This is a list of Mississippi Valley State Delta Devils football players in the NFL draft.
| B | Back | K | Kicker | NT | Nose tackle |
| C | Center | LB | Linebacker | FB | Fullback |
| DB | Defensive back | P | Punter | HB | Halfback |
| DE | Defensive end | QB | Quarterback | WR | Wide receiver |
| DT | Defensive tackle | RB | Running back | G | Guard |
| E | End | T | Offensive tackle | TE | Tight end |
| = Pro Bowler | |
| = Hall of Famer |
| Year | Round | Pick | Overall | Player | Team | Position |
|---|---|---|---|---|---|---|
| 1958 | 15 | 3 | 172 | Stan Hinos | Philadelphia Eagles | T |
| 1961 | 14 | 4 | 186 | Deacon Jones | Los Angeles Rams | DE |
| 1967 | 9 | 2 | 213 | Fred Freeman | New York Giants | T |
| 1968 | 2 | 18 | 45 | Dave McDaniels | Dallas Cowboys | WR |
| 9 | 16 | 235 | Sam Moore | Chicago Bears | T | |
| 1969 | 10 | 3 | 237 | Jeff Stanciel | Atlanta Falcons | RB |
| 1970 | 17 | 1 | 417 | Harry Key | Pittsburgh Steelers | TE |
| 1972 | 17 | 23 | 439 | Ted Washington Sr. | Kansas City Chiefs | LB |
| 1973 | 7 | 24 | 180 | Nate Dorsey | Pittsburgh Steelers | DE |
| 1975 | 13 | 25 | 337 | Robert Gaddis | Pittsburgh Steelers | WR |
| 1976 | 7 | 1 | 183 | Parnell Dickinson | Tampa Bay Buccaneers | QB |
| 10 | 5 | 270 | Ricky Feacher | New England Patriots | WR | |
| 11 | 23 | 314 | Melvin Morgan | Cincinnati Bengals | DB | |
| 12 | 19 | 338 | Herman Harris | San Diego Chargers | DB | |
| 1985 | 1 | 16 | 16 | Jerry Rice | San Francisco 49ers | WR |
| 1986 | 5 | 1 | 111 | Carl Byrum | Buffalo Bills | RB |
| 9 | 23 | 244 | Joe Thomas | Denver Broncos | WR | |
| 1988 | 2 | 16 | 43 | Vincent Brown | New England Patriots | LB |
| 7 | 21 | 186 | Danta Whitaker | New York Giants | TE | |
| 1992 | 2 | 1 | 29 | Ashley Ambrose | Indianapolis Colts | DB |
| 8 | 16 | 212 | Ronald Humphrey | Indianapolis Colts | RB | |