MGAT4B

Last updated
MGAT4B
Identifiers
Aliases MGAT4B , GNT-IV, GNT-IVB, mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B, alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
External IDs OMIM: 604561; MGI: 2143974; HomoloGene: 8611; GeneCards: MGAT4B; OMA:MGAT4B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_054013
NM_014275

NM_145926

RefSeq (protein)

NP_055090
NP_463459

NP_666038

Location (UCSC) Chr 5: 179.8 – 179.81 Mb Chr 11: 50.1 – 50.13 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B is an enzyme that in humans is encoded by the MGAT4B gene. [5] [6]

This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. Therefore, the protein is essential for the production of tri- and tetra-antennary sugar chains. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [6] Its affinities for donors of acceptors are lower than that of MGAT4A so it is suggested that it is not the main contributor in N-glycan biosynthesis. [7]

References

  1. 1 2 3 ENSG00000161013 GRCh38: Ensembl release 89: ENSG00000284501, ENSG00000161013 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036620 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Yoshida A, Minowa MT, Takamatsu S, Hara T, Ikenaga H, Takeuchi M (Jul 1999). "A novel second isoenzyme of the human UDP-N-acetylglucosamine:alpha1,3-D-mannoside beta1,4-N-acetylglucosaminyltransferase family: cDNA cloning, expression, and chromosomal assignment". Glycoconj J. 15 (12): 1115–23. doi:10.1023/A:1006951519522. PMID   10372966. S2CID   31297495.
  6. 1 2 "Entrez Gene: MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B".
  7. Q9UQ53

Further reading