METTL1

METTL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CKK
Identifiers
Aliases	METTL1 , C12orf1, TRM8, TRMT8, YDL201w, methyltransferase like 1, methyltransferase 1, tRNA methylguanosine
External IDs	OMIM: 604466; MGI: 1339986; HomoloGene: 3918; GeneCards: METTL1; OMA:METTL1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q14.1 Start 57,768,471 bp [1] End 57,772,119 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 D3 Start 127,041,414 bp [2] End 127,046,365 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas gonad pancreatic ductal cell left adrenal cortex right adrenal gland testicle right lobe of thyroid gland right adrenal cortex stromal cell of endometrium left lobe of thyroid gland Top expressed in lacrimal gland yolk sac epiblast embryo blastocyst embryo right kidney morula proximal tubule primitive streak More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity transferase activity tRNA binding tRNA (guanine-N7-)-methyltransferase activity protein binding RNA binding Cellular component tRNA methyltransferase complex nucleolus nucleus nucleoplasm cytosol Biological process methylation tRNA modification tRNA processing tRNA (guanine-N7)-methylation tRNA methylation RNA (guanine-N7)-methylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4234 17299 Ensembl ENSG00000037897 ENSMUSG00000006732 UniProt Q9UBP6 Q9Z120 RefSeq (mRNA) NM_005371 NM_023032 NM_023033 NM_010792 RefSeq (protein) NP_005362 NP_075422 NP_034922 Location (UCSC) Chr 12: 57.77 – 57.77 Mb Chr 10: 127.04 – 127.05 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

tRNA (guanine-N(7)-)-methyltransferase is an enzyme that in humans is encoded by the METTL1 gene. ^{[5] [6]}

This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms and transcript variants utilizing alternative polyA sites have been described in the literature. ^[6]

See also

• 7-Methylguanosine

References

1. GRCh38: Ensembl release 89: ENSG00000037897 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000006732 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bahr A, Hankeln T, Fiedler T, Hegemann J, Schmidt ER (Aug 1999). "Molecular analysis of METTL1, a novel human methyltransferase-like gene with a high degree of phylogenetic conservation". Genomics. 57 (3): 424–8. doi:10.1006/geno.1999.5780. PMID   10329009.
6. "Entrez Gene: METTL1 methyltransferase like 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Alexandrov A, Martzen MR, Phizicky EM (2002). "Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA". RNA. 8 (10): 1253–66. doi:10.1017/S1355838202024019. PMC   1370335 . PMID   12403464.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID   12539042. S2CID   26145639.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Cartlidge RA, Knebel A, Peggie M, et al. (2005). "The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells". EMBO J. 24 (9): 1696–705. doi:10.1038/sj.emboj.7600648. PMC   1142581 . PMID   15861136.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.