MENTAL domain

Last updated
MENTAL domain
Identifiers
SymbolMENTAL
Pfam PF10457
InterPro IPR019498
PROSITE PS51439
Available protein structures:
Pfam   structures / ECOD  
PDB RCSB PDB; PDBe; PDBj
PDBsum structure summary

The MENTAL or MLN64 NH2-terminal domain is a membrane-spanning domain that is conserved in two late endosomal proteins in vertebrates, MLN64 and MENTHO. [1] The domain is 170 amino acids long.

Current data indicates that this domain allows for dimerization between MLN64 and MENTHO molecules and with themselves. [2] The domain may also direct cholesterol transport.

Related Research Articles

<span class="mw-page-title-main">PTPN11</span> Protein-coding gene in humans

Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), Src homology region 2 domain-containing phosphatase-2 (SHP-2), or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a protein tyrosine phosphatase (PTP) Shp2.

<span class="mw-page-title-main">Erbin (protein)</span> Protein found in humans

Erbb2 interacting protein (ERBB2IP), also known as erbin, is a protein which in humans is encoded by the ERBB2IP gene. Discovered in 1997, erbin is a 200kDa protein containing a PDZ domain.

<span class="mw-page-title-main">ATF1</span> Protein-coding gene in humans

Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.

<span class="mw-page-title-main">RAB3A</span> Protein-coding gene in the species Homo sapiens

Ras-related protein Rab-3A is a protein that in humans is encoded by the RAB3A gene. It is involved in calcium-triggered exocytosis in neurons.

<span class="mw-page-title-main">Sodium-hydrogen exchange regulatory cofactor 2</span> Protein-coding gene in the species Homo sapiens

Sodium-hydrogen exchange regulatory cofactor NHE-RF2 (NHERF-2) also known as tyrosine kinase activator protein 1 (TKA-1) or SRY-interacting protein 1 (SIP-1) is a protein that in humans is encoded by the SLC9A3R2 gene.

<span class="mw-page-title-main">ADAM12</span> Human protein-coding gene

Disintegrin and metalloproteinase domain-containing protein 12 is an enzyme that in humans is encoded by the ADAM12 gene. ADAM12 has two splice variants: ADAM12-L, the long form, has a transmembrane region and ADAM12-S, a shorter variant, is soluble and lacks the transmembrane and cytoplasmic domains.

<span class="mw-page-title-main">NFYB</span> Protein-coding gene in the species Homo sapiens

Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene.

<span class="mw-page-title-main">Myocyte-specific enhancer factor 2A</span> Protein-coding gene in the species Homo sapiens

Myocyte-specific enhancer factor 2A is a protein that in humans is encoded by the MEF2A gene. MEF2A is a transcription factor in the Mef2 family. In humans it is located on chromosome 15q26. Certain mutations in MEF2A cause an autosomal dominant form of coronary artery disease and myocardial infarction.

<span class="mw-page-title-main">PTPN12</span> Protein-coding gene in the species Homo sapiens

Tyrosine-protein phosphatase non-receptor type 12 is an enzyme that in humans is encoded by the PTPN12 gene.

<span class="mw-page-title-main">CAMK1</span> Protein-coding gene in the species Homo sapiens

Calcium/calmodulin-dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene.

<span class="mw-page-title-main">CYTH1</span> Protein-coding gene in the species Homo sapiens

Cytohesin-1 formerly known as Pleckstrin homology, Sec7 and coiled/coil domains 1 (PSCD1) is a protein that in humans is encoded by the CYTH1 gene.

<span class="mw-page-title-main">CLNS1A</span> Protein-coding gene in humans

Methylosome subunit pICln is a protein that in humans is encoded by the CLNS1A gene.

<span class="mw-page-title-main">SNTB1</span> Protein-coding gene in the species Homo sapiens

Beta-1-syntrophin is a protein that in humans is encoded by the SNTB1 gene.

<span class="mw-page-title-main">TRAF4</span> Protein-coding gene in the species Homo sapiens

TNF receptor-associated factor 4 (TRAF4) also known as RING finger protein 83 (RNF83) is a protein that in humans is encoded by the TRAF4 gene.

<span class="mw-page-title-main">LIN7A</span> Protein-coding gene in humans

Lin-7 homolog A is a protein that in humans is encoded by the LIN7A gene.

<span class="mw-page-title-main">LASP1</span> Protein-coding gene in the species Homo sapiens

LIM and SH3 domain protein 1 is a protein that in humans is encoded by the LASP1 gene.

<span class="mw-page-title-main">STARD3NL</span> Protein-coding gene in the species Homo sapiens

MENTHO or STARD3 N-terminal like protein (STARD3NL) is an integral membrane protein of unknown function. As the alternate name implies, MENTHO, short for "MLN64 N-terminal homologue", contains a region in its N-terminus similar to that found in STARD3, also known as MLN64, but lacks the StAR-related transfer domain (START) that characterizes all other proteins given the "STARD" name. The N-terminal domain is called a MENTAL domain.

<span class="mw-page-title-main">Ankyrin-3</span> Protein-coding gene in the species Homo sapiens

Ankyrin-3 (ANK-3), also known as ankyrin-G, is a protein from ankyrin family that in humans is encoded by the ANK3 gene.

A FFAT motif is a protein sequence motif of six defined amino acids plus neighbouring residues that binds to proteins in the VAP protein family.

<span class="mw-page-title-main">Star related lipid transfer domain containing 3</span>

StAR related lipid transfer domain containing 3(STARD3) is a protein that in humans is encoded by the STARD3 gene. STARD3 also known as metastatic lymph node 64 protein (MLN64) is a late endosomal integral membrane protein involved in cholesterol transport. STARD3 creates membrane contact sites between the endoplasmic reticulum (ER) and late endosomes where it moves cholesterol.

References

  1. Alpy F, Wendling C, Rio MC, Tomasetto C (2002). "MENTHO, a MLN64 Homologue Devoid of the START Domain". J. Biol. Chem. 277 (18): 50780–7. doi: 10.1074/jbc.M208290200 . PMID   12393907.
  2. Alpy F, Latchumanan VK, Kedinger V, Janoshazi A, Thiele C, Wendling C, Rio MC, Tomasetto C (2005). "Functional characterization of the MENTAL domain". J. Biol. Chem. 280 (18): 17945–52. doi: 10.1074/jbc.M500723200 . PMID   15718238.