MOV10

MOV10
Identifiers
Aliases	MOV10 , fSAP113, gb110, Mov10 RISC complex RNA helicase
External IDs	OMIM: 610742; MGI: 97054; HomoloGene: 10365; GeneCards: MOV10; OMA:MOV10 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p13.2 Start 112,673,141 bp [1] End 112,700,756 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F2.2 Start 104,702,152 bp [2] End 104,725,879 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis right uterine tube anterior pituitary right lobe of liver granulocyte skin of arm skin of abdomen mucosa of transverse colon right adrenal cortex Top expressed in blastocyst granulocyte tail of embryo yolk sac genital tubercle gallbladder duodenum ankle joint zygote ileum More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding helicase activity protein binding hydrolase activity ATP binding RNA binding 5'-3' RNA helicase activity Cellular component cytoplasm P-body extracellular space cytosol nucleus cytoplasmic stress granule cytoplasmic ribonucleoprotein granule P granule Biological process regulation of transcription, DNA-templated transcription, DNA-templated mRNA destabilization-mediated gene silencing by miRNA gene silencing Wnt signaling pathway, calcium modulating pathway gene silencing by miRNA regulation of megakaryocyte differentiation negative regulation of transposition, RNA-mediated positive regulation of gene expression negative regulation of gene expression RNA interference positive regulation of mRNA catabolic process 3'-UTR-mediated mRNA destabilization regulation of neuron projection arborization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4343 17454 Ensembl ENSG00000155363 ENSMUSG00000002227 UniProt Q9HCE1 P23249 RefSeq (mRNA) NM_001130079 NM_001286072 NM_020963 NM_001321324 NM_001369507 NM_001389562 NM_001389563 NM_001163440 NM_001163441 NM_008619 RefSeq (protein) NP_001123551 NP_001273001 NP_001308253 NP_066014 NP_001356436 NP_001156912 NP_001156913 NP_032645 Location (UCSC) Chr 1: 112.67 – 112.7 Mb Chr 3: 104.7 – 104.73 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Putative helicase MOV-10 is an enzyme that in humans is encoded by the MOV10 gene. ^[5] Stability of MOV10 protein is controlled via DCAF12 ubiquitin ligase. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000155363 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002227 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: MOV10 Mov10, Moloney leukemia virus 10, homolog (mouse)".
6. Lidak, Tomas (20 May 2021). "CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation". Int J Mol Sci. 22 (10): 5394. doi: 10.3390/ijms22105394 . PMC   8161014 . PMID   34065512.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi: 10.1093/dnares/7.4.271 . PMID   10997877.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Meister G, Landthaler M, Peters L, et al. (2006). "Identification of novel argonaute-associated proteins". Curr. Biol. 15 (23): 2149–55. doi:10.1016/j.cub.2005.10.048. hdl: 11858/00-001M-0000-0012-E763-B . PMID   16289642. S2CID   2740901.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.