Lilly Sanathanan

Last updated

Lalitha (Lilly) Padman Sanathanan is an Indian statistician.

Sanathanan's early research concerned estimation of population size from sampled data, in the context of particle physics. She completed her Ph.D. in 1969, at the University of Chicago; her dissertation, Estimating Population Size in the Particle Scanning Context, was supervised by David Lee Wallace. [1] After several years as an assistant and associate professor at the University of Illinois Chicago, [2] she moved to Argonne National Laboratory in the late 1970s. [3]

By 1991 she had shifted career direction, to drug development. After working as a senior statistician at Abbott Laboratories, associate director of statistics for Ciba-Geigy, and director of research statistics for Smith, Kline & French, she became a director in the Center for Drug Evaluation and Research of the Food and Drug Administration. [4] She was named a Fellow of the American Statistical Association in 1990. [5] In 1991 she returned to private industry, as vice president of biostatistics and clinical data systems at the Institute for Biological Research and Development in Irvine, California. [4] She later founded ClinWorld, a binational (US and Indian) clinical research organisation, which was purchased by Indian health corporation Sami Labs (now the Sami-Sabinsa Group) in 2003. [6]

In 2008 she published a self-help book, Life Vest, in Bangalore. [7] She continues to operate a Florida-based statistics firm, STATLINK, and is a contributor to a cross-cultural podcast, the Global India Podcast. [8]

Related Research Articles

Statistics Study of the collection, analysis, interpretation, and presentation of data

Statistics is the discipline that concerns the collection, organization, analysis, interpretation, and presentation of data. In applying statistics to a scientific, industrial, or social problem, it is conventional to begin with a statistical population or a statistical model to be studied. Populations can be diverse groups of people or objects such as "all people living in a country" or "every atom composing a crystal". Statistics deals with every aspect of data, including the planning of data collection in terms of the design of surveys and experiments.

Low-density lipoprotein One of the five major groups of lipoprotein

Low-density lipoprotein (LDL) is one of the five major groups of lipoprotein that transport all fat molecules around the body in extracellular water. These groups, from least dense to most dense, are chylomicrons, very low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL). LDL delivers fat molecules to cells. LDL is involved in atherosclerosis, a process in which it is oxidized within the walls of arteries.

In statistical hypothesis testing, a result has statistical significance when it is very unlikely to have occurred given the null hypothesis. More precisely, a study's defined significance level, denoted by , is the probability of the study rejecting the null hypothesis, given that the null hypothesis is true; and the p-value of a result, , is the probability of obtaining a result at least as extreme, given that the null hypothesis is true. The result is statistically significant, by the standards of the study, when . The significance level for a study is chosen before data collection, and is typically set to 5% or much lower—depending on the field of study.

In inferential statistics, the null hypothesis is that two possibilities are the same. The null hypothesis is that the observed difference is due to chance alone. Using statistical tests, it is possible to calculate the likelihood that the null hypothesis is true.

The statistical power of a binary hypothesis test is the probability that the test correctly rejects the null hypothesis when a specific alternative hypothesis is true. It is commonly denoted by , and represents the chances of a "true positive" detection conditional on the actual existence of an effect to detect. Statistical power ranges from 0 to 1, and as the power of a test increases, the probability of making a type II error by wrongly failing to reject the null hypothesis decreases.

In probability theory and statistics, the coefficient of variation (CV), also known as relative standard deviation (RSD), is a standardized measure of dispersion of a probability distribution or frequency distribution. It is often expressed as a percentage, and is defined as the ratio of the standard deviation to the mean . The CV or RSD is widely used in analytical chemistry to express the precision and repeatability of an assay. It is also commonly used in fields such as engineering or physics when doing quality assurance studies and ANOVA gauge R&R. In addition, CV is utilized by economists and investors in economic models.

David Spiegelhalter English statistician

Sir David John Spiegelhalter is a British statistician and a Fellow of Churchill College, Cambridge. From 2007 to 2018 he was Winton Professor of the Public Understanding of Risk in the Statistical Laboratory at the University of Cambridge. Spiegelhalter is an ISI highly cited researcher.

In statistics, resampling is any of a variety of methods for doing one of the following:

  1. Estimating the precision of sample statistics by using subsets of available data (jackknifing) or drawing randomly with replacement from a set of data points (bootstrapping)
  2. Permutation tests are exact tests: Exchanging labels on data points when performing significance tests
  3. Validating models by using random subsets

In natural and social science research, a protocol is most commonly a predefined procedural method in the design and implementation of an experiment. Protocols are written whenever it is desirable to standardize a laboratory method to ensure successful replication of results by others in the same laboratory or by other laboratories. Additionally, and by extension, protocols have the advantage of facilitating the assessment of experimental results through peer review. In addition to detailed procedures, equipment, and instruments, protocols will also contain study objectives, reasoning for experimental design, reasoning for chosen sample sizes, safety precautions, and how results were calculated and reported, including statistical analysis and any rules for predefining and documenting excluded data to avoid bias.

Doug Altman English statistician (1948–2018)

Douglas Graham Altman FMedSci was an English statistician best known for his work on improving the reliability and reporting of medical research and for highly cited papers on statistical methodology. He was professor of statistics in medicine at the University of Oxford, founder and Director of Centre for Statistics in Medicine and Cancer Research UK Medical Statistics Group, and co-founder of the international Equator Network for health research reliability.

Medical laboratory Principles of management with special reference to medical science

A medical laboratory or clinical laboratory is a laboratory where tests are carried out on clinical specimens to obtain information about the health of a patient to aid in diagnosis, treatment, and prevention of disease. Clinical Medical laboratories are an example of applied science, as opposed to research laboratories that focus on basic science, such as found in some academic institutions.

Stereology is the three-dimensional interpretation of two-dimensional cross sections of materials or tissues. It provides practical techniques for extracting quantitative information about a three-dimensional material from measurements made on two-dimensional planar sections of the material. Stereology is a method that utilizes random, systematic sampling to provide unbiased and quantitative data. It is an important and efficient tool in many applications of microscopy. Stereology is a developing science with many important innovations being developed mainly in Europe. New innovations such as the proportionator continue to make important improvements in the efficiency of stereological procedures.

Cytel is a multinational statistical software developer and contract research organization, headquartered in Cambridge, Massachusetts, USA. Cytel provides clinical trial design, implementation services, and statistical products primarily for the biotech and pharmaceutical development markets.

Pandurang Vasudeo Sukhatme (1911–1997) was an Indian statistician. He is known for his pioneering work of applying random sampling methods in agricultural statistics and in biometry, in the 1940s. He was also influential in the establishment of the Indian Agricultural Statistics Research Institute. As a part of his work at the Food and Agriculture Organization in Rome, he developed statistical models for assessing the dimensions of hunger and future food supplies for the world. He also developed methods for measuring the size and nature of the protein gap.

Specimen provenance complications (SPCs) result from instances of biopsy specimen transposition, extraneous/foreign cell contamination or misidentification of cells used in clinical or anatomical pathology. If left undetected, SPCs can lead to serious diagnostic mistakes and adverse patient outcomes.

Amarjot Kaur is an Indian statistician who in 2016 became the president of the International Indian Statistical Association. She works for Merck Research Laboratories, as Executive Director of Clinical Biostatistics and Research Decision Sciences. She is also the 2017 treasurer of the American Statistical Association, and in 2013 she chaired the American Statistical Association Community of Applied Statisticians.

Nancy Flournoy is an American statistician. Her research in statistics concerns the design of experiments, and particularly the design of adaptive clinical trials; she is also known for her work on applications of statistics to bone marrow transplantation, and in particular on the graft-versus-tumor effect. She is Curators' Distinguished Professor Emeritus of Statistics at the University of Missouri.

Statsols

Statsols is the producer and distributor of the proprietary nQuery sample size software.

nQuery is a clinical trial design platform used for the design and monitoring of adaptive, group sequential and fixed sample size trials. It is most commonly used by biostatisticians to calculate sample size and statistical power for adaptive clinical trial design. nQuery is a proprietary software developed and distributed by Statsols. The software includes calculations for over 1,000 sample sizes and power scenarios.

References

  1. Lilly Sanathanan at the Mathematics Genealogy Project
  2. Affiliation as listed on her publications "Estimating the Size of a Multinomial Population" (1972, doi:10.1214/aoms/1177692709) and "Estimating the Size of a Truncated Sample" (1977, doi:10.2307/2286238)
  3. DOE Statistical Symposium, Sandia Laboratories (PDF), 1978, p. 332
  4. 1 2 "Lilly P. Sanathanan has joined the Institute...", Los Angeles Times , June 26, 1991, retrieved 2022-08-08
  5. ASA Fellows, American Statistical Association, retrieved 2022-08-08
  6. Urs, Anil (August 5, 2003), "Sami Labs buys CRO ClinWorld", The Economic Times, retrieved 2022-08-08
  7. "Striking the perfect balance", The New Indian Express, December 2, 2008, retrieved 2022-08-08
  8. Global India Podcast , retrieved 2022-08-08