et al. (1998). "Human/mouse microcell hybrid based elimination test reduces the putative tumor suppressor region at 3p21.3 to 1.6 cM". Genes Chromosomes Cancer. 20 (4): 329–36. doi:10.1002/(SICI)1098-2264(199712)20:4<329::AID-GCC3>3.0.CO;2-3. PMID   9408748. S2CID   39132097.
• Kiss H, Kedra D, Yang Y, et al. (2000). "A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3". Hum. Genet. 105 (6): 552–9. doi:10.1007/s004399900188. PMID   10647888.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Yao YN, Wang L, Wu XF, Wang ED (2004). "The processing of human mitochondrial leucyl-tRNA synthetase in the insect cells". FEBS Lett. 534 (1–3): 139–42. doi: 10.1016/S0014-5793(02)03833-4 . PMID   12527375. S2CID   21901003.
• Park H, Davidson E, King MP (2003). "The pathogenic A3243G mutation in human mitochondrial tRNALeu(UUR) decreases the efficiency of aminoacylation". Biochemistry. 42 (4): 958–64. doi:10.1021/bi026882r. PMID   12549915.
• Yao YN, Wang L, Wu XF, Wang ED (2004). "Human mitochondrial leucyl-tRNA synthetase with high activity produced from Escherichia coli". Protein Expr. Purif. 30 (1): 112–6. doi:10.1016/S1046-5928(03)00097-4. PMID   12821328.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Munakata K, Iwamoto K, Bundo M, Kato T (2005). "Mitochondrial DNA 3243A>G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia". Biol. Psychiatry. 57 (5): 525–32. doi:10.1016/j.biopsych.2004.11.041. PMID   15737668. S2CID   28499960.
• 't Hart LM, Hansen T, Rietveld I, et al. (2005). "Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene". Diabetes. 54 (6): 1892–5. doi: 10.2337/diabetes.54.6.1892 . hdl: 1765/10387 . PMID   15919814.