Late embryogenesis abundant proteins

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Late embryogenesis abundant proteins (LEA proteins) are proteins in plants, and some bacteria and invertebrates, that protect against protein aggregation due to desiccation or osmotic stresses associated with low temperature. [1] [2] [3] LEA proteins were initially discovered accumulating late in embryogenesis of cotton seeds. [4] Although abundant in seeds and pollens, LEA proteins have been found to protect against desiccation, cold, or high salinity in a variety of organisms, including the bacterium Deinococcus radiodurans , nematode Caenorhabditis elegans , Artemia (brine shrimp), and rotifers. [5] [6] [2]

Contents

Function

LEA proteins function by mechanisms which are distinct from those displayed by heat shock molecular chaperones. [1] Although the causes of LEA protein induction have not yet been determined, conformational changes in transcription factors or integral membrane proteins due to water loss have been suggested. [7] LEA proteins are particularly protective of mitochondrial membranes against dehydration damage. [8]

See also

References

  1. 1 2 Goyal, K., Walton, L. J., & Tunnacliffe, A. (2005). "LEA proteins prevent protein aggregation due to water stress". Biochemical Journal. 388 (Part 1): 151–157. doi:10.1042/BJ20041931. PMC   1186703 . PMID   15631617.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. 1 2 Hundertmark M, Hincha DK (2008). "LEA (late embryogenesis abundant) proteins and their encoding genes in Arabidopsis thaliana". BMC Genomics. 9: 118. doi: 10.1186/1471-2164-9-118 . PMC   2292704 . PMID   18318901.
  3. ↑ Liu, Y; Chakrabortee, S; Li, R; Zheng, Y; Tunnacliffe, A (18 February 2011). "Both plant and animal LEA proteins act as kinetic stabilisers of polyglutamine-dependent protein aggregation". FEBS Letters. 585 (4): 630–4. Bibcode:2011FEBSL.585..630L. doi:10.1016/j.febslet.2011.01.020. PMID   21251910. S2CID   23589368.
  4. ↑ Dure L 3rd, Greenway SC, Galau GA (1981). "Developmental biochemistry of cottonseed embryogenesis and germination: changing messenger ribonucleic acid populations as shown by in vitro and in vivo protein synthesis". Biochemistry. 20 (14): 4162–4168. doi:10.1021/bi00517a033. PMID   7284317.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: numeric names: authors list (link)
  5. ↑ Gal TZ, Glazer I, Koltai H (2004). "An LEA group 3 family member is involved in survival of C. elegans during exposure to stress". FEBS Letters. 577 (1–2): 21–26. Bibcode:2004FEBSL.577...21G. doi: 10.1016/j.febslet.2004.09.049 . PMID   15527756. S2CID   21960486.
  6. ↑ Menze MA, Boswell L, Toner M, Hand SC (2009). "Occurrence of mitochondria-targeted Late Embryogenesis Abundant (LEA) gene in animals increases organelle resistance to water stress". Journal of Biological Chemistry. 284 (16): 10714–10719. doi: 10.1074/jbc.C900001200 . PMC   2667758 . PMID   19228698.
  7. ↑ Caramelo JJ, Iusem ND (2009). "When cells lose water: Lessons from biophysics and molecular biology". Progress in Biophysics and Molecular Biology. 99 (1): 1–6. doi: 10.1016/j.pbiomolbio.2008.10.001 . hdl: 11336/25755 . PMID   18977383.
  8. ↑ Tolleter D, Hincha DK, Macherel D (2010). "A mitochondrial late embryogenesis abundant protein stabilizes model membranes in the dry state". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1798 (10): 1926–1933. doi: 10.1016/j.bbamem.2010.06.029 . PMID   20637181.


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