LSM10

Last updated
LSM10
Identifiers
Aliases LSM10 , MST074, MSTP074, U7 small nuclear RNA associated
External IDs MGI: 2151045 HomoloGene: 13154 GeneCards: LSM10
Gene location (Human)
Ideogram human chromosome 1.svg
Chr. Chromosome 1 (human) [1]
Human chromosome 1 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 1p34.3Start36,391,238 bp [1]
End36,397,892 bp [1]
Orthologs
SpeciesHumanMouse
Entrez

84967

116748

Ensembl

ENSG00000181817

ENSMUSG00000050188

UniProt

Q969L4

Q8QZX5

RefSeq (mRNA)

NM_032881

NM_001163266
NM_138721

RefSeq (protein)

NP_116270

NP_001156738
NP_620046

Location (UCSC) Chr 1: 36.39 – 36.4 Mb Chr 4: 126.1 – 126.1 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

U7 snRNA-associated Sm-like protein LSm10 is a protein that in humans is encoded by the LSM10 gene. [5] [6]

Protein biological molecule consisting of chains of amino acid residues

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity.

Gene basic physical and functional unit of heredity

In biology, a gene is a sequence of nucleotides in DNA or RNA that codes for a molecule that has a function. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic trait. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes as well as gene–environment interactions. Some genetic traits are instantly visible, such as eye color or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that constitute life.

Contents

Interactions

LSM10 has been shown to interact with LSM3. [7] [8]

LSM3 protein-coding gene in the species Homo sapiens

U6 snRNA-associated Sm-like protein LSm3 is a protein that in humans is encoded by the LSM3 gene.

See also

Related Research Articles

snRNPs, or small nuclear ribonucleoproteins, are RNA-protein complexes that combine with unmodified pre-mRNA and various other proteins to form a spliceosome, a large RNA-protein molecular complex upon which splicing of pre-mRNA occurs. The action of snRNPs is essential to the removal of introns from pre-mRNA, a critical aspect of post-transcriptional modification of RNA, occurring only in the nucleus of eukaryotic cells. Additionally, U7 snRNP is not involved in splicing at all, as U7 snRNP is responsible for processing the 3′ stem-loop of histone pre-mRNA.

Small nuclear ribonucleic acid (snRNA) is a class of small RNA molecules that are found within the splicing speckles and Cajal bodies of the cell nucleus in eukaryotic cells. The length of an average snRNA is approximately 150 nucleotides. They are transcribed by either RNA polymerase II or RNA polymerase III. Their primary function is in the processing of pre-messenger RNA (hnRNA) in the nucleus. They have also been shown to aid in the regulation of transcription factors or RNA polymerase II, and maintaining the telomeres.

LSm

In molecular biology, LSm proteins are a family of RNA-binding proteins found in virtually every cellular organism. LSm is a contraction of 'like Sm', because the first identified members of the LSm protein family were the Sm proteins. LSm proteins are defined by a characteristic three-dimensional structure and their assembly into rings of six or seven individual LSm protein molecules, and play a large number of various roles in mRNA processing and regulation.

Histone 3 UTR stem-loop

The histone 3' UTR stem-loop is an RNA element involved in nucleocytoplasmic transport of the histone mRNAs, and in the regulation of stability and of translation efficiency in the cytoplasm. The mRNAs of metazoan histone genes lack polyadenylation and a poly-A tail, instead 3' end processing occurs at a site between this highly conserved stem-loop and a purine rich region around 20 nucleotides downstream. The stem-loop is bound by a 31 kDa stem-loop binding protein. Together with U7 snRNA binding of the HDE, SLBP binding nucleates the formation of the processing complex.

U7 small nuclear RNA

The U7 small nuclear RNA is an RNA molecule and a component of the small nuclear ribonucleoprotein complex. The U7 snRNA is required for histone pre-mRNA processing.

5-3 exoribonuclease 2 protein-coding gene in the species Homo sapiens

5'-3' Exoribonuclease 2 (XRN2) also known as Dhm1-like protein is an exoribonuclease enzyme that in humans is encoded by the XRN2 gene.

SLBP protein-coding gene in the species Homo sapiens

Histone RNA hairpin-binding protein or stem-loop binding protein (SLBP) is a protein that in humans is encoded by the SLBP gene.

Small nuclear ribonucleoprotein polypeptide F protein-coding gene in the species Homo sapiens

Small nuclear ribonucleoprotein F is a protein that in humans is encoded by the SNRPF gene.

STRAP protein-coding gene in the species Homo sapiens

Serine-threonine kinase receptor-associated protein is an enzyme that in humans is encoded by the STRAP gene.

LSM6 protein-coding gene in the species Homo sapiens

U6 snRNA-associated Sm-like protein LSm6 is a protein that in humans is encoded by the LSM6 gene.

LSM5 protein-coding gene in the species Homo sapiens

U6 snRNA-associated Sm-like protein LSm5 is a protein that in humans is encoded by the LSM5 gene.

LSM4 protein-coding gene in the species Homo sapiens

U6 snRNA-associated Sm-like protein LSm4 is a protein that in humans is encoded by the LSM4 gene.

LSM1 protein-coding gene in the species Homo sapiens

U6 snRNA-associated Sm-like protein LSm1 is a protein that in humans is encoded by the LSM1 gene.

LSM7 protein-coding gene in the species Homo sapiens

U6 snRNA-associated Sm-like protein LSm7 is a protein that in humans is encoded by the LSM7 gene.

LSM2 protein-coding gene in the species Homo sapiens

U6 snRNA-associated Sm-like protein LSm2 is a protein that in humans is encoded by the LSM2 gene.

40S ribosomal protein S20 protein-coding gene in the species Homo sapiens

40S ribosomal protein S20 is a protein that in humans is encoded by the RPS20 gene.

LSM8 protein-coding gene in the species Homo sapiens

U6 snRNA-associated Sm-like protein LSm8 is a protein that in humans is encoded by the LSM8 gene.

KIAA0182 protein-coding gene in the species Homo sapiens

Genetic suppressor element 1 is a protein that in humans is encoded by the KIAA0182 gene.

ZNF473 protein-coding gene in the species Homo sapiens

Zinc finger protein 473 is a protein that in humans is encoded by the ZNF473 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000181817 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050188 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Pillai RS, Will CL, Lührmann R, Schümperli D, Müller B (Oct 2001). "Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein" (PDF). The EMBO Journal. 20 (19): 5470–9. doi:10.1093/emboj/20.19.5470. PMC   125645 . PMID   11574479.
  6. ↑ "Entrez Gene: LSM10 LSM10, U7 small nuclear RNA associated".
  7. ↑ Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.
  8. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID   16189514.

Further reading

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