MIR7-1

MIR7-1
Identifiers
Aliases	MIR7-1 , MIRN7-1, hsa-mir-7-1, mir-7-1, MicroRNA 7-1
External IDs	OMIM: 615239 GeneCards: MIR7-1
Gene location (Human)
Chr.	Chromosome 9 (human)
End	83,969,857 bp
RNA expression pattern
	Top expressed in
	kidney; ; blood; ; adrenal gland; ; liver; ; left lobe of thyroid gland; ; adipose tissue; ; body of pancreas; ; islet of Langerhans; ; muscle of leg; ; gastrocnemius muscle;
	n/a
	More reference expression data
	n/a
Orthologs
	407043
	n/a
	ENSG00000284179
	n/a
	n ; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Last updated December 04, 2023

MicroRNA 7-1 is a microRNA molecule that in humans is encoded by the MIR7-1 gene.^[3]

Function

microRNAs, or miRNAs, are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

Related Research Articles

Drosha is a Class 2 ribonuclease III enzyme that in humans is encoded by the DROSHA gene. It is the primary nuclease that executes the initiation step of miRNA processing in the nucleus. It works closely with DGCR8 and in correlation with Dicer. It has been found significant in clinical knowledge for cancer prognosis and HIV-1 replication.

This family represents the microRNA (miRNA) precursor mir-7. This miRNA has been predicted or experimentally confirmed in a wide range of species. miRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 5' arm of the precursor. The extents of the hairpin precursors are not generally known and are estimated based on hairpin prediction. The involvement of Dicer in miRNA processing suggests a relationship with the phenomenon of RNA interference.

microRNA 21 also known as hsa-mir-21 or miRNA21 is a mammalian microRNA that is encoded by the MIR21 gene.

In molecular biology mir-126 is a short non-coding RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several pre- and post-transcription mechanisms.

In molecular biology mir-22 microRNA is a short RNA molecule. MicroRNAs are an abundant class of molecules, approximately 22 nucleotides in length, which can post-transcriptionally regulate gene expression by binding to the 3' UTR of mRNAs expressed in a cell.

In molecular biology, mir-221 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

miR-138 is a family of microRNA precursors found in animals, including humans. MicroRNAs are typically transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. The excised region or, mature product, of the miR-138 precursor is the microRNA mir-138.

In molecular biology mir-365 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

In molecular biology mir-491 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

mir-618 microRNA is a short non-coding RNA molecule belonging both to the family of microRNAs and to that of small interfering RNAs (siRNAs). MicroRNAs function to regulate the expression levels of other genes by several mechanisms, whilst siRNAs are involved primarily with the RNA interference (RNAi) pathway.

MicroRNA 34a (miR-34a) is a MicroRNA that in humans is encoded by the MIR34A gene.

MicroRNA 7-2 is a non-protein-coding gene product that in humans is encoded by the MIR7-2 gene.

MicroRNA 138-1 is a protein that in humans is encoded by the MIR138-1 gene.

MicroRNA 489 is a miRNA that in humans is encoded by the MIR489 gene.

MicroRNA 499a is a non-coding RNA that in humans is encoded by the MIR499A gene.

MicroRNA 106a is a microRNA that in humans is encoded by the MIR106A gene.

MicroRNA 495 is a protein that in humans is encoded by the MIR495 gene.

MicroRNA 141 is a non-coding RNA molecule that in humans is encoded by the MIR141 gene.

MicroRNA 195 is a protein that in humans is encoded by the MIR195 gene.

MicroRNA 93 is a functional RNA and a microRNA that in humans is encoded by the MIR93 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000284179 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: MicroRNA 7-1". National Center for Biotechnology Information . National Institutes of Health . Retrieved 26 December 2013.

Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP (March 2003). "Vertebrate microRNA genes". Science. 299 (5612): 1540. doi:10.1126/science.1080372. PMID 12624257. S2CID 37750545.
Correa-Medina M, Bravo-Egana V, Rosero S, Ricordi C, Edlund H, Diez J, Pastori RL (April 2009). "MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas". Gene Expression Patterns. 9 (4): 193–9. doi:10.1016/j.gep.2008.12.003. PMID 19135553.
Chen AX, Yu KD, Fan L, Li JY, Yang C, Huang AJ, Shao ZM (September 2011). Horwitz MS (ed.). "Germline genetic variants disturbing the Let-7/LIN28 double-negative feedback loop alter breast cancer susceptibility". PLOS Genetics. 7 (9): e1002259. doi: 10.1371/journal.pgen.1002259 . PMC 3164678 . PMID 21912531.
Xu L, Wen Z, Zhou Y, Liu Z, Li Q, Fei G, Luo J, Ren T (January 2013). "MicroRNA-7-regulated TLR9 signaling-enhanced growth and metastatic potential of human lung cancer cells by altering the phosphoinositide-3-kinase, regulatory subunit 3/Akt pathway". Molecular Biology of the Cell. 24 (1): 42–55. doi:10.1091/mbc.E12-07-0519. PMC 3530778 . PMID 23135998.
Kefas B, Godlewski J, Comeau L, Li Y, Abounader R, Hawkinson M, Lee J, Fine H, Chiocca EA, Lawler S, Purow B (May 2008). "microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma". Cancer Research. 68 (10): 3566–72. doi: 10.1158/0008-5472.CAN-07-6639 . PMID 18483236.
Bravo-Egana V, Rosero S, Molano RD, Pileggi A, Ricordi C, Domínguez-Bendala J, Pastori RL (February 2008). "Quantitative differential expression analysis reveals miR-7 as major islet microRNA". Biochemical and Biophysical Research Communications. 366 (4): 922–6. doi:10.1016/j.bbrc.2007.12.052. PMC 4104201 . PMID 18086561.
Chen ZX, Sun AM, Chen Y, Liu Y, Zhan JF, Chen LH, Yuan YW (August 2010). "[Effects of radiosensitivity and X-ray dose on miR-7 expression in nasopharyngeal carcinoma]". Nan Fang Yi Ke da Xue Xue Bao = Journal of Southern Medical University. 30 (8): 1810–2, 1816. PMID 20813671.
Kredo-Russo S, Ness A, Mandelbaum AD, Walker MD, Hornstein E (2012). "Regulation of pancreatic microRNA-7 expression". Experimental Diabetes Research. 2012: 695214. doi: 10.1155/2012/695214 . PMC 3362837 . PMID 22675342.
Wang Y, Liu J, Liu C, Naji A, Stoffers DA (March 2013). "MicroRNA-7 regulates the mTOR pathway and proliferation in adult pancreatic β-cells". Diabetes. 62 (3): 887–95. doi:10.2337/db12-0451. PMC 3581216 . PMID 23223022.
Midgley AC, Bowen T, Phillips AO, Steadman R (April 2014). "MicroRNA-7 inhibition rescues age-associated loss of epidermal growth factor receptor and hyaluronan-dependent differentiation in fibroblasts". Aging Cell. 13 (2): 235–44. doi:10.1111/acel.12167. PMC 4331777 . PMID 24134702.
Midgley AC, Morris G, Phillips AO, Steadman R (June 2016). "17β-estradiol ameliorates age-associated loss of fibroblast function by attenuating IFN-γ/STAT1-dependent miR-7 upregulation". Aging Cell. 15 (3): 531–41. doi:10.1111/acel.12462. PMC 4854905 . PMID 26931423.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000284179 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: MicroRNA 7-1". National Center for Biotechnology Information . National Institutes of Health . Retrieved 26 December 2013.

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MIR7-1

Contents

Function

Related Research Articles

References

Further reading