MSRB2

MSRB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L1U
Identifiers
Aliases	MSRB2 , CBS-1, CBS1, MSRB, PILB, CGI-131, methionine sulfoxide reductase B2
External IDs	OMIM: 613782 MGI: 1923717 HomoloGene: 56555 GeneCards: MSRB2
Gene location (Human)
Chr.	Chromosome 10 (human)
End	23,122,013 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	19,399,787 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; vena cava; ; left ventricle; ; biceps brachii; ; triceps brachii muscle; ; thoracic diaphragm; ; saphenous vein; ; body of tongue; ; nucleus accumbens; ; optic nerve;
	Top expressed in
	interventricular septum; ; myocardium of ventricle; ; cardiac muscles; ; right ventricle; ; proximal tubule; ; cervix; ; skeletal muscle tissue; ; brown adipose tissue; ; kidney; ; facial motor nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity ; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor ; oxidoreductase activity ; actin binding ; zinc ion binding ; metal ion binding ; peptide-methionine (R)-S-oxide reductase activity ; L-methionine-(R)-S-oxide reductase activity ;
Cellular component	cytosol ; mitochondrion ;
Biological process	actin filament polymerization ; response to oxidative stress ; protein repair ; regulation of transcription, DNA-templated ; cellular response to oxidative stress ;
	Sources:Amigo / QuickGO
Orthologs
	22921
	76467
	ENSG00000148450
	ENSMUSG00000023094
	Q9Y3D2
	Q78J03
	NM_012228
	NM_029619
	NP_036360
	NP_083895
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2022

Methionine-R-sulfoxide reductase B2, mitochondrial is an enzyme that in humans is encoded by the MSRB2 gene.^[5]^[6]^[7] The MRSB2 enzyme catalyzes the reduction of methionine sulfoxide to methionine.

Related Research Articles

In the inner ear, stereocilia are the mechanosensing organelles of hair cells, which respond to fluid motion in numerous types of animals for various functions, including hearing and balance. They are about 10–50 micrometers in length and share some similar features of microvilli. The hair cells turn the fluid pressure and other mechanical stimuli into electric stimuli via the many microvilli that make up stereocilia rods. Stereocilia exist in the auditory and vestibular systems.

Sepiapterin reductase is an enzyme that in humans is encoded by the SPR gene.

Bile salt-dependent lipase, also known as carboxyl ester lipase is an enzyme produced by the adult pancreas and aids in the digestion of fats. Bile salt-stimulated lipase is an equivalent enzyme found within breast milk. BSDL has been found in the pancreatic secretions of all species in which it has been looked for. BSSL, originally discovered in the milk of humans and various other primates, has since been found in the milk of many animals including dogs, cats, rats, and rabbits.

<span class="mw-page-title-main">CALCRL</span> Mammalian protein found in Homo sapiens

Calcitonin receptor-like (CALCRL), also known as the calcitonin receptor-like receptor (CRLR), is a human protein; it is a receptor for calcitonin gene-related peptide.

In enzymology, a peptide-methionine (R)-S-oxide reductase (EC 1.8.4.12) is an enzyme that catalyzes the chemical reaction

Cytochrome b5, form A, is a human microsomal cytochrome b5.

Tyrosine-protein phosphatase non-receptor type 13 is an enzyme that in humans is encoded by the PTPN13 gene.

Semenogelin-1 is a protein that in humans is encoded by the SEMG1 gene. The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. The prostate-specific antigen (PSA) protease processes this protein into smaller peptides, with each possibly having a separate function. The proteolysis process breaks down the gel matrix and allows the spermatozoa to move more freely. Two transcript variants encoding different isoforms have been found for this gene.

Legumain is a protein that in humans is encoded by the LGMN gene.

Sodium- and chloride-dependent taurine transporter is a protein that in humans is encoded by the SLC6A6 gene.

3-keto-steroid reductase is an enzyme that in humans is encoded by the HSD17B7 gene.

Sodium- and chloride-dependent glycine transporter 2, also known as glycine transporter 2 (GlyT2), is a protein that in humans is encoded by the SLC6A5 gene.

Kappa-casein is a protein that in humans is encoded by the CSN3 gene.

Peptide methionine sulfoxide reductase (Msr) is a family of enzymes that in humans is encoded by the MSRA gene.

Cathepsin W is a protein that in humans is encoded by the CTSW gene.

Plasminogen-related protein B is a protein that in humans is encoded by the PLGLB2 gene.

40S ribosomal protein S15 is a protein that in humans is encoded by the RPS15 gene.

Methionine-R-sulfoxide reductase B1 is an enzyme that in humans is encoded by the SEPX1 gene.

Methionine sulfoxide is the organic compound with the formula CH₃S(O)CH₂CH₂CH(NH₂)CO₂H. It is an amino acid that occurs naturally although it is formed post-translationally.

Peptide-methionine (S)-S-oxide reductase (EC 1.8.4.11, MsrA, methionine sulphoxide reductase A, methionine S-oxide reductase (S-form oxidizing), methionine sulfoxide reductase A, peptide methionine sulfoxide reductase, formerly protein-methionine-S-oxide reductase) is an enzyme with systematic name peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase (L-methionine (S)-S-oxide-forming). This enzyme catalyses the following chemical reaction

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000148450 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023094 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Escribano J, Ortego J, Coca-Prados M (Jan 1997). "Isolation and characterization of cell-specific cDNA clones from a subtractive library of the ocular ciliary body of a single normal human donor: transcription and synthesis of plasma proteins". J Biochem. 118 (5): 921–31. doi:10.1093/jb/118.5.921. PMID 8749308.
↑ Huang W, Escribano J, Sarfarazi M, Coca-Prados M (Aug 1999). "Identification, expression and chromosome localization of a human gene encoding a novel protein with similarity to the pilB family of transcriptional factors (pilin) and to bacterial peptide methionine sulfoxide reductases". Gene. 233 (1–2): 233–40. doi:10.1016/S0378-1119(99)00131-6. PMID 10375640.
↑ "Entrez Gene: MSRB2 methionine sulfoxide reductase B2".

Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876 . PMID 10810093.
Jung S, Hansel A, Kasperczyk H, et al. (2002). "Activity, tissue distribution and site-directed mutagenesis of a human peptide methionine sulfoxide reductase of type B: hCBS1". FEBS Lett. 527 (1–3): 91–4. doi: 10.1016/S0014-5793(02)03171-X . PMID 12220640. S2CID 2170229.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Kim HY, Gladyshev VN (2004). "Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases". Mol. Biol. Cell. 15 (3): 1055–64. doi:10.1091/mbc.E03-08-0629. PMC 363075 . PMID 14699060.
Picot CR, Perichon M, Cintrat JC, et al. (2004). "The peptide methionine sulfoxide reductases, MsrA and MsrB (hCBS-1), are downregulated during replicative senescence of human WI-38 fibroblasts". FEBS Lett. 558 (1–3): 74–8. doi:10.1016/S0014-5793(03)01530-8. PMID 14759519. S2CID 32573388.
Hansel A, Jung S, Hoshi T, Heinemann SH (2004). "A second human methionine sulfoxide reductase (hMSRB2) reducing methionine-R-sulfoxide displays a tissue expression pattern distinct from hMSRB1". Redox Rep. 8 (6): 384–8. doi: 10.1179/135100003225003429 . PMID 14980072.
Schallreuter KU, Rübsam K, Chavan B, et al. (2006). "Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus". Biochem. Biophys. Res. Commun. 342 (1): 145–52. doi:10.1016/j.bbrc.2006.01.124. PMID 16480945.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000148450 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023094 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8749308-5] Escribano J, Ortego J, Coca-Prados M (Jan 1997). "Isolation and characterization of cell-specific cDNA clones from a subtractive library of the ocular ciliary body of a single normal human donor: transcription and synthesis of plasma proteins". J Biochem. 118 (5): 921–31. doi:10.1093/jb/118.5.921. PMID 8749308.

[pmid10375640-6] Huang W, Escribano J, Sarfarazi M, Coca-Prados M (Aug 1999). "Identification, expression and chromosome localization of a human gene encoding a novel protein with similarity to the pilB family of transcriptional factors (pilin) and to bacterial peptide methionine sulfoxide reductases". Gene. 233 (1–2): 233–40. doi:10.1016/S0378-1119(99)00131-6. PMID 10375640.

[entrez-7] "Entrez Gene: MSRB2 methionine sulfoxide reductase B2".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

MSRB2

Contents

See also

Related Research Articles

References

Further reading