LRIT3

Last updated
LRIT3
Identifiers
Aliases LRIT3 , CSNB1F, FIGLER4, leucine-rich repeat, Ig-like and transmembrane domains 3, leucine rich repeat, Ig-like and transmembrane domains 3
External IDs MGI: 2685267 HomoloGene: 19426 GeneCards: LRIT3
Gene location (Human)
Ideogram human chromosome 4.svg
Chr. Chromosome 4 (human) [1]
Human chromosome 4 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 4q25Start109,848,202 bp [1]
End109,872,315 bp [1]
Orthologs
SpeciesHumanMouse
Entrez

345193

242235

Ensembl

ENSG00000183423

ENSMUSG00000093865

UniProt

Q3SXY7

W8DXL4

RefSeq (mRNA)

NM_198506

NM_001205102
NM_001287224

RefSeq (protein)

NP_940908

NP_001274153

Location (UCSC) Chr 4: 109.85 – 109.87 Mb Chr 3: 129.79 – 129.8 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 is a protein that in humans is encoded by the LRIT3 gene. [5]

Protein biological molecule consisting of chains of amino acid residues

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity.

Gene basic physical and functional unit of heredity

In biology, a gene is a sequence of nucleotides in DNA or RNA that codes for a molecule that has a function. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic trait. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes as well as gene–environment interactions. Some genetic traits are instantly visible, such as eye color or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that constitute life.

Related Research Articles

SLITRK1 protein-coding gene in the species Homo sapiens

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NALP3 protein-coding gene in the species Homo sapiens

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LRRTM1 protein-coding gene in the species Homo sapiens

LRRTM1 is a brain-expressed imprinted gene that encodes a leucine-rich repeat transmembrane protein that interacts with neurexins and neuroligins to modulate synaptic cell adhesion in neurons. As the name implies, its protein product is a transmembrane protein that contains many leucine rich repeats. It is expressed during the development of specific forebrain structures and shows a variable pattern of maternal downregulation.

LGR6 protein-coding gene in the species Homo sapiens

Leucine-rich repeat-containing G-protein coupled receptor 6 is a protein that in humans is encoded by the LGR6 gene. Along with the other G-protein coupled receptors LGR4 and LGR5, LGR6 is a Wnt signaling pathway mediator. LGR6 also acts as an epithelial stem cell marker in squamous cell carcinoma in mice in vivo.

NLRC4 protein-coding gene in the species Homo sapiens

NLR family CARD domain-containing protein 4 is a protein that in humans is encoded by the NLRC4 gene.

KDM2A protein-coding gene in the species Homo sapiens

Lysine-specific demethylase 2A (KDM2A) also known as F-box and leucine-rich repeat protein 11 (FBXL11) is an enzyme that in humans is encoded by the KDM2A gene. KDM2A is a member of the superfamily of alpha-ketoglutarate-dependent hydroxylases, which are non-haem iron-containing proteins.

LRRFIP1 protein-coding gene in the species Homo sapiens

Leucine-rich repeat flightless-interacting protein 1 is a protein that in humans is encoded by the LRRFIP1 gene.

LRIG1 protein-coding gene in the species Homo sapiens

Leucine-rich repeats and immunoglobulin-like domains protein 1 is a protein that in humans is encoded by the LRIG1 gene. It encodes a transmembrane protein that has been shown to interact with receptor tyrosine kinases of the EGFR-family , MET and RET.

LILRB3 protein-coding gene in the species Homo sapiens

Leukocyte immunoglobulin-like receptor subfamily B member 3 is a protein that in humans is encoded by the LILRB3 gene.

LRRC41 protein-coding gene in the species Homo sapiens

Leucine-rich repeat-containing protein 41 is a protein that in humans is encoded by the LRRC41 gene.

SHANK3 protein-coding gene in the species Homo sapiens

SH3 and multiple ankyrin repeat domains 3 (Shank3), also known as proline-rich synapse-associated protein 2 (ProSAP2), is a protein that in humans is encoded by the SHANK3 gene on chromosome 22. Additional isoforms have been described for this gene but they have not yet been experimentally verified.

LRRC39 protein-coding gene in the species Homo sapiens

Leucine-rich repeat-containing protein 39 is a protein that in humans is encoded by the LRRC39 gene.

FLRT2 protein-coding gene in the species Homo sapiens

Fibronectin leucine-rich repeat transmembrane protein FLRT2 is a protein that in humans is encoded by the FLRT2 gene.

LRRC17 protein-coding gene in the species Homo sapiens

Leucine-rich repeat-containing protein 17 is a protein that in humans is encoded by the LRRC17 gene.

TMC8 protein-coding gene in the species Homo sapiens

Transmembrane channel-like 8 is a protein which in humans is encoded by the TMC8 gene.

NLRC3 protein-coding gene in the species Homo sapiens

NLRC3, short for NOD-like receptor family CARD domain containing 3, is an intracellular protein that plays a role in the immune system. It was previously known as nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3 (NOD3) and CLR16.2. NLRC3 inhibits the activity of T cells.

LRRC16A protein-coding gene in the species Homo sapiens

Leucine rich repeat containing 16A is a protein that in humans is encoded by the LRRC16A gene. The gene is also known as LRRC16, CARMIL, CARMIL1 or CARMIL1a.

FBXL4 protein-coding gene in the species Homo sapiens

F-box and leucine-rich repeat protein 4 is a protein that in humans is encoded by the FBXL4 gene.

LRTOMT protein-coding gene in the species Homo sapiens

Leucine rich transmembrane and O-methyltransferase domain containing is a protein that in humans is encoded by the LRTOMT gene.

LRRC24 protein-coding gene in the species Homo sapiens

Leucine rich repeat containing 24 is a protein that, in humans, is encoded by the LRRC24 gene. The protein is represented by the official symbol LRRC24, and is alternatively known as LRRC14OS. The function of LRRC24 is currently unknown. It is a member of the leucine-rich repeat (LRR) superfamily of proteins.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000183423 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000093865 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: Leucine-rich repeat, immunoglobulin-like and transmembrane domains 3".

Further reading

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