MGAT5B

MGAT5B
Identifiers
Aliases	MGAT5B , GnT-IX, GnT-VB, mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B, alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
External IDs	OMIM: 612441 MGI: 3606200 HomoloGene: 27821 GeneCards: MGAT5B
Gene location (Human)
Chr.	Chromosome 17 (human)
End	76,950,393 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	116,877,774 bp
RNA expression pattern
	Top expressed in
	Brodmann area 9; ; oocyte; ; cingulate gyrus; ; putamen; ; prefrontal cortex; ; caudate nucleus; ; nucleus accumbens; ; amygdala; ; superior frontal gyrus; ; secondary oocyte;
	Top expressed in
	superior frontal gyrus; ; ganglionic eminence; ; medial dorsal nucleus; ; superior colliculus; ; piriform cortex; ; lateral geniculate nucleus; ; cerebellar cortex; ; inferior colliculus; ; medial geniculate nucleus; ; olfactory bulb;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity ; protein binding ; metal ion binding ; glycosyltransferase activity ; alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity ; manganese ion binding ;
Cellular component	integral component of membrane ; Golgi membrane ; membrane ; Golgi apparatus ;
Biological process	protein glycosylation ; protein N-linked glycosylation ; protein O-linked glycosylation via serine ;
	Sources:Amigo / QuickGO
Orthologs
	146664
	268510
	ENSG00000167889
	ENSMUSG00000043857
	Q3V5L5
	Q765H6
	NM_001199172 ; NM_144677 ; NM_198955
	NM_172948
	NP_001186101 ; NP_653278 ; NP_945193
	NP_766536
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 13, 2023

Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B is an enzyme that in humans is encoded by the MGAT5B gene.^[5]^[6]^[7]

Related Research Articles

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Alpha-mannosidase 2 is an enzyme that in humans is encoded by the MAN2A1 gene.

Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT2 gene.

Beta-1,4-galactosyltransferase 2 is an enzyme that in humans is encoded by the B4GALT2 gene.

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B is an enzyme that in humans is encoded by the MGAT4B gene.

Glycoprotein endo-alpha-1,2-mannosidase is an enzyme that in humans is encoded by the MANEA gene.

Epididymis-specific alpha-mannosidase is an enzyme that in humans is encoded by the MAN2B2 gene.

Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA is an enzyme that in humans is encoded by the MAN1A1 gene.

Mannosyl-oligosaccharide glucosidase is an enzyme that in humans is encoded by the MOGS gene.

Beta-1,4-galactosyltransferase 4 is an enzyme that in humans is encoded by the B4GALT4 gene.

β-Mannosidase is an enzyme with systematic name β-D-mannoside mannohydrolase, which is in humans encoded by the MANBA gene. This enzyme catalyses the following chemical reaction

GBA2 is the gene that encodes the enzyme non-lysosomal glucosylceramidase in humans. It has glucosylceramidase activity.

Beta-1,4-galactosyltransferase 3 is an enzyme that in humans is encoded by the B4GALT3 gene.

Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB is an enzyme that in humans is encoded by the MAN1A2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000167889 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043857 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Inamori K, Endo T, Gu J, Matsuo I, Ito Y, Fujii S, Iwasaki H, Narimatsu H, Miyoshi E, Honke K, Taniguchi N (Jan 2004). "N-Acetylglucosaminyltransferase IX acts on the GlcNAc beta 1,2-Man alpha 1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan". J Biol Chem. 279 (4): 2337–2340. doi: 10.1074/jbc.C300480200 . PMID 14617637.
↑ Kaneko M, Alvarez-Manilla G, Kamar M, Lee I, Lee JK, Troupe K, Zhang W, Osawa M, Pierce M (Nov 2003). "A novel beta(1,6)-N-acetylglucosaminyltransferase V (GnT-VB)(1)". FEBS Lett. 554 (3): 515–519. doi: 10.1016/S0014-5793(03)01234-1 . PMID 14623122. S2CID 82207739.
↑ "Entrez Gene: MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B".

Land A, Braakman I (2001). "Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum". Biochimie. 83 (8): 783–790. doi:10.1016/S0300-9084(01)01314-1. hdl: 1874/5091 . PMID 11530211. S2CID 13576808.
Abbott KL, Troupe K, Lee I, Pierce M (2006). "Integrin-dependent neuroblastoma cell adhesion and migration on laminin is regulated by expression levels of two enzymes in the O-mannosyl-linked glycosylation pathway, PomGnT1 and GnT-Vb". Exp. Cell Res. 312 (15): 2837–2850. doi:10.1016/j.yexcr.2006.05.022. PMID 16857188.
Lee I, Guo HB, Kamar M, et al. (2006). "N-acetylglucosaminyltranferase VB expression enhances beta1 integrin- dependent PC12 neurite outgrowth on laminin and collagen". J. Neurochem. 97 (4): 947–956. doi: 10.1111/j.1471-4159.2006.03785.x . PMID 16606368. S2CID 22339355.
Inamori K, Mita S, Gu J, et al. (2006). "Demonstration of the expression and the enzymatic activity of N-acetylglucosaminyltransferase IX in the mouse brain". Biochim. Biophys. Acta. 1760 (4): 678–684. doi:10.1016/j.bbagen.2005.11.019. PMID 16413118.
Guo HB, Lee I, Kamar M, Pierce M (2004). "N-acetylglucosaminyltransferase V expression levels regulate cadherin-associated homotypic cell-cell adhesion and intracellular signaling pathways". J. Biol. Chem. 278 (52): 52412–52424. doi: 10.1074/jbc.M308837200 . PMID 14561752.
Inamori K, Endo T, Ide Y, et al. (2003). "Molecular cloning and characterization of human GnT-IX, a novel beta1,6-N-acetylglucosaminyltransferase that is specifically expressed in the brain". J. Biol. Chem. 278 (44): 43102–43109. doi: 10.1074/jbc.M308255200 . PMID 12941944.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Papandreou MJ, Fenouillet E (1997). "Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation". FEBS Lett. 406 (1–2): 191–195. doi: 10.1016/S0014-5793(97)00273-1 . PMID 9109416. S2CID 17660.
Bolmstedt A, Sjölander S, Hansen JE, et al. (1996). "Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (3): 213–20. doi: 10.1097/00042560-199607000-00001 . PMID 8673525.
Fenouillet E, Jones I, Powell B, et al. (1993). "Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–60. doi:10.1128/jvi.67.1.150-160.1993. PMC 237347 . PMID 8093218.
Montefiori DC, Robinson WE, Mitchell WM (1988). "Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 85 (23): 9248–9252. Bibcode:1988PNAS...85.9248M. doi: 10.1073/pnas.85.23.9248 . PMC 282716 . PMID 3264072.
Blough HA, Pauwels R, De Clercq E, et al. (1987). "Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins". Biochem. Biophys. Res. Commun. 141 (1): 33–38. doi:10.1016/S0006-291X(86)80330-8. PMID 3099781.
Robinson WE, Montefiori DC, Mitchell WM (1988). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis". AIDS Res. Hum. Retroviruses. 3 (3): 265–282. doi:10.1089/aid.1987.3.265. PMID 2829950.
Kozarsky K, Penman M, Basiripour L, et al. (1989). "Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein". J. Acquir. Immune Defic. Syndr. 2 (2): 163–9. PMID 2649653.
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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000167889 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043857 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14617637-5] Inamori K, Endo T, Gu J, Matsuo I, Ito Y, Fujii S, Iwasaki H, Narimatsu H, Miyoshi E, Honke K, Taniguchi N (Jan 2004). "N-Acetylglucosaminyltransferase IX acts on the GlcNAc beta 1,2-Man alpha 1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan". J Biol Chem. 279 (4): 2337–2340. doi: 10.1074/jbc.C300480200 . PMID 14617637.

[pmid14623122-6] Kaneko M, Alvarez-Manilla G, Kamar M, Lee I, Lee JK, Troupe K, Zhang W, Osawa M, Pierce M (Nov 2003). "A novel beta(1,6)-N-acetylglucosaminyltransferase V (GnT-VB)(1)". FEBS Lett. 554 (3): 515–519. doi: 10.1016/S0014-5793(03)01234-1 . PMID 14623122. S2CID 82207739.

[entrez-7] "Entrez Gene: MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B".

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MGAT5B

Related Research Articles

References

Further reading