LIPH (gene)

LIPH
Identifiers
Aliases	LIPH , AH, ARWH2, HYPT7, LAH2, LPDLR, PLA1B, mPA-PLA1, lipase H
External IDs	OMIM: 607365 MGI: 2388029 HomoloGene: 71802 GeneCards: LIPH
Gene location (Human)
Chr.	Chromosome 3 (human)
End	185,552,588 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	21,814,413 bp
RNA expression pattern
	Top expressed in
	rectum; ; pancreatic ductal cell; ; islet of Langerhans; ; amniotic fluid; ; palpebral conjunctiva; ; gallbladder; ; minor salivary gland; ; right lung; ; body of stomach; ; upper lobe of left lung;
	Top expressed in
	epithelium of stomach; ; duodenum; ; otolith organ; ; ileum; ; utricle; ; right lung lobe; ; left colon; ; jejunum; ; conjunctival fornix; ; left lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	heparin binding ; carboxylic ester hydrolase activity ; hydrolase activity ; phospholipase activity ; lipase activity ;
Cellular component	extracellular region ; plasma membrane ; membrane ; extracellular space ;
Biological process	lipid catabolic process ; lipid metabolism ; phosphatidic acid biosynthetic process ;
	Sources:Amigo / QuickGO
Orthologs
	200879
	239759
	ENSG00000163898
	ENSMUSG00000044626
	Q8WWY8
	Q8CIV3
	NM_139248
	NM_001083894 ; NM_001289581 ; NM_001289582 ; NM_153404
	NP_640341
	NP_001077363 ; NP_001276510 ; NP_001276511 ; NP_700453
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 19, 2023

Lipase member H is an enzyme that in humans is encoded by the LIPH gene.^[5]^[6]^[7]

This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility.^[7]

Related Research Articles

Lysophosphatidic acid receptor 2 also known as LPA₂ is a protein that in humans is encoded by the LPAR2 gene. LPA₂ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

Lysophosphatidic acid receptor 6, also known as LPA₆, P2RY5 and GPR87, is a protein that in humans is encoded by the LPAR6 gene. LPA₆ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

HR is a gene encoding Protein hairless.

Transmembrane protease, serine 3 is an enzyme that in humans is encoded by the TMPRSS3 gene.

Lipid phosphate phosphohydrolase 1 also known as phosphatidic acid phosphatase 2a is an enzyme that in humans is encoded by the PPAP2A gene.

Keratocan (KTN) also known as keratan sulfate proteoglycan keratocan, is a protein that in humans is encoded by the KERA gene.

Lipid phosphate phosphohydrolase 2 is an enzyme that in humans is encoded by the PPAP2C gene.

TRIO and F-actin-binding protein is a protein that in humans is encoded by the TRIOBP gene.

Tubby-related protein 1 is a protein that in humans is encoded by the TULP1 gene.

Sodium bicarbonate transporter-like protein 11 is a protein that in humans is encoded by the SLC4A11 gene.

1-acyl-sn-glycerol-3-phosphate acyltransferase alpha is an enzyme that in humans is encoded by the AGPAT1 gene.

Optic atrophy 3 protein is a protein that in humans is encoded by the OPA3 gene.

Myotubularin-related protein 13 is a protein that in humans is encoded by the SBF2 gene.

1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon is an enzyme that in humans is encoded by the AGPAT5 gene.

Delta-like 3 (Drosophila), also known as DLL3, is a protein which in humans is encoded by the DLL3 gene. Two transcript variants encoding distinct isoforms have been identified for this gene.

Desmoglein-4 is a protein that in humans is encoded by the DSG4 gene.

Maspardin is a protein that in humans is encoded by the SPG21 gene.

SEC23-interacting protein is a protein that in humans is encoded by the SEC23IP gene.

Ribonuclease H2 subunit A, also known as RNase H2 subunit A, is an enzyme that in humans is encoded by the RNASEH2A gene.

WD repeat-containing protein 72 is a protein that in humans is encoded by the WDR72 gene. WDR72 contains 7 WD40 repeats, which are predicted to form the blades of a 7 beta propeller structure.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163898 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044626 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Jin W, Broedl UC, Monajemi H, Glick JM, Rader DJ (Sep 2002). "Lipase H, a new member of the triglyceride lipase family synthesized by the intestine". Genomics. 80 (3): 268–73. doi:10.1006/geno.2002.6837. PMID 12213196.
↑ Sonoda H, Aoki J, Hiramatsu T, Ishida M, Bandoh K, Nagai Y, Taguchi R, Inoue K, Arai H (Sep 2002). "A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid". J Biol Chem. 277 (37): 34254–63. doi: 10.1074/jbc.M201659200 . PMID 12063250.
1 2 "Entrez Gene: LIPH lipase, member H".

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Wen XY, Hegele RA, Wang J, et al. (2004). "Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans". Hum. Mol. Genet. 12 (10): 1131–43. doi: 10.1093/hmg/ddg124 . PMID 12719377.
Hiramatsu T, Sonoda H, Takanezawa Y, et al. (2004). "Biochemical and molecular characterization of two phosphatidic acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta". J. Biol. Chem. 278 (49): 49438–47. doi:10.1074/jbc.M213018200. PMID 12963729.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Aslam M, Chahrour MH, Razzaq A, et al. (2005). "A novel locus for autosomal recessive form of hypotrichosis maps to chromosome 3q26.33–q27.3". J. Med. Genet. 41 (11): 849–52. doi:10.1136/jmg.2004.019729. PMC 1735610 . PMID 15520410.
Kazantseva A, Goltsov A, Zinchenko R, et al. (2006). "Human hair growth deficiency is linked to a genetic defect in the phospholipase gene LIPH". Science. 314 (5801): 982–5. Bibcode:2006Sci...314..982K. doi:10.1126/science.1133276. PMID 17095700. S2CID 17395376.
Ali G, Chishti MS, Raza SI, et al. (2007). "A mutation in the lipase H (LIPH) gene underlie autosomal recessive hypotrichosis". Hum. Genet. 121 (3–4): 319–25. doi:10.1007/s00439-007-0344-0. PMID 17333281. S2CID 9640640.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163898 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044626 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12213196-5] Jin W, Broedl UC, Monajemi H, Glick JM, Rader DJ (Sep 2002). "Lipase H, a new member of the triglyceride lipase family synthesized by the intestine". Genomics. 80 (3): 268–73. doi:10.1006/geno.2002.6837. PMID 12213196.

[pmid12063250-6] Sonoda H, Aoki J, Hiramatsu T, Ishida M, Bandoh K, Nagai Y, Taguchi R, Inoue K, Arai H (Sep 2002). "A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid". J Biol Chem. 277 (37): 34254–63. doi: 10.1074/jbc.M201659200 . PMID 12063250.

[entrez-7] 1 2 "Entrez Gene: LIPH lipase, member H".

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LIPH (gene)

Related Research Articles

References

Further reading