MED7

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MED7
Identifiers
Aliases	MED7 , ARC34, CRSP33, CRSP9, mediator complex subunit 7
External IDs	OMIM: 605045 MGI: 1913463 HomoloGene: 3153 GeneCards: MED7
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q33.3 Start 157,137,424 bp [1] End 157,159,019 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B1.1 Start 46,327,752 bp [2] End 46,333,548 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm germinal epithelium endothelial cell Achilles tendon palpebral conjunctiva kidney tubule corpus epididymis testicle visceral pleura parietal pleura Top expressed in medullary collecting duct secondary oocyte renal corpuscle mirror atrioventricular valve seminiferous tubule medial ganglionic eminence maxillary prominence endocardial cushion urothelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity transcription coregulator activity protein binding ubiquitin protein ligase activity Cellular component mediator complex nucleus transcription regulator complex nucleoplasm ubiquitin ligase complex nuclear body Biological process regulation of transcription by RNA polymerase II stem cell population maintenance transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated protein ubiquitination transcription, DNA-templated positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9443 66213 Ensembl ENSG00000155868 ENSMUSG00000020397 UniProt O43513 Q9CZB6 RefSeq (mRNA) NM_004270 NM_001100816 NM_001104530 NM_001104556 NM_001104557 NM_025426 RefSeq (protein) NP_001094286 NP_004261 NP_001098000 NP_001098026 NP_001098027 NP_079702 Location (UCSC) Chr 5: 157.14 – 157.16 Mb Chr 11: 46.33 – 46.33 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mediator of RNA polymerase II transcription subunit 7 is an enzyme that in humans is encoded by the MED7 gene. ^{[5] [6]}

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000155868 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020397 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ryu S, Zhou S, Ladurner AG, Tjian R (Feb 1999). "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1". Nature. 397 (6718): 446–50. Bibcode:1999Natur.397..446R. doi:10.1038/17141. hdl: 11858/00-001M-0000-0019-A36A-8 . PMID   9989412. S2CID   4405569.
6. "Entrez Gene: CRSP9 cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa".

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Sato S, Tomomori-Sato C, Parmely TJ, et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Mol. Cell. 14 (5): 685–91. doi: 10.1016/j.molcel.2004.05.006 . PMID   15175163.
• Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". J. Biol. Chem. 279 (7): 5846–51. doi: 10.1074/jbc.M312523200 . PMID   14638676.
• Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". J. Biol. Chem. 278 (50): 49671–4. doi: 10.1074/jbc.C300444200 . PMID   14576168.
• Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". J. Biol. Chem. 278 (17): 15123–7. doi: 10.1074/jbc.C300054200 . PMID   12584197.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ryu S, Tjian R (1999). "Purification of transcription cofactor complex CRSP". Proc. Natl. Acad. Sci. U.S.A. 96 (13): 7137–42. Bibcode:1999PNAS...96.7137R. doi: 10.1073/pnas.96.13.7137 . PMC   22029 . PMID   10377381.
• Näär AM, Beaurang PA, Zhou S, et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature. 398 (6730): 828–32. Bibcode:1999Natur.398..828N. doi:10.1038/19789. PMID   10235267. S2CID   23646963.
• Jiang YW, Veschambre P, Erdjument-Bromage H, et al. (1998). "Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8538–43. Bibcode:1998PNAS...95.8538J. doi: 10.1073/pnas.95.15.8538 . PMC   21111 . PMID   9671713.
• Myers LC, Gustafsson CM, Bushnell DA, et al. (1998). "The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain". Genes Dev. 12 (1): 45–54. doi:10.1101/gad.12.1.45. PMC   316402 . PMID   9420330.