MT1H

MT1H
Identifiers
Aliases	MT1H , MT-0, MT-1H, MT-IH, MT1, metallothionein 1H
External IDs	OMIM: 156354; HomoloGene: 136530; GeneCards: MT1H; OMA:MT1H - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q13 Start 56,669,814 bp [1] End 56,671,129 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum mucosa of transverse colon kidney tubule buccal mucosa cell metanephric glomerulus external globus pallidus cartilage tissue pericardium internal globus pallidus olfactory bulb n/a More reference expression data BioGPS n/a
Gene ontology Molecular function zinc ion binding protein binding metal ion binding Cellular component cytoplasm perinuclear region of cytoplasm nucleus Biological process negative regulation of growth cellular response to cadmium ion cellular response to zinc ion cellular zinc ion homeostasis detoxification of copper ion cellular response to copper ion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4496 n/a Ensembl ENSG00000205358 n/a UniProt P80294 n/a RefSeq (mRNA) NM_005951 n/a RefSeq (protein) NP_005942 n/a Location (UCSC) Chr 16: 56.67 – 56.67 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Metallothionein-1H is a protein that in humans is encoded by the MT1H gene. ^{[3] [4] [5]}

References

1. GRCh38: Ensembl release 89: ENSG00000205358 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. West AK, Stallings R, Hildebrand CE, Chiu R, Karin M, Richards RI (Mar 1991). "Human metallothionein genes: structure of the functional locus at 16q13". Genomics. 8 (3): 513–8. doi:10.1016/0888-7543(90)90038-V. PMID   2286373.
4. Stennard FA, Holloway AF, Hamilton J, West AK (Sep 1994). "Characterisation of six additional human metallothionein genes". Biochim Biophys Acta. 1218 (3): 357–65. doi:10.1016/0167-4781(94)90189-9. PMID   8049263.
5. "Entrez Gene: MT1H metallothionein 1H".

Further reading

• Soumillion A, Van Damme J, De Ley M (1992). "Cloning and specific polymerised-chain-reaction amplification of a third charge-separable human metallothionein isoform". Eur. J. Biochem. 209 (3): 999–1004. doi: 10.1111/j.1432-1033.1992.tb17374.x . PMID   1425708.
• Pauwels M, van Weyenbergh J, Soumillion A, et al. (1994). "Induction by zinc of specific metallothionein isoforms in human monocytes". Eur. J. Biochem. 220 (1): 105–10. doi: 10.1111/j.1432-1033.1994.tb18603.x . PMID   8119276.
• Mididoddi S, McGuirt JP, Sens MA, et al. (1996). "Isoform-specific expression of metallothionein mRNA in the developing and adult human kidney". Toxicol. Lett. 85 (1): 17–27. doi:10.1016/0378-4274(96)03632-6. PMID   8619255.
• Vandeghinste N, Proost P, De Ley M (2000). "Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes". Cell. Mol. Biol. (Noisy-le-grand). 46 (2): 419–33. PMID   10774930.
• Nguyen A, Jing Z, Mahoney PS, et al. (2000). "In vivo gene expression profile analysis of metallothionein in renal cell carcinoma". Cancer Lett. 160 (2): 133–40. doi:10.1016/S0304-3835(00)00534-6. PMID   11053642.
• Rahman MT, Vandingenen A, De Ley M (2000). "Metallothionein biosynthesis in human RBC precursors". Cell. Physiol. Biochem. 10 (4): 237–42. doi:10.1159/000016355. PMID   11093034. S2CID   22377545.
• Chen Y, Irie Y, Keung WM, Maret W (2002). "S-nitrosothiols react preferentially with zinc thiolate clusters of metallothionein III through transnitrosation". Biochemistry. 41 (26): 8360–7. doi:10.1021/bi020030+. PMID   12081484.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID   12539042. S2CID   26145639.
• Cui YP, Wang JB, Zhang XY, et al. (2003). "Using yeast two-hybrid system to identify ECRG2 associated proteins and their possible interactions with ECRG2 gene". World J. Gastroenterol. 9 (9): 1892–6. doi: 10.3748/wjg.v9.i9.1892 . PMC   4656638 . PMID   12970870.
• Kroczynska B, Evangelista CM, Samant SS, et al. (2004). "The SANT2 Domain of the Murine Tumor Cell DnaJ-like Protein 1 Human Homologue Interacts with α1-Antichymotrypsin and Kinetically Interferes with Its Serpin Inhibitory Activity". J. Biol. Chem. 279 (12): 11432–43. doi: 10.1074/jbc.M310903200 . PMC   1553221 . PMID   14668352.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Sun NN, Fastje CD, Wong SS, et al. (2005). "Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line". Toxicology and Industrial Health. 19 (7–10): 157–63. doi:10.1191/0748233703th185oa. PMID   15747776. S2CID   14394243.