MARS (gene)

MARS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DJV, 4BL7, 4BVX, 4BVY
Identifiers
Aliases	MARS1 , METRS, MRS, MTRNS, SPG70, CMT2U, ILFS2, ILLD, methionyl-tRNA synthetase, methionyl-tRNA synthetase 1, MARS
External IDs	OMIM: 156560 MGI: 1345633 HomoloGene: 90878 GeneCards: MARS1
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q13.3 Start 57,475,445 bp [1] End 57,517,569 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 D3 Start 127,296,221 bp [2] End 127,311,786 bp [2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • aminoacyl-tRNA ligase activity • tRNA binding • nucleotide binding • ligase activity • ATP binding • RNA binding • methionine-tRNA ligase activity Cellular component • extracellular exosome • membrane • nucleolus • cytoplasm • aminoacyl-tRNA synthetase multienzyme complex • cytosol • nucleus Biological process • protein biosynthesis • tRNA aminoacylation for protein translation • cellular response to starvation • rRNA transcription • cellular response to insulin stimulus • cellular response to platelet-derived growth factor stimulus • cellular response to epidermal growth factor stimulus • positive regulation of transcription of nucleolar large rRNA by RNA polymerase I • methionyl-tRNA aminoacylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4141	216443
Ensembl	ENSG00000166986	ENSMUSG00000040354
UniProt	P56192	Q68FL6
RefSeq (mRNA)	NM_004990	NM_001003913 NM_001171582
RefSeq (protein)	NP_004981	NP_001003913 NP_001165053
Location (UCSC)	Chr 12: 57.48 – 57.52 Mb	Chr 10: 127.3 – 127.31 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Methionyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the MARS gene. ^{[5] [6]}

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene belongs to the class I family of tRNA synthetases. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000166986 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040354 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ubeda M, Schmitt-Ney M, Ferrer J, Habener JF (Sep 1999). "CHOP/GADD153 and methionyl-tRNA synthetase (MetRS) genes overlap in a conserved region that controls mRNA stability". Biochem Biophys Res Commun. 262 (1): 31–8. doi:10.1006/bbrc.1999.1140. PMID   10448063.
6. "Entrez Gene: MARS methionyl-tRNA synthetase".

Further reading

• Norcum MT (1991). "Structural analysis of the high molecular mass aminoacyl-tRNA synthetase complex. Effects of neutral salts and detergents". J. Biol. Chem. 266 (23): 15398–405. doi: 10.1016/S0021-9258(18)98629-1 . PMID   1651330.
• Ogata K, Kurahashi A, Kenmochi N, Terao K (1992). "Role of 5SrRNA as a positive effector of some aminoacyl-tRNA synthetases in macromolecular complexes, with specific reference to methionyl-tRNA synthetase". J. Biochem. 110 (6): 1037–44. doi:10.1093/oxfordjournals.jbchem.a123674. PMID   1665486.
• Cirullo RE, Wasmuth JJ (1984). "Assignment of the human MARS gene, encoding methioninyl-tRNA synthetase, to chromosome 12 using human X Chinese hamster cell hybrids". Somat. Cell Mol. Genet. 10 (3): 225–34. doi:10.1007/BF01535245. PMID   6585969. S2CID   44887504.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Lage H, Dietel M (1996). "Cloning of a human cDNA encoding a protein with high homology to yeast methionyl-tRNA synthetase". Gene. 178 (1–2): 187–9. doi:10.1016/0378-1119(96)00313-7. PMID   8921912.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Quevillon S, Robinson JC, Berthonneau E, et al. (1999). "Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein". J. Mol. Biol. 285 (1): 183–95. doi:10.1006/jmbi.1998.2316. PMID   9878398.
• Ko YG, Kang YS, Kim EK, et al. (2000). "Nucleolar Localization of Human Methionyl–Trna Synthetase and Its Role in Ribosomal RNA Synthesis". J. Cell Biol. 149 (3): 567–74. doi:10.1083/jcb.149.3.567. PMC   2174846 . PMID   10791971.
• Kang J, Kim T, Ko YG, et al. (2000). "Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases". J. Biol. Chem. 275 (41): 31682–8. doi: 10.1074/jbc.M909965199 . PMID   10913161.
• Kaminska M, Shalak V, Mirande M (2002). "The appended C-domain of human methionyl-tRNA synthetase has a tRNA-sequestering function". Biochemistry. 40 (47): 14309–16. doi:10.1021/bi015670b. PMID   11714285.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ahn HC, Kim S, Lee BJ (2003). "Solution structure and p43 binding of the p38 leucine zipper motif: coiled-coil interactions mediate the association between p38 and p43". FEBS Lett. 542 (1–3): 119–24. doi: 10.1016/S0014-5793(03)00362-4 . PMID   12729910. S2CID   39222196.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.