MAGEC2

MAGEC2
Identifiers
Aliases	MAGEC2 , CT10, HCA587, MAGEE1, MAGE family member C2
External IDs	OMIM: 300468; HomoloGene: 130677; GeneCards: MAGEC2; OMA:MAGEC2 - orthologs
Gene location (Human) Chr. X chromosome (human) [1] Band Xq27.2 Start 142,202,342 bp [1] End 142,205,290 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad right testis left testis renal cortex human musculoskeletal system muscular system muscle muscle skeletal muscle n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin protein ligase binding Cellular component nucleus cytoplasm nucleolus cytosol Biological process positive regulation of ubiquitin-protein transferase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51438 n/a Ensembl ENSG00000046774 n/a UniProt Q9UBF1 n/a RefSeq (mRNA) NM_016249 n/a RefSeq (protein) NP_057333 n/a Location (UCSC) Chr X: 142.2 – 142.21 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Melanoma-associated antigen C2 is a protein that in humans is encoded by the MAGEC2 gene. ^{[3] [4]}

This gene is related to members of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the MAGEC genes are clustered on chromosome Xq26-q27. ^[4]

References

1. GRCh38: Ensembl release 89: ENSG00000046774 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Gure AO, Stockert E, Arden KC, Boyer AD, Viars CS, Scanlan MJ, Old LJ, Chen YT (Mar 2000). "CT10: a new cancer-testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational-difference analysis". Int J Cancer. 85 (5): 726–32. doi:10.1002/(SICI)1097-0215(20000301)85:5<726::AID-IJC21>3.0.CO;2-F. PMID   10699956. S2CID   42873107.
4. "Entrez Gene: MAGEC2 melanoma antigen family C, 2".

Further reading

• Lucas S, De Plaen E, Boon T (2000). "MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression". Int. J. Cancer. 87 (1): 55–60. doi:10.1002/1097-0215(20000701)87:1<55::AID-IJC8>3.0.CO;2-J. PMID   10861452. S2CID   32983052.
• Sasaki M, Nakahira K, Kawano Y, et al. (2001). "MAGE-E1, a new member of the melanoma-associated antigen gene family and its expression in human glioma". Cancer Res. 61 (12): 4809–14. PMID   11406556.
• Kawano Y, Sasaki M, Nakahira K, et al. (2001). "Structural characterization and chromosomal localization of the MAGE-E1 gene". Gene. 277 (1–2): 129–37. doi:10.1016/S0378-1119(01)00698-9. hdl: 2433/149322 . PMID   11602350. S2CID   19474178.
• Wang Y, Han KJ, Pang XW, et al. (2002). "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies". J. Immunol. 169 (2): 1102–9. doi: 10.4049/jimmunol.169.2.1102 . PMID   12097419.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Li B, Qian XP, Pang XW, et al. (2003). "HCA587 antigen expression in normal tissues and cancers: correlation with tumor differentiation in hepatocellular carcinoma". Lab. Invest. 83 (8): 1185–92. doi: 10.1097/01.LAB.0000080605.73839.96 . PMID   12920247. S2CID   2149577.
• Ma W, Germeau C, Vigneron N, et al. (2004). "Two new tumor-specific antigenic peptides encoded by gene MAGE-C2 and presented to cytolytic T lymphocytes by HLA-A2". Int. J. Cancer. 109 (5): 698–702. doi: 10.1002/ijc.20038 . PMID   14999777. S2CID   39772412.
• Wang Y, Liang Z, Yuan YH, et al. (2004). "[Expression of multiple cancer-testis antigen genes in non-small cell lung cancer treated by chemotherapy prior surgery]". Zhonghua Yi Xue Za Zhi. 84 (6): 464–8. PMID   15061963.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC   2665286 . PMID   15772651.
• Godelaine D, Carrasco J, Brasseur F, et al. (2007). "A new tumor-specific antigen encoded by MAGE-C2 and presented to cytolytic T lymphocytes by HLA-B44". Cancer Immunol. Immunother. 56 (6): 753–9. doi:10.1007/s00262-006-0244-5. PMC   11030963 . PMID   17096150. S2CID   13138922.
• Yang B, Wu J, Maddodi N, et al. (2007). "Epigenetic control of MAGE gene expression by the KIT tyrosine kinase". J. Invest. Dermatol. 127 (9): 2123–8. doi: 10.1038/sj.jid.5700836 . PMID   17495964.