State Road 50 runs across the center of the U.S. state of Florida through Orlando, with its termini at SR 55 at Weeki Wachee and SR 5 in Titusville.
State Road 421 is a major thoroughfare that runs east–west through Port Orange, Florida from Interstate 95 (I-95) east to U.S. Route 1 (US 1) where it turns into SR A1A. It is partially six lanes and 4 lanes, and is known locally as Taylor Road and Dunlawton Avenue.
State Road 100 is a 153-mile-long (246 km) east–west highway serving northeast Florida. Its western terminus is at the Georgia-Florida border four miles (6.4 km) north of Avoca, Florida ; its eastern terminus is an intersection with Shore Scenic Highway in Flagler Beach. The portion west of Lake City is only signed as portions of US 41 and US 129, both of which run north–south.
State Road 200 is a major diagonal road in central and northeast Florida. Its southern terminus is at US 41 in Hernando. Its eastern terminus is at SR A1A in Fernandina Beach, at the corner of Atlantic Avenue and Fletcher Avenue.
State Road 65 is a north–south route in the eastern panhandle, running from a junction with US 98/319 near Eastpoint northwards through the Apalachicola National Forest to SR 12 west of Quincy, near US 90.
State Road 40 is a 91.8-mile-long (147.7 km) east–west highway across northern and east-central Florida, running from U.S. Highway 41 (US 41) in Rainbow Lakes Estates eastward through Ocala over the Ocklawaha River and through the heart of the Ocala National Forest to SR A1A in Ormond Beach. Names of the road include Silver Springs Boulevard in Ocala, Fort Brooks Road from Silver Springs through Astor, Butler Road in Astor, and Granada Boulevard in Ormond Beach. Former sections in Ormond Beach are named "Old Tomoka Road" and "Old Tomoka Avenue."
State Road 44 is an east–west state highway in the U.S. state of Florida. It runs from Crystal River on the Gulf of Mexico east to New Smyrna Beach on the Atlantic Ocean, passing through Inverness, Wildwood, Leesburg and DeLand.
State Road 51 is a north–south state highway in north Florida. Its northern terminus is along the overlap of US 41 and US 129. It runs southwards as the "secret" designation of US 129 to Live Oak, where it splits off and runs independently south to Steinhatchee. The Hal W. Adams Bridge carries it across the Suwannee River three miles (5 km) north of Mayo.
State Road 806 (SR 806), locally known as Atlantic Avenue, is the primary east–west highway of Delray Beach in Palm Beach County, Florida. Not to be confused with parallel Atlantic Boulevard (SR 814) 15 miles (24.14 km) to the south, Atlantic Avenue extends from U.S. Route 441 (US 441) and SR 7 eastward to SR A1A just north of Highland Beach. East of Military Trail, SR 806 is in the city of Delray Beach; to the west of Military Trail, the road stretches through unincorporated Palm Beach County in the CDPs of High Point, Kings Point, and the Villages of Oriole.
U.S. Highway 41 (US 41) in the state of Florida is a north–south United States Highway. It runs 479 miles (771 km) from Miami in South Florida northwest to the Georgia state line north of the Lake City area. Within the state, US 41 is paralleled by Interstate 75 (I-75) all the way from Miami to Georgia, and I-75 has largely supplanted US 41 as a major highway.
U.S. Route 90 (US 90) in the state of Florida is the northernmost east–west United States Numbered Highway in the state. US 90 not only passes through the county seats of all the 16 counties it runs through on its course in Florida and is also the road upon which many of the county courthouses are located, but it was the first paved road in Florida. It is never more than six miles (9.7 km) from Interstate 10 (I-10) throughout the state. It runs as a two-lane highway through most of the sparsely populated inland areas of the Florida Panhandle, widening to four lanes through and near several towns. The speed limit is 55 mph (89 km/h) for all rural points west of Monticello, and it is 60 mph (97 km/h) on all rural points from where it enters Madison County as far as Glen St. Mary.
U.S. Route 98 is a major east-west thoroughfare through the U.S. state of Florida. Spanning 670.959 miles (1,079.804 km), it connects Pensacola and the Alabama/Florida state line to the west with Palm Beach and the Atlantic coast in the east. It is the longest US road in Florida, as well as the longest US road in any state east of the Mississippi River.
U.S. Route 129 (US 129) in Florida is a north–south United States Highway. It runs 88 miles (142 km) from Chiefland north to the Georgia State Line in Levy, Gilchrist, Suwannee, and Hamilton Counties.
State Road 249 is the state designation for U.S. Route 129 between US 27(SR 20) in Branford and US 90(SR 10) in Live Oak. It also includes a bi-county extension in Suwannee County, Florida from Live Oak across the Suwannee River to Jasper in Hamilton County.
State Road 83 is the state designation for U.S. Route 331 between US 98(SR 30) in Santa Rosa Beach and US 90(SR 10) in DeFuniak Springs. It also includes an independent route from DeFuniak Springs to the Florida-Alabama State Line. The entire route is in Walton County.
U.S. Route 129 (US 129) is a 375-mile-long (604 km) U.S. Highway in the U.S. state of Georgia. It travels south-to-north from the Florida state line, south of Statenville, to the North Carolina state line, northwest of Blairsville.
State Road 73, the Wayne Mixson State Highway, is a state highway in northwest Florida that runs through Calhoun and Jackson Counties, although it runs through more of the former county than the latter one. The road is always on the west side of the Chipola River, and is almost entirely two-lanes wide, except with its concurrency with US 90 in Marianna where it is four-lanes wide. It was named in honor of former Florida governor Wayne Mixson.
State Road 276 is a state road in the panhandle of Florida. It runs west to east from former State Road 167 into U.S. Route 90 in and around Marianna entirely within Jackson County, although a bi-county extension exists between State Road 277 southwest of Chipley in Washington County that runs south then east into CR 167 which is signed as County Road 276 (CR 276). Most of the road is a two-lane undivided highway, with exceptions in the vicinity of Interstate 10, and if you count the bi-county portion, the overlapped segment with U.S. 231 where it changes from a four-lane undivided highway to a four-lane divided highway between Alford and Steele City.
