MES207

MES207

Identifiers
IUPAC name 4-anilino-1-benzyl-N-[2-(diaminomethylideneamino)ethyl]piperidine-4-carboxamide
PubChem CID	101882819
IUPHAR/BPS	11235
ChemSpider	58129784
ChEMBL	ChEMBL3361425
Chemical and physical data
Formula	C22H30N6O
Molar mass	394.523 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1CN(CCC1(C(=O)NCCN=C(N)N)NC2=CC=CC=C2)CC3=CC=CC=C3
InChI InChI=1S/C22H30N6O/c23-21(24)26-14-13-25-20(29)22(27-19-9-5-2-6-10-19)11-15-28(16-12-22)17-18-7-3-1-4-8-18/h1-10,27H,11-17H2,(H,25,29)(H4,23,24,26) Key:SCPYAGLHLAAYFP-UHFFFAOYSA-N

MES207 is a drug used in scientific research which acts as a potent and selective antagonist for the neuropeptide FF receptor NPFF1, with 17x selectivity over the closely related receptor NPFF2. It prevented opioid-induced hyperalgesia in animal models. ^{[1] [2]}

References

1. Journigan VB, Mésangeau C, Vyas N, Eans SO, Cutler SJ, McLaughlin JP, et al. (November 2014). "Nonpeptide small molecule agonist and antagonist original leads for neuropeptide FF1 and FF2 receptors". Journal of Medicinal Chemistry. 57 (21): 8903–8927. doi:10.1021/jm500989n. PMC   4234442 . PMID   25268943.
2. King TI, Roewekamp AC, Sharma A, Harrison S, Mesangeau C, Mottinelli M, et al. (December 2019). "Bioanalytical method development and validation of MES207, a neuropeptide FF receptor antagonist, and its application in preclinical pharmacokinetics". Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1134–1135 121875. doi:10.1016/j.jchromb.2019.121875. PMC   7027589 . PMID   31790916.