This is a list of North Alabama Lions football players in the NFL draft.
| B | Back | K | Kicker | NT | Nose tackle |
| C | Center | LB | Linebacker | FB | Fullback |
| DB | Defensive back | P | Punter | HB | Halfback |
| DE | Defensive end | QB | Quarterback | WR | Wide receiver |
| DT | Defensive tackle | RB | Running back | G | Guard |
| E | End | T | Offensive tackle | TE | Tight end |
| Year | Round | Overall | Player | Team | Position |
|---|---|---|---|---|---|
| 1954 | 15 | 174 | Harlon Hill | Chicago Bears | E |
| 1956 | 28 | 334 | Billy Hicks | Washington Redskins | B |
| 1958 | 30 | 357 | Billy Lumpkin | New York Giants | E |
| 1980 | 5 | 128 | William Bowens | Oakland Raiders | LB |
| 8 | 219 | Curtis Sirmones | San Diego Chargers | RB | |
| 12 | 327 | Marcene Emmett | Washington Redskins | DB | |
| 1981 | 11 | 284 | Jerry Hill | Washington Redskins | WR |
| 1985 | 9 | 249 | Daryl Smith | Denver Broncos | DB |
| 1986 | 2 | 38 | Lewis Billups | Cincinnati Bengals | DB |
| 7 | 194 | Bruce Jones | Chicago Bears | DB | |
| 11 | 282 | Billy Witt | Buffalo Bills | DE | |
| 1988 | 6 | 163 | Shawn Lee | Tampa Bay Buccaneers | DT |
| 12 | 324 | Wendell Phillips | San Diego Chargers | DB | |
| 1996 | 5 | 163 | Israel Raybon | Pittsburgh Steelers | DE |
| 7 | 212 | Jarius Hayes | Arizona Cardinals | TE | |
| 7 | 233 | Marcus Keyes | Chicago Bears | DT | |
| 1999 | 4 | 122 | Bobby Collins | Buffalo Bills | TE |
| 6 | 178 | Tyrone Bell | San Diego Chargers | DB | |
| 2012 | 2 | 39 | Janoris Jenkins | St. Louis Rams | DB |