The following is a list of the IRMA's number-one singles of 2001.
| Issue Date | Song | Artist |
|---|---|---|
| 5 January | "Stan" | Eminem featuring Dido |
| 13 January | ||
| 20 January | "Touch Me" | Rui da Silva featuring Cassandra |
| 27 January | ||
| 3 February | "Stuck in a Moment You Can't Get Out Of" | U2 |
| 10 February | "Rollin' (Air Raid Vehicle)" | Limp Bizkit |
| 17 February | "Whole Again" | Atomic Kitten |
| 24 February | "Always Come Back to Your Love" | Samantha Mumba |
| 3 March | "It Wasn't Me" | Shaggy featuring Rikrok |
| 10 March | "Uptown Girl" | Westlife |
| 17 March | ||
| 24 March | ||
| 31 March | ||
| 7 April | ||
| 14 April | ||
| 21 April | "Survivor" | Destiny's Child |
| 28 April | "Don't Stop Movin'" | S Club 7 |
| 5 May | "It's Raining Men" | Geri Halliwell |
| 12 May | ||
| 19 May | ||
| 26 May | ||
| 2 June | "Angel" | Shaggy featuring Rayvon |
| 9 June | ||
| 16 June | ||
| 23 June | ||
| 30 June | "Lady Marmalade" | Christina Aguilera, Lil' Kim, Mýa & Pink |
| 7 July | ||
| 14 July | ||
| 21 July | "Elevation" | U2 |
| 28 July | "Hey Baby (Uhh, Ahh)" | DJ Ötzi |
| 4 August | ||
| 11 August | ||
| 18 August | ||
| 25 August | ||
| 1 September | ||
| 8 September | "Let Me Blow Ya Mind" | Eve featuring Gwen Stefani |
| 15 September | "Follow Me" | Uncle Kracker |
| 22 September | "Can't Get You Out of My Head" | Kylie Minogue |
| 29 September | ||
| 6 October | ||
| 13 October | ||
| 20 October | "Because I Got High" | Afroman |
| 27 October | ||
| 3 November | ||
| 10 November | "Queen of My Heart" | Westlife |
| 17 November | ||
| 24 November | "Sweet Caroline" | Dustin |
| 1 December | ||
| 8 December | "What If" | Kate Winslet |
| 15 December | ||
| 22 December | ||
| 29 December |