Microsomal glutathione S-transferase 2 is an enzyme that in humans is encoded by the MGST2 gene. [5] [6]
The MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein that catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. [6]
Thromboxane A synthase 1 , also known as TBXAS1, is a cytochrome P450 enzyme that, in humans, is encoded by the TBXAS1 gene.
Leukotriene C4 (LTC4) is a leukotriene. LTC4 has been extensively studied in the context of allergy and asthma. In cells of myeloid origin such as mast cells, its biosynthesis is orchestrated by translocation to the nuclear envelope along with co-localization of cytosolic phospholipase A2 (cPLA2), arachidonate 5-lipoxygenase (5-LO), 5-lipoxygenase-activating protein (FLAP) and LTC4 synthase (LTC4S), which couples glutathione to an LTA4 intermediate. The MRP1 transporter then secretes cytosolic LTC4 and cell surface proteases further metabolize it by sequential cleavage of the γ-glutamyl and glycine residues off its glutathione segment, generating the more stable products LTD4 and LTE4. All three leukotrienes then bind at different affinities to two G-protein coupled receptors: CYSLTR1 and CYSLTR2, triggering pulmonary vasoconstriction and bronchoconstriction.
Prostaglandin E synthase is an enzyme involved in eicosanoid and glutathione metabolism, a member of MAPEG family. It generates prostaglandin E (PGE) from prostaglandin H2.
Leukotriene C4 synthase is an enzyme that in humans is encoded by the LTC4S gene.
Glutathione S-transferase P is an enzyme that in humans is encoded by the GSTP1 gene.
Glutathione S-transferase A1 is an enzyme that in humans is encoded by the GSTA1 gene.
Cysteinyl leukotriene receptor 1, also termed CYSLTR1, is a receptor for cysteinyl leukotrienes (LT). CYSLTR1, by binding these cysteinyl LTs contributes to mediating various allergic and hypersensitivity reactions in humans as well as models of the reactions in other animals.
Glutathione S-transferase A2 is an enzyme that in humans is encoded by the GSTA2 gene.
Glutathione S-transferase Mu 2 is an enzyme that in humans is encoded by the GSTM2 gene.
Glutathione S-transferase M3 (brain), also known as GSTM2, is an enzyme which in humans is encoded by the GSTM99 gene.
Glutathione S-transferase A4, also known as GSTA4, is an enzyme which in humans is encoded by the GSTA4 gene.
Glutathione S-transferase Mu 4 is an enzyme that in humans is encoded by the GSTM4 gene.
Microsomal glutathione S-transferase 1 is an enzyme that in humans is encoded by the MGST1 gene.
Glutathione S-transferase omega-1 is an enzyme that in humans is encoded by the GSTO1 gene.
PGDS protein is a protein that in humans is encoded by the HPGDS gene.
In molecular biology the MAPEG family of proteins are a group of membrane associated proteins with highly divergent functions. Included are the 5-lipoxygenase-activating protein, leukotriene C4 synthase, which catalyzes the production of leukotriene C4 (LTC4) from leukotriene A4 (LTA4), and microsomal glutathione S-transferase II (GST-II), which also produces LTC4 from LTA4.
Microsomal prostaglandin E synthase-1 (mPGES-1) or Prostaglandin E synthase is an enzyme that in humans is encoded by the PTGES gene.
Gamma-glutamyltransferase 5 is an enzyme that in humans is encoded by the GGT5 gene.
Microsomal glutathione S-transferase 3 is an enzyme that in humans is encoded by the MGST3 gene.
Dehydrodolichyl diphosphate synthase is an enzyme that in humans is encoded by the DHDDS gene.
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