This is a list of the Irish Recorded Music Association's Irish Singles Chart Top 50 number-ones of 2000.
| Issue date | Song | Artist |
|---|---|---|
| 1 January | "I Have a Dream"/"Seasons in the Sun" | Westlife |
| 8 January | ||
| 15 January | ||
| 22 January | "Born to Make You Happy" | Britney Spears |
| 29 January | ||
| 5 February | "Silence" | Delerium |
| 12 February | "Go Let It Out" | Oasis |
| 19 February | "Rise" | Gabrielle |
| 26 February | "Pure Shores" | All Saints |
| 4 March | "Maniac 2000" | Mark McCabe |
| 11 March | ||
| 18 March | ||
| 25 March | ||
| 1 April | ||
| 8 April | ||
| 15 April | ||
| 22 April | ||
| 29 April | ||
| 6 May | ||
| 13 May | "The Bad Touch" | Bloodhound Gang |
| 20 May | ||
| 27 May | ||
| 3 June | ||
| 10 June | "Gotta Tell You" | Samantha Mumba |
| 17 June | ||
| 24 June | ||
| 1 July | ||
| 8 July | ||
| 15 July | "Life Is a Rollercoaster" | Ronan Keating |
| 22 July | "The Real Slim Shady" | Eminem |
| 29 July | ||
| 5 August | "Rock DJ" | Robbie Williams |
| 12 August | ||
| 19 August | ||
| 26 August | ||
| 2 September | "Groovejet (If This Ain't Love)" | Spiller feat. Sophie Ellis-Bextor |
| 9 September | ||
| 16 September | "Lady (Hear Me Tonight)" | Modjo |
| 23 September | "Against All Odds (Take a Look at Me Now)" | Mariah Carey featuring Westlife |
| 30 September | ||
| 7 October | ||
| 14 October | "Beautiful Day" | U2 |
| 21 October | ||
| 28 October | ||
| 4 November | "My Love" | Westlife |
| 11 November | ||
| 18 November | ||
| 25 November | "Can't Fight the Moonlight" | LeAnn Rimes |
| 2 December | ||
| 9 December | "Stan" | Eminem |
| 16 December | ||
| 23 December | ||
| 30 December |