MEIOSIN

MEIOSIN
Identifiers
Aliases	MEIOSIN , HMGDC, basic helix-loop-helix and HMG-box containing 1, meiosis initiator, BHMG1
External IDs	MGI: 3647482; GeneCards: MEIOSIN; OMA:MEIOSIN - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.32 Start 45,733,439 bp [1] End 45,764,541 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 A3 Start 18,832,971 bp [2] End 18,852,293 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis gonad right auricle of heart mucosa of esophagus Top expressed in embryo testicle zygote epiblast spermatid genital tubercle mesencephalon neural tube secondary oocyte ventricular zone More reference expression data BioGPS n/a
Gene ontology Molecular function protein dimerization activity DNA binding Cellular component nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 388553 243866 Ensembl ENSG00000237452 ENSMUSG00000085601 UniProt C9JSJ3 A0A5K7RLP0 RefSeq (mRNA) NM_001310124 NM_001370811 NM_001370812 RefSeq (protein) NP_001297053 NP_001357740 NP_001357741 Location (UCSC) Chr 19: 45.73 – 45.76 Mb Chr 7: 18.83 – 18.85 Mb PubMed search [3] [4]
Wikidata
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Meiosis initiator protein is a protein that in humans is encoded by the MEIOSIN gene.

MEIOSIN is a germ cell-specific transcription factor that acts as a gatekeeper of meiotic initiation in mammals, directing the critical switch from mitotic to meiotic cell division. Expressed in response to retinoic acid signaling, MEIOSIN forms a functional complex with STRA8 to directly activate the transcription of essential meiotic genes. This regulatory mechanism governs the timely entry of both male and female germ cells into meiosis, underpinning the formation of haploid gametes necessary for sexual reproduction. Loss of MEIOSIN disrupts meiotic gene activation and leads to infertility due to failure of meiotic progression. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000237452 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000085601 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ishiguro KI, Matsuura K, Tani N, Takeda N, Usuki S, Yamane M, et al. (February 2020). "MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells". Developmental Cell. 52 (4): 429–445.e10. doi:10.1016/j.devcel.2020.01.010. PMID   32032549.
6. Oatley JM, Griswold MD (February 2020). "MEIOSIN: A New Watchman of Meiotic Initiation in Mammalian Germ Cells". Developmental Cell. 52 (4): 397–398. doi:10.1016/j.devcel.2020.02.002. PMC   8555863 . PMID   32097650.
7. Ishiguro KI, Shimada R (June 2022). "MEIOSIN directs initiation of meiosis and subsequent meiotic prophase program during spermatogenesis". Genes & Genetic Systems. 97 (1) 21-00054: 27–39. doi:10.1266/ggs.21-00054. PMID   34955498.