Bioequivalence is a term in pharmacokinetics used to assess the expected in vivo biological equivalence of two proprietary preparations of a drug. If two products are said to be bioequivalent it means that they would be expected to be,for all intents and purposes,the same.
The osmotic-controlled release oral delivery system (OROS) is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it. As the tablet passes through the body,water is absorbed through the semipermeable membrane via osmosis,and the resulting osmotic pressure is used to push the active drug through the laser drilled opening(s) in the tablet and into the gastrointestinal tract. OROS is a trademarked name owned by ALZA Corporation,which pioneered the use of osmotic pumps for oral drug delivery.
Solute carrier family 22 member 8,or organic anion transporter 3 (OAT3),is a protein that in humans is encoded by the SLC22A8 gene.
Drug Development and Industrial Pharmacy is an academic journal that publishes research on aspects of drug development and production,as well as the evaluation of drugs and pharmaceutical products.
Philip Salvatore Portoghese is an American medicinal chemist who has made notable contributions to the design and synthesis of ligands targeting opioid receptors. He is a Distinguished Professor of Medicinal Chemistry at the University of Minnesota,Twin Cities. He also served as the Editor-in-chief of the Journal of Medicinal Chemistry from 1972 to 2012,when the job was taken on by his departmental colleague,Gunda I. Georg,who shares the Editor-in-chief position with Shaomeng Wang at the University of Michigan.
Sarfaraz Khan Niazi he migrated to Karachi,Pakistan in 1962,and to the United States in 1970. He is an expert in biopharmaceutical manufacturing and has worked in academia,industry,and as an entrepreneur. He has written books in pharmaceutical sciences,biotechnology,consumer healthcare,and poetry. He has translated ghazals of the Urdu poet Ghalib.
Vladimir Petrovich Torchilin is a Soviet,Russian and American biochemist,pharmacologist,and an expert in medical nanotechnology. Torchillin is a University Distinguished Professor of Pharmaceutical Sciences at Northeastern University. He also serves as a director at both the Center for Translational Cancer Nanomedicine and at the Center for Pharmaceutical Biotechnology and Nanomedicine at Northeastern University.
Members of the Organo Anion Transporter (OAT) Family are membrane transport proteins or 'transporters' that mediate the transport of mainly organic anions across the cell membrane. Therefore,OATPs are present in the lipid bilayer of the cell membrane,acting as the cell's gatekeepers. OATPs belong to the Solute Carrier Family (SLC) and the major facilitator superfamily.
The Faculty of Pharmacy,Universidade de Lisboa (FFUL) is a Portuguese public institution of higher education dedicated to education,research,knowledge transfer and continuing education in the fields of pharmacy,medicine,and pharmaceutical sciences.
María JoséAlonso Fernandez is a full professor of biopharmaceutics and pharmaceutical technology at the University of Santiago de Compostela. The laboratory she leads is specialized in pharmaceutical nanotechnology and nanomedicine,and her research is oriented to the development of nanostructures for targeted delivery of drugs and vaccines. Her discoveries have led to significant clinical advances in the development of potential new treatments for cancer,ocular diseases,skin diseases,diabetes,obesity and other autoimmune pathologies,as well as new vaccines.
Hartmut Derendorf was a German-American pharmacist and clinical pharmacologist,a distinguished emeritus professor of pharmaceutics at University of Florida. A significant figure in his field,Derendorf published over 20 papers each with over 100 citations.
Mojisola Christianah Adeyeye is a Nigerian pharmacist and professor. She was appointed the Director-General of National Agency for Food and Drug Administration and Control (NAFDAC) on 3 November 2017 by the President of The Federal Republic of Nigeria,Muhammadu Buhari. Before her appointment as NAFDAC boss,she was the founding Chair of Biopharmaceutical Sciences and a Professor of Pharmaceutics,Manufacturing Science and Drug Product Evaluation at the College of Pharmacy,Roosevelt University in Schaumburg,Illinois,where she spent 7 years. She was also a Professor of Pharmaceutics and Manufacturing for 21 years at Duquesne University in Pittsburgh,Pennsylvania,USA. She is Senior Fulbright Scholar and Specialist and 2008 American Association of Pharmaceutical Scientists Fellow. She is also a Fellow of the Nigerian Academy of Science and Nigeria Academy of Pharmacy. Her research interests are in the areas of pre-formulation,early phase development of solid,semisolid and liquid dosage forms,and IND-based and intellectual property-driven late phase drug product development. She is the founder and President of Elim Pediatric Pharmaceuticals Rolling Meadows,Illinois. Through Duquesne University,she was able to develop an anti-retroviral (HIV/AIDS) pediatric fixed-dose combination and received intellectual property on the formulations in the UK and South Africa.
Juliane Nguyen is a professor at UNC Eshelman School of Pharmacy. She received her PharmD and PhD from Philipps-Universität Marburg in Germany,completing her PhD in Thomas Kissel's group. After receiving her degrees,she completed a Post doc with Francis Szoka at University of California,San Francisco. Her research is focused on exosomes and lipid based drug delivery systems. She was awarded a National Science Foundation CAREER award in 2018 for her work as well as over $13M from the NIH and other funding sources. Nguyen’s work has been recognized with numerous awards,including the CMBE Young Innovator Award (2019) from the Biomedical Engineering Society,the AAPS Emerging Leader Award (2019),the NYSTAR Faculty Award (2019),the National Science Foundation CAREER Award (2018),the Pioneering Pharmaceutical Sciences by Emerging Investigators Award (2018),and the University at Buffalo –Exceptional Scholar Young Investigator Award (2017). Nguyen is a Fellow of the Controlled Release Society (2023).
Fakhreddin Jamali is an Iranian-Canadian professor emeritus of pharmacy and pharmaceutical sciences at the University of Alberta. He is the founding president of the Canadian Society for Pharmaceutical Sciences,and the editor-in-chief of Journal of Pharmacy and Pharmaceutical Sciences.
Dr. Jean-Christophe Leroux is a French-Canadian full professor of Drug Formulation and Delivery at the Institute of Pharmaceutical Sciences at the Swiss Federal Institute of Technology ETH Zürich. His research is mainly focused on broadening the field of drug delivery,and the development of biodetoxification systems for the treatment of metabolite disorders. Additionally,he has made important contributions to the field of biomaterials for use in drug delivery.
Kathleen M. Giacomini is a professor of bioengineering and therapeutic sciences at the University of California,San Francisco. Her work focuses on how genetics affects the efficacy of drugs. She is also the co-director UCSF-Stanford Center of Excellence in Regulatory Sciences and Innovation for the department of Bioengineering at the University of California,San Francisco.
Malcolm Rowland FBPhS is Emeritus Professor of Pharmacy,University of Manchester,and Adjunct Professor,University of California San Francisco. His research in pharmacology,has been particularly in physiologically based pharmacokinetics. He has written several textbooks on the subject.
Kishor M. Wasan is a Canadian pharmacologist,pharmacist and professor. He was the dean of the University of Saskatchewan's College of Pharmacy and Nutrition from 2014 to 2019 and associate dean of research and graduate studies at the Faculty of Pharmaceutical Sciences at the University of British Columbia (UBC) from 2011 to 2014. Previously at UBC,he was chair of pharmaceutics and national director of the Canadian Summer Student Research Program after first joining the faculty in 1995. Wasan's research focuses on lipid-based drug delivery and the interaction between lipoprotein and pharmaceuticals. He has published more than 550 peer-reviewed articles and abstracts. He is a founding member and co-director of UBC's Neglected Global Diseases Initiative.
Meir Bialer is an Israeli pharmacologist who is a David H. Eisenberg Emeritus (active) Professor of Pharmacy at the School of Pharmacy,Faculty of Medicine,of The Hebrew University of Jerusalem in Israel.
