MAN2A1

MAN2A1
Identifiers
Aliases	MAN2A1 , AMan II, GOLIM7, MANA2, MANII, mannosidase alpha class 2A member 1
External IDs	OMIM: 154582 MGI: 104669 HomoloGene: 1777 GeneCards: MAN2A1
Gene location (Human)
Chr.	Chromosome 5 (human)
End	109,869,625 bp
Gene ontology
Molecular function	• mannosidase activity ; • hydrolase activity, hydrolyzing N-glycosyl compounds ; • hydrolase activity, acting on glycosyl bonds ; • metal ion binding ; • catalytic activity ; • mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity ; • hydrolase activity ; • carbohydrate binding ; • alpha-mannosidase activity ;
Cellular component	• integral component of membrane ; • Golgi apparatus ; • membrane ; • Golgi membrane ; • cis-Golgi network ; • extracellular exosome ; • extracellular space ; • Golgi medial cisterna ;
Biological process	• N-glycan processing ; • mitochondrion organization ; • vacuole organization ; • in utero embryonic development ; • protein deglycosylation ; • respiratory gaseous exchange by respiratory system ; • positive regulation of neurogenesis ; • retina morphogenesis in camera-type eye ; • protein glycosylation ; • liver development ; • lung alveolus development ; • metabolism ; • mannose metabolic process ; • carbohydrate metabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	4124
	17158
	ENSG00000112893
	ENSMUSG00000024085
	Q16706
	P27046
	NM_002372
	NM_008549
	NP_002363
	NP_032575
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 09, 2021

Alpha-mannosidase 2 is an enzyme that in humans is encoded by the MAN2A1 gene.^[4]^[5]^[6]

Function

This gene encodes a protein which is a member of family 38 of the glycosyl hydrolases. The protein is located in the Golgi apparatus and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-linked glycosylation) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus.^[6]

Related Research Articles

Envelope glycoprotein GP120 Glycoprotein exposed on the surface of the HIV virus

Envelope glycoprotein GP120 is a glycoprotein exposed on the surface of the HIV envelope. It was discovered by Professors Tun-Hou Lee and Myron "Max" Essex of the Harvard School of Public Health in 1988. The 120 in its name comes from its molecular weight of 120 kDa. Gp120 is essential for virus entry into cells as it plays a vital role in attachment to specific cell surface receptors. These receptors are DC-SIGN, Heparan Sulfate Proteoglycan and a specific interaction with the CD4 receptor, particularly on helper T-cells. Binding to CD4 induces the start of a cascade of conformational changes in gp120 and gp41 that lead to the fusion of the viral membrane with the host cell membrane. Binding to CD4 is mainly electrostatic although there are van der Waals interactions and hydrogen bonds.

Acid alpha-glucosidase, also called α-1,4-glucosidase and acid maltase, is an enzyme that helps to break down glycogen in the lysosome. It is functionally similar to glycogen debranching enzyme, but is on a different chromosome, processed differently by the cell and is located in the lysosome rather than the cytosol. In humans, it is encoded by the GAA gene. Errors in this gene cause glycogen storage disease type II.

Alpha-(1,6)-fucosyltransferase is an enzyme that in humans is encoded by the FUT8 gene.

Neutral alpha-glucosidase C is an enzyme that in humans is encoded by the GANC gene.

Neutral alpha-glucosidase AB is an enzyme that in humans is encoded by the GANAB gene.

Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase is an enzyme that in humans is encoded by the MAN1B1 gene.

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase is an enzyme that in humans is encoded by the ST3GAL4 gene.

ST3 beta-galactoside alpha-2,3-sialyltransferase 3, also known as ST3GAL3, is a protein which in humans is encoded by the ST3GAL3 gene.

Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT2 gene.

Beta-1,4-galactosyltransferase 2 is an enzyme that in humans is encoded by the B4GALT2 gene.

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B is an enzyme that in humans is encoded by the MGAT4B gene.

Glycoprotein endo-alpha-1,2-mannosidase is an enzyme that in humans is encoded by the MANEA gene.

Epididymis-specific alpha-mannosidase is an enzyme that in humans is encoded by the MAN2B2 gene.

Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA is an enzyme that in humans is encoded by the MAN1A1 gene.

Mannosyl-oligosaccharide glucosidase is an enzyme that in humans is encoded by the MOGS gene.

Beta-mannosidase is an enzyme with systematic name beta-D-mannoside mannohydrolase, which is in humans encoded by the MANBA gene. This enzyme catalyses the following chemical reaction

Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B is an enzyme that in humans is encoded by the MGAT5B gene.

GBA2 is the gene that encodes the enzyme non-lysosomal glucosylceramidase in humans. It has glucosylceramidase activity.

Beta-1,4-galactosyltransferase 3 is an enzyme that in humans is encoded by the B4GALT3 gene.

Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB is an enzyme that in humans is encoded by the MAN1A2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000112893 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Moremen KW, Robbins PW (Dec 1991). "Isolation, characterization, and expression of cDNAs encoding murine alpha-mannosidase II, a Golgi enzyme that controls conversion of high mannose to complex N-glycans". The Journal of Cell Biology. 115 (6): 1521–34. doi:10.1083/jcb.115.6.1521. PMC 2289207 . PMID 1757461.
↑ Oka T, Ungar D, Hughson FM, Krieger M (May 2004). "The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins". Molecular Biology of the Cell. 15 (5): 2423–35. doi:10.1091/mbc.E03-09-0699. PMC 404034 . PMID 15004235.
1 2 "Entrez Gene: MAN2A1 mannosidase, alpha, class 2A, member 1".

Land A, Braakman I (Aug 2001). "Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum". Biochimie. 83 (8): 783–90. doi:10.1016/S0300-9084(01)01314-1. hdl: 1874/5091 . PMID 11530211.
Dedera DA, Gu RL, Ratner L (Mar 1992). "Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function". Virology. 187 (1): 377–82. doi:10.1016/0042-6822(92)90331-I. PMID 1736542.
Moremen KW, Touster O, Robbins PW (Sep 1991). "Novel purification of the catalytic domain of Golgi alpha-mannosidase II. Characterization and comparison with the intact enzyme". The Journal of Biological Chemistry. 266 (25): 16876–85. doi: 10.1016/S0021-9258(18)55384-9 . PMID 1885615.
Kalyanaraman VS, Rodriguez V, Veronese F, Rahman R, Lusso P, DeVico AL, Copeland T, Oroszlan S, Gallo RC, Sarngadharan MG (Mar 1990). "Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1". AIDS Research and Human Retroviruses. 6 (3): 371–80. doi:10.1089/aid.1990.6.371. PMID 2187500.
Shimizu H, Tsuchie H, Honma H, Yoshida K, Tsuruoka T, Ushijima H, Kitamura T (Jun 1990). "Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins". Japanese Journal of Medical Science & Biology. 43 (3): 75–87. doi: 10.7883/yoken1952.43.75 . PMID 2283726.
Leonard CK, Spellman MW, Riddle L, Harris RJ, Thomas JN, Gregory TJ (Jun 1990). "Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells". The Journal of Biological Chemistry. 265 (18): 10373–82. doi: 10.1016/S0021-9258(18)86956-3 . PMID 2355006.
Pal R, Hoke GM, Sarngadharan MG (May 1989). "Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1". Proceedings of the National Academy of Sciences of the United States of America. 86 (9): 3384–8. Bibcode:1989PNAS...86.3384P. doi: 10.1073/pnas.86.9.3384 . PMC 287137 . PMID 2541446.
Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP (Jun 1989). "Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport". Journal of Virology. 63 (6): 2452–6. doi:10.1128/jvi.63.6.2452-2456.1989. PMC 250699 . PMID 2542563.
Kozarsky K, Penman M, Basiripour L, Haseltine W, Sodroski J, Krieger M (1989). "Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein". Journal of Acquired Immune Deficiency Syndromes. 2 (2): 163–9. PMID 2649653.
Robinson WE, Montefiori DC, Mitchell WM (1988). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis". AIDS Research and Human Retroviruses. 3 (3): 265–82. doi:10.1089/aid.1987.3.265. PMID 2829950.
Blough HA, Pauwels R, De Clercq E, Cogniaux J, Sprecher-Goldberger S, Thiry L (Nov 1986). "Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins". Biochemical and Biophysical Research Communications. 141 (1): 33–8. doi:10.1016/S0006-291X(86)80330-8. PMID 3099781.
Montefiori DC, Robinson WE, Mitchell WM (Dec 1988). "Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1". Proceedings of the National Academy of Sciences of the United States of America. 85 (23): 9248–52. Bibcode:1988PNAS...85.9248M. doi: 10.1073/pnas.85.23.9248 . PMC 282716 . PMID 3264072.
Moremen KW, Touster O (Jun 1985). "Biosynthesis and modification of Golgi mannosidase II in HeLa and 3T3 cells". The Journal of Biological Chemistry. 260 (11): 6654–62. doi: 10.1016/S0021-9258(18)88830-5 . PMID 3922977.
Fenouillet E, Jones I, Powell B, Schmitt D, Kieny MP, Gluckman JC (Jan 1993). "Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". Journal of Virology. 67 (1): 150–60. doi:10.1128/jvi.67.1.150-160.1993. PMC 237347 . PMID 8093218.
Yeh JC, Seals JR, Murphy CI, van Halbeek H, Cummings RD (Oct 1993). "Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system". Biochemistry. 32 (41): 11087–99. doi:10.1021/bi00092a019. PMID 8218172.
Velasco A, Hendricks L, Moremen KW, Tulsiani DR, Touster O, Farquhar MG (Jul 1993). "Cell type-dependent variations in the subcellular distribution of alpha-mannosidase I and II". The Journal of Cell Biology. 122 (1): 39–51. doi:10.1083/jcb.122.1.39. PMC 2119607 . PMID 8314846.
Misago M, Liao YF, Kudo S, Eto S, Mattei MG, Moremen KW, Fukuda MN (Dec 1995). "Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme". Proceedings of the National Academy of Sciences of the United States of America. 92 (25): 11766–70. Bibcode:1995PNAS...9211766M. doi: 10.1073/pnas.92.25.11766 . PMC 40483 . PMID 8524845.
Bolmstedt A, Sjölander S, Hansen JE, Akerblom L, Hemming A, Hu SL, Morein B, Olofsson S (Jul 1996). "Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response". Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 12 (3): 213–20. doi:10.1097/00042560-199607000-00001. PMID 8673525.
Hu H, Shioda T, Moriya C, Xin X, Hasan MK, Miyake K, Shimada T, Nagai Y (Nov 1996). "Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface". Journal of Virology. 70 (11): 7462–70. doi:10.1128/jvi.70.11.7462-7470.1996. PMC 190813 . PMID 8892864.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000112893 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1757461-4] Moremen KW, Robbins PW (Dec 1991). "Isolation, characterization, and expression of cDNAs encoding murine alpha-mannosidase II, a Golgi enzyme that controls conversion of high mannose to complex N-glycans". The Journal of Cell Biology. 115 (6): 1521–34. doi:10.1083/jcb.115.6.1521. PMC 2289207 . PMID 1757461.

[pmid15004235-5] Oka T, Ungar D, Hughson FM, Krieger M (May 2004). "The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins". Molecular Biology of the Cell. 15 (5): 2423–35. doi:10.1091/mbc.E03-09-0699. PMC 404034 . PMID 15004235.

[entrez-6] 1 2 "Entrez Gene: MAN2A1 mannosidase, alpha, class 2A, member 1".

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MAN2A1

Contents

Function

Related Research Articles

References

Further reading