Joseph Harry Fowler Connick Jr. is an American singer, pianist, composer, actor, and former television host. As of 2019, he has sold over 30 million records worldwide. Connick is ranked among the top 60 best-selling male artists in the United States by the Recording Industry Association of America, with 16 million in certified sales. He has had seven top 20 U.S. albums, and ten number-one U.S. jazz albums, earning more number-one albums than any other artist in U.S. jazz chart history as of 2009.
Bernadette Peters is an American actress and singer. Over a career spanning more than six decades, she has starred in musical theatre, television and film, performed in solo concerts and released recordings. She is a critically acclaimed Broadway performer, having received seven nominations for Tony Awards, winning two, and nine Drama Desk Award nominations, winning three. Four of the Broadway cast albums on which she has starred have won Grammy Awards.
Renée Kathleen Zellweger is an American actress. The recipient of various accolades, including two Academy Awards, two British Academy Film Awards, and four Golden Globe Awards, she was one of the world's highest-paid actresses by 2007.
Genentech, Inc. is an American biotechnology corporation headquartered in South San Francisco, California. It became an independent subsidiary of Roche in 2009. Genentech Research and Early Development operates as an independent center within Roche. Historically, the company is regarded as the world's first biotechnology company.
Trastuzumab, sold under the brand name Herceptin among others, is a monoclonal antibody used to treat breast cancer and stomach cancer. It is specifically used for cancer that is HER2 receptor positive. It may be used by itself or together with other chemotherapy medication. Trastuzumab is given by slow injection into a vein and injection just under the skin.
Trudie Styler is an English actress, director, and film producer.
Breast Men is a 1997 American, semibiographical, dark comedy drama film; it was written by John Stockwell and directed by Lawrence O'Neil for HBO.
Lapatinib (INN), used in the form of lapatinib ditosylate (USAN) is an orally active drug for breast cancer and other solid tumours. It is a dual tyrosine kinase inhibitor which interrupts the HER2/neu and epidermal growth factor receptor (EGFR) pathways. It is used in combination therapy for HER2-positive breast cancer. It is used for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress HER2 (ErbB2).
Tammy Blanchard is an American actress. She rose to prominence for her role as teenage Judy Garland in the critically acclaimed television film Life with Judy Garland: Me and My Shadows (2001), for which she received a Golden Globe Award nomination and a Primetime Emmy Award. Her other notable film roles were in The Good Shepherd (2006), Sybil (2007), Into the Woods (2014) and The Invitation (2015).
The 60th Annual Tony Awards were held at Radio City Music Hall on June 11, 2006. The award ceremony was broadcast live on the CBS television network in the United States. The 2006 Tony Awards did not feature a host, but instead over 60 stars presented awards at the ceremony.
Josep Baselga i Torres, known in Spanish as José Baselga, was a Spanish medical oncologist and researcher focused on the development of novel molecular targeted agents, with a special emphasis in breast cancer. Through his career he was associated with the Memorial Sloan Kettering Cancer Center, Vall d'Hebron Institute of Oncology, and the Massachusetts General Hospital in their hematology and oncology divisions. He led the development of the breast cancer treatment Herceptin, a monoclonal antibody, that targets the HER2 protein, which is impacted in aggressive breast cancers.
Daniel Frederick Ireland was an American-Canadian film producer and director. He was the co-founder of the Seattle International Film Festival. Ireland began executive-producing films for Vestron Pictures in the 1980s, his first being John Huston's final feature, The Dead (1987). He also executive-produced multiple films by director Ken Russell, such as Salome's Last Dance (1987), The Lair of the White Worm (1988), The Rainbow (1989), and Whore (1991).
Lilly Tartikoff Karatz is an American activist, socialite, restaurateur and fundraiser for breast cancer.
What a Night! A Christmas Album, by American singer, pianist and bandleader Harry Connick Jr., was released on November 4, 2008., being his third Christmas album, since 1993's When My Heart Finds Christmas and 2003's Harry for the Holidays. The album consists of new recordings of Christmas classics, and new songs written by Connick.
Robert Bazell is adjunct professor of Molecular Cellular and Developmental Biology at Yale University. He is the former chief science and health correspondent for NBC News.
Dennis Joseph Slamon, is an American oncologist and chief of the division of Hematology-Oncology at UCLA. He is best known for his work identifying the HER2/neu oncogene that is amplified in 25–33% of breast cancer patients and the resulting treatment trastuzumab.
1 a Minute is a 2010 American docudrama film written and directed by Indian American actress Namrata Singh Gujral. It is based on her own life and the lives of other women who suffered from cancer.
Jonathan S. Berek, MD MMS is the Laurie Kraus Lacob Professor at the Stanford University School of Medicine, Director of the Stanford Women's Cancer Center, and Senior Advisor, Stanford Cancer Institute. He is a recent past Fellow in the Stanford Distinguished Careers Institute.
Trastuzumab emtansine, sold under the brand name Kadcyla, is an antibody-drug conjugate consisting of the humanized monoclonal antibody trastuzumab (Herceptin) covalently linked to the cytotoxic agent DM1. Trastuzumab alone stops growth of cancer cells by binding to the HER2 receptor, whereas trastuzumab emtansine undergoes receptor-mediated internalization into cells, is catabolized in lysosomes where DM1-containing catabolites are released and subsequently bind tubulin to cause mitotic arrest and cell death. Trastuzumab binding to HER2 prevents homodimerization or heterodimerization (HER2/HER3) of the receptor, ultimately inhibiting the activation of MAPK and PI3K/AKT cellular signalling pathways. Because the monoclonal antibody targets HER2, and HER2 is only over-expressed in cancer cells, the conjugate delivers the cytotoxic agent DM1 specifically to tumor cells. The conjugate is abbreviated T-DM1.
Galena Biopharma, Inc. was a publicly traded pharmaceutical company based in San Ramon, California. The company was founded in Worcester, Massachusetts. In 2011, it moved to Oregon, and in 2015 moved to San Ramon, California. Mark Schwartz was the company's president and chief executive officer. As of December 29, 2017, the company was acquired by Sellas Life Sciences Group Ltd. through a reverse merger transaction. Galena Biopharma was renamed to Sellas Life Sciences Group, Inc..
