Lim homeobox 9

Last updated
LHX9
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases LHX9 , LIM homeobox 9
External IDs OMIM: 606066 MGI: 1316721 HomoloGene: 7816 GeneCards: LHX9
Gene location (Human)
Ideogram human chromosome 1.svg
Chr. Chromosome 1 (human) [1]
Human chromosome 1 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 1q31.3Start197,911,902 bp [1]
End197,935,478 bp [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001014434
NM_020204
NM_001370213

NM_001025565
NM_001042577
NM_010714

RefSeq (protein)

NP_001014434
NP_064589
NP_001357142

NP_001020736
NP_001036042
NP_034844

Location (UCSC) Chr 1: 197.91 – 197.94 Mb Chr 1: 138.83 – 138.85 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

LIM homeobox 9 is a protein that in humans is encoded by the LHX9 gene. [5]

Contents

Function

This gene encodes a member of the LIM homeobox gene family of developmentally expressed transcription factors. The encoded protein contains a homeodomain and two cysteine-rich zinc-binding LIM domains involved in protein-protein interactions. The protein is highly similar to a mouse protein that causes gonadal agenesis when inactivated, suggesting a role in gonadal development. Alternative splicing results in multiple transcript variants.

Related Research Articles

LHX3

LIM/homeobox protein Lhx3 is a protein that in humans is encoded by the LHX3 gene.

HOXD1

Homeobox protein Hox-D1 is a protein that in humans is encoded by the HOXD1 gene.

HOXC5

Homeobox protein Hox-C5 is a protein that in humans is encoded by the HOXC5 gene.

OTX1

Homeobox protein OTX1 is a protein that in humans is encoded by the OTX1 gene.

LHX6

LIM/homeobox protein Lhx6 is a protein that in humans is encoded by the LHX6 gene.

HOXC11

Homeobox protein Hox-C11 is a protein that in humans is encoded by the HOXC11 gene.

LMX1A

LIM homeobox transcription factor 1, alpha, also known as LMX1A, is a protein which in humans is encoded by the LMX1A gene.

MEIS2

Homeobox protein Meis2 is a protein that in humans is encoded by the MEIS2 gene.

LHX1 Protein-coding gene in the species Homo sapiens

LIM homeobox 1 is a protein that in humans is encoded by the LHX1 gene. This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for control of differentiation and development of neural and lymphoid cells. It is also key in development of renal and urogenital systems and is required for normal organogenesis. A similar protein in mice is an essential regulator of the vertebrate head organizer.

LHX4

LIM/homeobox protein Lhx4 is a protein that in humans is encoded by the LHX4 gene.

LHX2

LIM/homeobox protein Lhx2 is a protein that in humans is encoded by the LHX2 gene.

DBX1

Homeobox protein DBX1, also known as developing brain homeobox protein 1, is a protein that in humans is encoded by the DBX1 gene. The DBX1 gene is a transcription factor gene that is pivotal in interneuron differentiation in the ventral spinal cord.

DBX2

Homeobox protein DBX2, also known as developing brain homeobox protein 2, is a protein that in humans is encoded by the DBX2 gene.

SHOX2

Short-stature homeobox 2, also known as homeobox protein Og12X or paired-related homeobox protein SHOT, is a protein that in humans is encoded by the SHOX2 gene.

HOXC12

Homeobox C12 is a protein that in humans is encoded by the HOXC12 gene.

BARHL2

BarH-like homeobox 2 is a protein in humans that is encoded by the BARHL2 gene.

Sebox homeobox

SEBOX homeobox is a protein that in humans is encoded by the SEBOX gene. Sebox homeobox has a 92% similarity to genes found within rhesus macaque, or the rhesus monkey. It is thought that this is what causes the reddened glutius maximus coloring. If the protein is turned on within a person, it may cause discoloring in the human rear.

ONECUT1

One cut homeobox 1 is a protein that in humans is encoded by the ONECUT1 gene.

Pou class 3 homeobox 3

POU class 3 homeobox 3 is a protein that in humans is encoded by the POU3F3 gene.

PKNOX2

PBX/Knotted 1 Homeobox 2 (PKNOX2) protein belongs to the three amino acid loop extension (TALE) class of homeodomain proteins, and is encoded by PKNOX2 gene in humans. The protein regulates the transcription of other genes and affects anatomical development.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000143355 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019230 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: LIM homeobox 9".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.