MGAT5B

MGAT5B
Identifiers
Aliases	MGAT5B , GnT-IX, GnT-VB, mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B, alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
External IDs	OMIM: 612441; MGI: 3606200; HomoloGene: 27821; GeneCards: MGAT5B; OMA:MGAT5B - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q25.2 Start 76,868,404 bp [1] End 76,950,393 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 E2 Start 116,809,689 bp [2] End 116,877,774 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe Brodmann area 9 oocyte cingulate gyrus anterior cingulate cortex putamen prefrontal cortex caudate nucleus nucleus accumbens amygdala Top expressed in dentate gyrus of hippocampal formation granule cell superior frontal gyrus primary visual cortex lumbar subsegment of spinal cord ventricular zone ganglionic eminence medial dorsal nucleus superior colliculus piriform cortex lateral geniculate nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity protein binding metal ion binding glycosyltransferase activity alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity manganese ion binding Cellular component integral component of membrane Golgi membrane membrane Golgi apparatus Biological process protein glycosylation protein N-linked glycosylation protein O-linked glycosylation via serine Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 146664 268510 Ensembl ENSG00000167889 ENSMUSG00000043857 UniProt Q3V5L5 Q765H6 RefSeq (mRNA) NM_001199172 NM_144677 NM_198955 NM_172948 RefSeq (protein) NP_001186101 NP_653278 NP_945193 NP_766536 Location (UCSC) Chr 17: 76.87 – 76.95 Mb Chr 11: 116.81 – 116.88 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B is an enzyme that in humans is encoded by the MGAT5B gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000167889 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043857 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Inamori K, Endo T, Gu J, Matsuo I, Ito Y, Fujii S, Iwasaki H, Narimatsu H, Miyoshi E, Honke K, Taniguchi N (Jan 2004). "N-Acetylglucosaminyltransferase IX acts on the GlcNAc beta 1,2-Man alpha 1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan". J Biol Chem. 279 (4): 2337–2340. doi: 10.1074/jbc.C300480200 . PMID   14617637.
6. Kaneko M, Alvarez-Manilla G, Kamar M, Lee I, Lee JK, Troupe K, Zhang W, Osawa M, Pierce M (Nov 2003). "A novel beta(1,6)-N-acetylglucosaminyltransferase V (GnT-VB)(1)". FEBS Lett. 554 (3): 515–519. doi: 10.1016/S0014-5793(03)01234-1 . PMID   14623122. S2CID   82207739.
7. "Entrez Gene: MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B".

Further reading

• Land A, Braakman I (2001). "Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum". Biochimie. 83 (8): 783–790. doi:10.1016/S0300-9084(01)01314-1. hdl: 1874/5091 . PMID   11530211. S2CID   13576808.
• Abbott KL, Troupe K, Lee I, Pierce M (2006). "Integrin-dependent neuroblastoma cell adhesion and migration on laminin is regulated by expression levels of two enzymes in the O-mannosyl-linked glycosylation pathway, PomGnT1 and GnT-Vb". Exp. Cell Res. 312 (15): 2837–2850. doi:10.1016/j.yexcr.2006.05.022. PMID   16857188.
• Lee I, Guo HB, Kamar M, et al. (2006). "N-acetylglucosaminyltranferase VB expression enhances beta1 integrin- dependent PC12 neurite outgrowth on laminin and collagen". J. Neurochem. 97 (4): 947–956. doi: 10.1111/j.1471-4159.2006.03785.x . PMID   16606368. S2CID   22339355.
• Inamori K, Mita S, Gu J, et al. (2006). "Demonstration of the expression and the enzymatic activity of N-acetylglucosaminyltransferase IX in the mouse brain". Biochim. Biophys. Acta. 1760 (4): 678–684. doi:10.1016/j.bbagen.2005.11.019. PMID   16413118.
• Guo HB, Lee I, Kamar M, Pierce M (2004). "N-acetylglucosaminyltransferase V expression levels regulate cadherin-associated homotypic cell-cell adhesion and intracellular signaling pathways". J. Biol. Chem. 278 (52): 52412–52424. doi: 10.1074/jbc.M308837200 . PMID   14561752.
• Inamori K, Endo T, Ide Y, et al. (2003). "Molecular cloning and characterization of human GnT-IX, a novel beta1,6-N-acetylglucosaminyltransferase that is specifically expressed in the brain". J. Biol. Chem. 278 (44): 43102–43109. doi: 10.1074/jbc.M308255200 . PMID   12941944.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Papandreou MJ, Fenouillet E (1997). "Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation". FEBS Lett. 406 (1–2): 191–195. doi: 10.1016/S0014-5793(97)00273-1 . PMID   9109416. S2CID   17660.
• Bolmstedt A, Sjölander S, Hansen JE, et al. (1996). "Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (3): 213–20. doi: 10.1097/00042560-199607000-00001 . PMID   8673525.
• Fenouillet E, Jones I, Powell B, et al. (1993). "Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–60. doi:10.1128/jvi.67.1.150-160.1993. PMC   237347 . PMID   8093218.
• Montefiori DC, Robinson WE, Mitchell WM (1988). "Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 85 (23): 9248–9252. Bibcode:1988PNAS...85.9248M. doi: 10.1073/pnas.85.23.9248 . PMC   282716 . PMID   3264072.
• Blough HA, Pauwels R, De Clercq E, et al. (1987). "Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins". Biochem. Biophys. Res. Commun. 141 (1): 33–38. doi:10.1016/S0006-291X(86)80330-8. PMID   3099781.
• Robinson WE, Montefiori DC, Mitchell WM (1988). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis". AIDS Res. Hum. Retroviruses. 3 (3): 265–282. doi:10.1089/aid.1987.3.265. PMID   2829950.
• Kozarsky K, Penman M, Basiripour L, et al. (1989). "Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein". J. Acquir. Immune Defic. Syndr. 2 (2): 163–9. PMID   2649653.
• Pal R, Hoke GM, Sarngadharan MG (1989). "Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 86 (9): 3384–3388. Bibcode:1989PNAS...86.3384P. doi: 10.1073/pnas.86.9.3384 . PMC   287137 . PMID   2541446.
• Kalyanaraman VS, Rodriguez V, Veronese F, et al. (1990). "Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1". AIDS Res. Hum. Retroviruses. 6 (3): 371–380. doi:10.1089/aid.1990.6.371. PMID   2187500.
• Dedera DA, Gu RL, Ratner L (1992). "Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function". Virology. 187 (1): 377–382. doi:10.1016/0042-6822(92)90331-I. PMID   1736542.