This is a list of Howard Bison football players in the NFL draft.
| B | Back | K | Kicker | NT | Nose tackle |
| C | Center | LB | Linebacker | FB | Fullback |
| DB | Defensive back | P | Punter | HB | Halfback |
| DE | Defensive end | QB | Quarterback | WR | Wide receiver |
| DT | Defensive tackle | RB | Running back | G | Guard |
| E | End | T | Offensive tackle | TE | Tight end |
| Year | Round | Pick | Overall | Player | Team | Position |
|---|---|---|---|---|---|---|
| 1940 | 12 | 4 | 104 | George Dougherty | Brooklyn Dodgers | B |
| 1978 | 9 | 7 | 229 | Herman Redden | San Francisco 49ers | DB |
| 1988 | 8 | 24 | 217 | Harvey Reed | Chicago Bears | RB |
| 1989 | 12 | 9 | 316 | Jimmie Johnson | Washington Redskins | TE |
| 12 | 13 | 320 | John Javis | Denver Broncos | WR | |
| 1990 | 6 | 14 | 151 | Sean Vanhorse | Miami Dolphins | DB |
| 1993 | 6 | 16 | 156 | Tim Watson | Green Bay Packers | DB |
| 1994 | 7 | 4 | 198 | Jay Walker | New England Patriots | QB |
| 1995 | 7 | 24 | 232 | Jose White | Minnesota Vikings | LB |
| 2003 | 6 | 20 | 193 | Marques Ogden | Jacksonville Jaguars | T |
| 2005 | 2 | 18 | 50 | Ronald Bartell | St. Louis Rams | DB |
| 2006 | 6 | 38 | 207 | Antoine Bethea | Indianapolis Colts | DB |