MED17

MED17
Identifiers
Aliases	MED17 , CRSP6, CRSP77, DRIP80, TRAP80, mediator complex subunit 17, SRB4
External IDs	OMIM: 603810 MGI: 2182585 HomoloGene: 3151 GeneCards: MED17
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q21 Start 93,784,227 bp [1] End 93,814,963 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 A2 Start 15,171,647 bp [2] End 15,191,227 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve ganglionic eminence Achilles tendon canal of the cervix stromal cell of endometrium smooth muscle tissue cerebellar hemisphere right uterine tube left uterine tube right lobe of thyroid gland Top expressed in secondary oocyte morula endocardial cushion abdominal wall dermis ganglionic eminence medullary collecting duct lacrimal gland ovary epidermis More reference expression data BioGPS n/a
Gene ontology Molecular function transcription coregulator activity thyroid hormone receptor binding protein binding nuclear receptor coactivator activity vitamin D receptor binding transcription coactivator activity signaling receptor activity ubiquitin protein ligase activity Cellular component membrane transcription regulator complex nucleoplasm mediator complex nucleus core mediator complex ubiquitin ligase complex Biological process androgen receptor signaling pathway regulation of transcription, DNA-templated intracellular steroid hormone receptor signaling pathway transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II transcription initiation from RNA polymerase II promoter protein ubiquitination stem cell population maintenance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9440 234959 Ensembl ENSG00000042429 ENSMUSG00000031935 UniProt Q9NVC6 Q8VCD5 RefSeq (mRNA) NM_004268 NM_144933 NM_001364533 RefSeq (protein) NP_004259 NP_659182 NP_001351462 Location (UCSC) Chr 11: 93.78 – 93.81 Mb Chr 9: 15.17 – 15.19 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mediator of RNA polymerase II transcription subunit 17 is an enzyme that in humans is encoded by the MED17 gene. ^{[5] [6] [7]}

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. ^[7]

Interactions

MED17 has been shown to interact with PPARGC1A, ^[8] Cyclin-dependent kinase 8 ^{[6] [9]} and BRCA1. ^{[10] [11] [12]}

References

1. GRCh38: Ensembl release 89: ENSG00000042429 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031935 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ryu S, Zhou S, Ladurner AG, Tjian R (Feb 1999). "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1". Nature. 397 (6718): 446–50. Bibcode:1999Natur.397..446R. doi:10.1038/17141. hdl: 11858/00-001M-0000-0019-A36A-8 . PMID   9989412. S2CID   4405569.
6. Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (Apr 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol Cell. 3 (3): 361–70. doi: 10.1016/S1097-2765(00)80463-3 . PMID   10198638.
7. "Entrez Gene: CRSP6 cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa".
8. Wallberg, Annika E; Yamamura Soichiro; Malik Sohail; Spiegelman Bruce M; Roeder Robert G (Nov 2003). "Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha". Mol. Cell. United States. 12 (5): 1137–49. doi: 10.1016/S1097-2765(03)00391-5 . ISSN   1097-2765. PMID   14636573.
9. Kang, Yun Kyoung; Guermah Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. United States. 99 (5): 2642–7. Bibcode:2002PNAS...99.2642K. doi: 10.1073/pnas.261715899 . ISSN   0027-8424. PMC   122401 . PMID   11867769.
10. Chiba, N; Parvin J D (Oct 2001). "Redistribution of BRCA1 among four different protein complexes following replication blockage". J. Biol. Chem. United States. 276 (42): 38549–54. doi: 10.1074/jbc.M105227200 . ISSN   0021-9258. PMID   11504724.
11. Wada, Osamu; Oishi Hajime; Takada Ichiro; Yanagisawa Junn; Yano Tetsu; Kato Shigeaki (Aug 2004). "BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220". Oncogene. England. 23 (35): 6000–5. doi:10.1038/sj.onc.1207786. ISSN   0950-9232. PMID   15208681.
12. Chiba, Natsuko; Parvin Jeffrey D (Aug 2002). "The BRCA1 and BARD1 association with the RNA polymerase II holoenzyme". Cancer Res. United States. 62 (15): 4222–8. ISSN   0008-5472. PMID   12154023.

Further reading

• Fondell JD, Ge H, Roeder RG (1996). "Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8329–33. Bibcode:1996PNAS...93.8329F. doi: 10.1073/pnas.93.16.8329 . PMC   38670 . PMID   8710870.
• Rachez C, Lemon BD, Suldan Z, et al. (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature. 398 (6730): 824–8. Bibcode:1999Natur.398..824R. doi:10.1038/19783. PMID   10235266. S2CID   204992765.
• Näär AM, Beaurang PA, Zhou S, et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature. 398 (6730): 828–32. Bibcode:1999Natur.398..828N. doi:10.1038/19789. PMID   10235267. S2CID   23646963.
• Chiba N, Parvin JD (2001). "Redistribution of BRCA1 among four different protein complexes following replication blockage". J. Biol. Chem. 276 (42): 38549–54. doi: 10.1074/jbc.M105227200 . PMID   11504724.
• Ge K, Guermah M, Yuan CX, et al. (2002). "Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis". Nature. 417 (6888): 563–7. Bibcode:2002Natur.417..563G. doi:10.1038/417563a. PMID   12037571. S2CID   4432077.
• Wang Q, Sharma D, Ren Y, Fondell JD (2003). "A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression". J. Biol. Chem. 277 (45): 42852–8. doi: 10.1074/jbc.M206061200 . PMID   12218053.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Lau JF, Nusinzon I, Burakov D, et al. (2003). "Role of metazoan mediator proteins in interferon-responsive transcription". Mol. Cell. Biol. 23 (2): 620–8. doi:10.1128/MCB.23.2.620-628.2003. PMC   151539 . PMID   12509459.
• Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". J. Biol. Chem. 278 (17): 15123–7. doi: 10.1074/jbc.C300054200 . PMID   12584197.
• Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". J. Biol. Chem. 278 (50): 49671–4. doi: 10.1074/jbc.C300444200 . PMID   14576168.
• Wallberg AE, Yamamura S, Malik S, et al. (2004). "Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha". Mol. Cell. 12 (5): 1137–49. doi: 10.1016/S1097-2765(03)00391-5 . PMID   14636573.
• Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". J. Biol. Chem. 279 (7): 5846–51. doi: 10.1074/jbc.M312523200 . PMID   14638676.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Sato S, Tomomori-Sato C, Parmely TJ, et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Mol. Cell. 14 (5): 685–91. doi: 10.1016/j.molcel.2004.05.006 . PMID   15175163.
• Wada O, Oishi H, Takada I, et al. (2004). "BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220". Oncogene. 23 (35): 6000–5. doi:10.1038/sj.onc.1207786. PMID   15208681.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Jang MK, Mochizuki K, Zhou M, et al. (2005). "The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription". Mol. Cell. 19 (4): 523–34. doi: 10.1016/j.molcel.2005.06.027 . PMID   16109376.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.