MAN2B2

MAN2B2
Identifiers
Aliases	MAN2B2 , mannosidase alpha class 2B member 2, EpMAN
External IDs	MGI: 1195262; HomoloGene: 7411; GeneCards: MAN2B2; OMA:MAN2B2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4p16.1 Start 6,575,189 bp [1] End 6,623,362 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 B3 Start 36,964,265 bp [2] End 36,987,997 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii stromal cell of endometrium Descending thoracic aorta right coronary artery ascending aorta decidua parotid gland synovial joint popliteal artery tibial arteries Top expressed in spermatocyte spermatid granulocyte epithelium of small intestine yolk sac stroma of bone marrow seminiferous tubule tail of embryo ileum primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function catalytic activity hydrolase activity alpha-mannosidase activity metal ion binding hydrolase activity, acting on glycosyl bonds carbohydrate binding mannan endo-1,6-alpha-mannosidase activity Cellular component extracellular region extracellular exosome lysosomal lumen extracellular space vacuolar membrane Biological process metabolism mannose metabolic process protein deglycosylation oligosaccharide catabolic process carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23324 17160 Ensembl ENSG00000013288 ENSMUSG00000029119 UniProt Q9Y2E5 O54782 RefSeq (mRNA) NM_001292038 NM_015274 NM_008550 RefSeq (protein) NP_001278967 NP_056089 NP_032576 Location (UCSC) Chr 4: 6.58 – 6.62 Mb Chr 5: 36.96 – 36.99 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Epididymis-specific alpha-mannosidase is an enzyme that in humans is encoded by the MAN2B2 gene. ^{[5] [6] [7]}

Epididymis-specific alpha-mannosidase precursor

Mannosidase alpha class 2B member

core-specific lysosomal alpha-1,6-Mannosidase

epididymis-specific alpha-mannosidase

mannosidase, alpha, class 2B, member

References

1. GRCh38: Ensembl release 89: ENSG00000013288 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029119 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi: 10.1093/dnares/6.1.63 . PMID   10231032.
6. Park C, Meng L, Stanton LH, Collins RE, Mast SW, Yi X, Strachan H, Moremen KW (Oct 2005). "Characterization of a human core-specific lysosomal {alpha}1,6-mannosidase involved in N-glycan catabolism". J Biol Chem. 280 (44): 37204–16. doi: 10.1074/jbc.M508930200 . PMC   1351102 . PMID   16115860.
7. "Entrez Gene: MAN2B2 mannosidase, alpha, class 2B, member 2".

Further reading

• Land A, Braakman I (2001). "Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum". Biochimie. 83 (8): 783–90. doi:10.1016/S0300-9084(01)01314-1. hdl: 1874/5091 . PMID   11530211. S2CID   13576808.
• Dedera DA, Gu RL, Ratner L (1992). "Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function". Virology. 187 (1): 377–82. doi:10.1016/0042-6822(92)90331-I. PMID   1736542.
• Kalyanaraman VS, Rodriguez V, Veronese F, et al. (1990). "Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1". AIDS Res. Hum. Retroviruses. 6 (3): 371–80. doi:10.1089/aid.1990.6.371. PMID   2187500.
• Shimizu H, Tsuchie H, Honma H, et al. (1991). "Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins". Jpn. J. Med. Sci. Biol. 43 (3): 75–87. doi: 10.7883/yoken1952.43.75 . PMID   2283726.
• Leonard CK, Spellman MW, Riddle L, et al. (1990). "Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells". J. Biol. Chem. 265 (18): 10373–82. doi: 10.1016/S0021-9258(18)86956-3 . PMID   2355006.
• Pal R, Hoke GM, Sarngadharan MG (1989). "Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 86 (9): 3384–8. Bibcode:1989PNAS...86.3384P. doi: 10.1073/pnas.86.9.3384 . PMC   287137 . PMID   2541446.
• Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP (1989). "Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport". J. Virol. 63 (6): 2452–6. doi:10.1128/jvi.63.6.2452-2456.1989. PMC   250699 . PMID   2542563.
• Kozarsky K, Penman M, Basiripour L, et al. (1989). "Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein". J. Acquir. Immune Defic. Syndr. 2 (2): 163–9. PMID   2649653.
• Robinson WE, Montefiori DC, Mitchell WM (1988). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis". AIDS Res. Hum. Retroviruses. 3 (3): 265–82. doi:10.1089/aid.1987.3.265. PMID   2829950.
• Blough HA, Pauwels R, De Clercq E, et al. (1987). "Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins". Biochem. Biophys. Res. Commun. 141 (1): 33–8. doi:10.1016/S0006-291X(86)80330-8. PMID   3099781.
• Montefiori DC, Robinson WE, Mitchell WM (1988). "Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 85 (23): 9248–52. Bibcode:1988PNAS...85.9248M. doi: 10.1073/pnas.85.23.9248 . PMC   282716 . PMID   3264072.
• Fenouillet E, Jones I, Powell B, et al. (1993). "Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–60. doi:10.1128/jvi.67.1.150-160.1993. PMC   237347 . PMID   8093218.
• Yeh JC, Seals JR, Murphy CI, et al. (1993). "Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system". Biochemistry. 32 (41): 11087–99. doi:10.1021/bi00092a019. PMID   8218172.
• Bolmstedt A, Sjölander S, Hansen JE, et al. (1996). "Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (3): 213–20. doi: 10.1097/00042560-199607000-00001 . PMID   8673525.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Hu H, Shioda T, Moriya C, et al. (1996). "Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface". J. Virol. 70 (11): 7462–70. doi:10.1128/jvi.70.11.7462-7470.1996. PMC   190813 . PMID   8892864.
• Papandreou MJ, Fenouillet E (1997). "Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation". FEBS Lett. 406 (1–2): 191–5. doi: 10.1016/S0014-5793(97)00273-1 . PMID   9109416. S2CID   17660.
• Hiramoto S, Tamba M, Kiuchi S, et al. (1998). "Stage-specific expression of a mouse homologue of the porcine 135kDa alpha-D-mannosidase (MAN2B2) in type A spermatogonia". Biochem. Biophys. Res. Commun. 241 (2): 439–45. doi:10.1006/bbrc.1997.7768. PMID   9425289.
• Jin YZ, Dacheux F, Dacheux JL, et al. (1999). "Purification and properties of major alpha-D-mannosidase in the luminal fluid of porcine epididymis". Biochim. Biophys. Acta. 1432 (2): 382–92. doi:10.1016/S0167-4838(99)00117-X. PMID   10407159.