MPHOSPH8

MPHOSPH8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LWE, 3QO2, 3R93, 3SVM
Identifiers
Aliases	MPHOSPH8 , HSMPP8, TWA3, mpp8, M-phase phosphoprotein 8
External IDs	OMIM: 611626 MGI: 1922589 HomoloGene: 11380 GeneCards: MPHOSPH8
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q12.11 Start 19,633,659 bp [1] End 19,673,441 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 C3 Start 56,905,705 bp [2] End 56,934,887 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon sural nerve canal of the cervix cerebellar hemisphere gastric mucosa popliteal artery right lung right coronary artery secondary oocyte lymph node Top expressed in secondary oocyte facial motor nucleus primitive streak spermatocyte substantia nigra condyle fossa ciliary body trigeminal ganglion pontine nuclei More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methylated histone binding protein binding ubiquitin protein ligase binding ubiquitin-protein transferase activity chromatin binding Cellular component cytoplasm plasma membrane nucleolus nucleus chromosome ubiquitin ligase complex cytosol heterochromatin Biological process regulation of DNA methylation negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated protein ubiquitination negative regulation of gene expression, epigenetic positive regulation of DNA methylation-dependent heterochromatin assembly negative regulation of single stranded viral RNA replication via double stranded DNA intermediate Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54737 75339 Ensembl ENSG00000196199 ENSMUSG00000079184 UniProt Q99549 Q3TYA6 RefSeq (mRNA) NM_017520 NM_023773 NM_001360072 RefSeq (protein) NP_059990 NP_076262 NP_001347001 Location (UCSC) Chr 13: 19.63 – 19.67 Mb Chr 14: 56.91 – 56.93 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

M-phase phosphoprotein 8 is an enzyme that in humans is encoded by the MPHOSPH8 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000196199 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000079184 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Matsumoto-Taniura N, Pirollet F, Monroe R, Gerace L, Westendorf JM (Jan 1997). "Identification of novel M phase phosphoproteins by expression cloning". Mol Biol Cell. 7 (9): 1455–69. doi:10.1091/mbc.7.9.1455. PMC   275994 . PMID   8885239.
6. "Entrez Gene: HSMPP8 M-phase phosphoprotein, mpp8".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983.
• Maksimov VV, Arman IP, Tarantul VZ (2006). "[Identification of the proteins interacting with neuroprotective peptide humanin in a yeast two-hybrid system]". Genetika. 42 (2): 274–7. PMID   16583711.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC   2665288 . PMID   15057823.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Umeda M, Nishitani H, Nishimoto T (2003). "A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM". Gene. 303: 47–54. doi:10.1016/S0378-1119(02)01153-8. PMID   12559565.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.