MAGEC2

MAGEC2
Identifiers
Aliases	MAGEC2 , CT10, HCA587, MAGEE1, MAGE family member C2
External IDs	OMIM: 300468 HomoloGene: 130677 GeneCards: MAGEC2
Gene location (Human)
Chr.	X chromosome (human)
End	142,205,290 bp
RNA expression pattern
	Top expressed in
	renal cortex; ; human musculoskeletal system; ; muscular system; ; muscle; ; muscle; ; blood; ; lower leg; ; gastrocnemius muscle; ; ventricle; ; left ventricle;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; ubiquitin protein ligase binding ;
Cellular component	nucleus ; cytoplasm ; nucleolus ; cytosol ;
Biological process	positive regulation of ubiquitin-protein transferase activity ;
	Sources:Amigo / QuickGO
Orthologs
	51438
	n/a
	ENSG00000046774
	n/a
	Q9UBF1
	n/a
	NM_016249
	n/a
	NP_057333
	n/a
	Wikidata
View/Edit Human

Last updated April 27, 2024

Melanoma-associated antigen C2 is a protein that in humans is encoded by the MAGEC2 gene.^[3]^[4]

This gene is related to members of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the MAGEC genes are clustered on chromosome Xq26-q27.^[4]

Related Research Articles

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Cancer/testis (CT) antigens are a group of proteins united by their importance in development and in cancer immunotherapy. In general, expression of these proteins is restricted to male germ cells in the adult animal. However, in cancer these developmental antigens are often re-expressed and can serve as a locus of immune activation. Thus, they are often classified as tumor antigens. The expression of CT antigens in various malignancies is heterogeneous and often correlates with tumor progression. CT antigens have been described in melanoma, liver cancer, lung cancer, bladder cancer, and pediatric tumors such as neuroblastoma. Gametogenesis offers an important role for many of these antigens in the differentiation, migration, and cell division of primordial germ cells, spermatogonia spermatocytes and spermatids. Because of their tumor-restricted expression and strong in vivo immunogenicity, CT antigens are identified as ideal targets for tumor specific immunotherapeutic approaches and prompted the development of several clinical trials of CT antigens-based vaccine therapy. CT antigens have been found to have at least 70 families so far, including about 140 members, most of which are expressed during spermatogenesis. Their expression are mainly regulated by epigenetic events, specifically, DNA methylation.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000046774 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gure AO, Stockert E, Arden KC, Boyer AD, Viars CS, Scanlan MJ, Old LJ, Chen YT (Mar 2000). "CT10: a new cancer-testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational-difference analysis". Int J Cancer. 85 (5): 726–32. doi:10.1002/(SICI)1097-0215(20000301)85:5<726::AID-IJC21>3.0.CO;2-F. PMID 10699956. S2CID 42873107.
1 2 "Entrez Gene: MAGEC2 melanoma antigen family C, 2".

Lucas S, De Plaen E, Boon T (2000). "MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression". Int. J. Cancer. 87 (1): 55–60. doi:10.1002/1097-0215(20000701)87:1<55::AID-IJC8>3.0.CO;2-J. PMID 10861452. S2CID 32983052.
Sasaki M, Nakahira K, Kawano Y, et al. (2001). "MAGE-E1, a new member of the melanoma-associated antigen gene family and its expression in human glioma". Cancer Res. 61 (12): 4809–14. PMID 11406556.
Kawano Y, Sasaki M, Nakahira K, et al. (2001). "Structural characterization and chromosomal localization of the MAGE-E1 gene". Gene. 277 (1–2): 129–37. doi:10.1016/S0378-1119(01)00698-9. hdl: 2433/149322 . PMID 11602350. S2CID 19474178.
Wang Y, Han KJ, Pang XW, et al. (2002). "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies". J. Immunol. 169 (2): 1102–9. doi: 10.4049/jimmunol.169.2.1102 . PMID 12097419.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Li B, Qian XP, Pang XW, et al. (2003). "HCA587 antigen expression in normal tissues and cancers: correlation with tumor differentiation in hepatocellular carcinoma". Lab. Invest. 83 (8): 1185–92. doi:10.1097/01.LAB.0000080605.73839.96. PMID 12920247. S2CID 2149577.
Ma W, Germeau C, Vigneron N, et al. (2004). "Two new tumor-specific antigenic peptides encoded by gene MAGE-C2 and presented to cytolytic T lymphocytes by HLA-A2". Int. J. Cancer. 109 (5): 698–702. doi: 10.1002/ijc.20038 . PMID 14999777. S2CID 39772412.
Wang Y, Liang Z, Yuan YH, et al. (2004). "[Expression of multiple cancer-testis antigen genes in non-small cell lung cancer treated by chemotherapy prior surgery]". Zhonghua Yi Xue Za Zhi. 84 (6): 464–8. PMID 15061963.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286 . PMID 15772651.
Godelaine D, Carrasco J, Brasseur F, et al. (2007). "A new tumor-specific antigen encoded by MAGE-C2 and presented to cytolytic T lymphocytes by HLA-B44". Cancer Immunol. Immunother. 56 (6): 753–9. doi:10.1007/s00262-006-0244-5. PMC 11030963 . PMID 17096150. S2CID 13138922.
Yang B, Wu J, Maddodi N, et al. (2007). "Epigenetic control of MAGE gene expression by the KIT tyrosine kinase". J. Invest. Dermatol. 127 (9): 2123–8. doi: 10.1038/sj.jid.5700836 . PMID 17495964.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000046774 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10699956-3] Gure AO, Stockert E, Arden KC, Boyer AD, Viars CS, Scanlan MJ, Old LJ, Chen YT (Mar 2000). "CT10: a new cancer-testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational-difference analysis". Int J Cancer. 85 (5): 726–32. doi:10.1002/(SICI)1097-0215(20000301)85:5<726::AID-IJC21>3.0.CO;2-F. PMID 10699956. S2CID 42873107.

[entrez-4] 1 2 "Entrez Gene: MAGEC2 melanoma antigen family C, 2".

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MAGEC2

Related Research Articles

References

Further reading