MGAT3

MGAT3
Identifiers
Aliases	MGAT3 , GNT-III, GNT3, mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
External IDs	OMIM: 604621; MGI: 104532; HomoloGene: 31088; GeneCards: MGAT3; OMA:MGAT3 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q13.1 Start 39,457,012 bp [1] End 39,492,194 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15 E1|15 37.85 cM Start 80,057,922 bp [2] End 80,099,720 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe prefrontal cortex Brodmann area 9 olfactory bulb nucleus accumbens cingulate gyrus dorsal motor nucleus of vagus nerve amygdala anterior cingulate cortex Top expressed in dentate gyrus of hippocampal formation granule cell superior frontal gyrus right kidney primary visual cortex cerebellar cortex proximal tubule supraoptic nucleus lumbar subsegment of spinal cord facial motor nucleus ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity glycosyltransferase activity beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity Cellular component integral component of membrane Golgi membrane Golgi apparatus membrane Biological process protein glycosylation protein N-linked glycosylation N-acetylglucosamine metabolic process protein localization regulation of cell migration cellular response to oxidative stress amyloid-beta metabolic process cognition positive regulation of protein localization to early endosome negative regulation of lysosomal protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4248 17309 Ensembl ENSG00000128268 ENSMUSG00000042428 UniProt Q09327 Q10470 Q5RKT9 RefSeq (mRNA) NM_001098270 NM_002409 NM_010795 RefSeq (protein) NP_001091740 NP_002400 NP_034925 Location (UCSC) Chr 22: 39.46 – 39.49 Mb Chr 15: 80.06 – 80.1 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT3 gene. ^{[5] [6]}

There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000128268 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042428 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ihara Y, Nishikawa A, Tohma T, Soejima H, Niikawa N, Taniguchi N (Oct 1993). "cDNA cloning, expression, and chromosomal localization of human N-acetylglucosaminyltransferase III (GnT-III)". J Biochem. 113 (6): 692–8. doi:10.1093/oxfordjournals.jbchem.a124105. PMID   8370666.
6. "Entrez Gene: MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase".

Further reading

• Kim YJ, Park JH, Kim KS, et al. (1996). "Sequence analysis of the 5'-flanking region of the gene encoding human N-acetylglucosaminyltransferase III". Gene. 170 (2): 281–3. doi:10.1016/0378-1119(95)00818-7. PMID   8666260.
• Koyama N, Miyoshi E, Ihara Y, et al. (1996). "Human N-acetylglucosaminyltransferase III gene is transcribed from multiple promoters". Eur. J. Biochem. 238 (3): 853–61. doi: 10.1111/j.1432-1033.1996.0853w.x . PMID   8706690.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Ikeda Y, Koyota S, Ihara H, et al. (2000). "Kinetic basis for the donor nucleotide-sugar specificity of beta1, 4-N-acetylglucosaminyltransferase III". J. Biochem. 128 (4): 609–19. doi: 10.1093/oxfordjournals.jbchem.a022793 . PMID   11011143.
• Song EY, Kang SK, Lee YC, et al. (2002). "Expression of bisecting N-acetylglucosaminyltransferase-III in human hepatocarcinoma tissues, fetal liver tissues, and hepatoma cell lines of Hep3B and HepG2". Cancer Invest. 19 (8): 799–807. doi:10.1081/CNV-100107741. PMID   11768033. S2CID   22792562.
• Shibukawa Y, Takahashi M, Laffont I, et al. (2003). "Down-regulation of hydrogen peroxide-induced PKC delta activation in N-acetylglucosaminyltransferase III-transfected HeLaS3 cells". J. Biol. Chem. 278 (5): 3197–203. doi: 10.1074/jbc.M207870200 . PMID   12427758.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Sasai K, Ikeda Y, Ihara H, et al. (2003). "Caveolin-1 regulates the functional localization of N-acetylglucosaminyltransferase III within the golgi apparatus". J. Biol. Chem. 278 (28): 25295–301. doi: 10.1074/jbc.M301913200 . PMID   12716887.
• Millar JK, Christie S, Porteous DJ (2004). "Yeast two-hybrid screens implicate DISC1 in brain development and function". Biochem. Biophys. Res. Commun. 311 (4): 1019–25. doi:10.1016/j.bbrc.2003.10.101. PMID   14623284.
• Isaji T, Gu J, Nishiuchi R, et al. (2004). "Introduction of bisecting GlcNAc into integrin alpha5beta1 reduces ligand binding and down-regulates cell adhesion and cell migration". J. Biol. Chem. 279 (19): 19747–54. doi: 10.1074/jbc.M311627200 . PMID   14998999.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC   545604 . PMID   15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Fiala M, Liu PT, Espinosa-Jeffrey A, et al. (2007). "Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin". Proc. Natl. Acad. Sci. U.S.A. 104 (31): 12849–54. Bibcode:2007PNAS..10412849F. doi: 10.1073/pnas.0701267104 . PMC   1937555 . PMID   17652175.