MAGEA9

MAGEA9
Identifiers
Aliases	MAGEA9 , CT1.9, MAGE9, MAGE family member A9
External IDs	OMIM: 300342 HomoloGene: 129593 GeneCards: MAGEA9
Gene location (Human) Chr. X chromosome (human) [1] Band Xq28 Start 149,781,930 bp [1] End 149,787,737 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in human musculoskeletal system muscle of leg triceps surae gastrocnemius muscle abdominal segment of trunk arthropod abdomen dorsolateral prefrontal cortex connective tissue adipose tissue tibial nerve n/a More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding molecular function Cellular component cellular component Biological process biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4108 n/a Ensembl ENSG00000123584 n/a UniProt P43362 n/a RefSeq (mRNA) NM_005365 n/a RefSeq (protein) NP_001074259 n/a Location (UCSC) Chr X: 149.78 – 149.79 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Melanoma-associated antigen 9 is a protein that in humans is encoded by the MAGEA9 gene. ^{[3] [4]}

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. ^[4]

References

1. GRCh38: Ensembl release 89: ENSG00000123584 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Rogner UC, Wilke K, Steck E, Korn B, Poustka A (Mar 1996). "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28". Genomics. 29 (3): 725–31. doi:10.1006/geno.1995.9945. PMID   8575766.
4. "Entrez Gene: MAGEA9 melanoma antigen family A, 9".

Further reading

• Oehlrich N, Devitt G, Linnebacher M, et al. (2005). "Generation of RAGE-1 and MAGE-9 peptide-specific cytotoxic T-lymphocyte lines for transfer in patients with renal cell carcinoma". Int. J. Cancer. 117 (2): 256–64. doi: 10.1002/ijc.21200 . PMID   15900605.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Lee JH, Sung BW, Youn HJ, Park JH (2001). "Identification, expression, and nuclear location of murine Mage-b2 protein, a tumor-associated antigen". Mol. Cells. 10 (6): 647–53. doi:10.1007/s10059-000-0647-7. PMID   11211869. S2CID   25338053.
• Serrano A, Lethé B, Delroisse JM, et al. (1999). "Quantitative evaluation of the expression of MAGE genes in tumors by limiting dilution of cDNA libraries". Int. J. Cancer. 83 (5): 664–9. doi: 10.1002/(SICI)1097-0215(19991126)83:5<664::AID-IJC16>3.0.CO;2-V . PMID   10521804.
• Timms KM, Bondeson ML, Ansari-Lari MA, et al. (1997). "Molecular and phenotypic variation in patients with severe Hunter syndrome". Hum. Mol. Genet. 6 (3): 479–86. doi: 10.1093/hmg/6.3.479 . PMID   9147653.
• De Plaen E, Arden K, Traversari C, et al. (1994). "Structure, chromosomal localization, and expression of 12 genes of the MAGE family". Immunogenetics. 40 (5): 360–9. doi:10.1007/BF01246677. PMID   7927540. S2CID   11331427.