STARD3NL

Last updated
STARD3NL
Identifiers
Aliases STARD3NL , MENTHO, STARD3 N-terminal like
External IDs OMIM: 611759 MGI: 1923455 HomoloGene: 11501 GeneCards: STARD3NL
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024270
NM_001347485

RefSeq (protein)

NP_001334414
NP_077232

Location (UCSC) Chr 7: 38.18 – 38.23 Mb Chr 13: 19.36 – 19.4 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

MENTHO or STARD3 N-terminal like protein (STARD3NL) is an integral membrane protein of unknown function. [5] As the alternate name implies, MENTHO, short for "MLN64 N-terminal homologue", contains a region in its N-terminus similar to that found in STARD3, also known as MLN64, but lacks the StAR-related transfer domain (START) that characterizes all other proteins given the "STARD" (START domain-containing) name. The N-terminal domain is called a MENTAL (MLN64 N-terminal) domain.

Contents

Like MLN64, MENTHO is widely expressed in tissues of the body. Within the cell, it localizes to the membranes of late endosomes and may interact there with MLN64. It is suggested that in combination with MLN64, this protein helps regulate the flow of cholesterol through the endosomal pathway. [6]


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The MENTAL or MLN64 NH2-terminal domain is a membrane-spanning domain that is conserved in two late endosomal proteins in vertebrates, MLN64 and MENTHO. The domain is 170 amino acids long.

<span class="mw-page-title-main">Star related lipid transfer domain containing 3</span>

StAR related lipid transfer domain containing 3(STARD3) is a protein that in humans is encoded by the STARD3 gene. STARD3 also known as metastatic lymph node 64 protein (MLN64) is a late endosomal integral membrane protein involved in cholesterol transport. STARD3 creates membrane contact sites between the endoplasmic reticulum (ER) and late endosomes where it moves cholesterol.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000010270 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003062 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: STARD3NL STARD3 N-terminal like".
  6. Alpy F, Tomasetto C (2006). "MLN64 and MENTHO, two mediators of endosomal cholesterol transport". Biochem. Soc. Trans. 34 (Pt 3): 343–5. doi:10.1042/BST0340343. PMID   16709157.

Further reading