MUBII-TB-DB

Last updated
MUBII-TB-DB
Content
DescriptionA database that documents and tracks tuberculosis antibiotic resistance genes.
Data types
captured		Tuberculosis antibiotic resistance genes
Organisms Bacteria
Contact
Primary citation PMID   24731071
Access
Website umr5558-bibiserv.univ-lyon1.fr/mubii/mubii-select.cgi
Miscellaneous
Bookmarkable
entities		yes

MUBII-TB-DB is a database that focuses on tuberculosis antibiotic resistance genes. [1] It is a highly structured, text-based database focusing on Mycobacterium tuberculosis at seven different mutation loci: rpoB, pncA, katG; mabA(fabG1)-inhA, gyrA, gyrB, and rrs. [1] [2] [3] [4] [5] MUBII analyzes the query using two parallel strategies: 1). A BLAST search against previously mutated sequences. 2). Alignment of query sequences with wild-type sequences. MUBII outputs graphs of alignments and description of the mutation and therapeutic significance. [1] Therapeutically relevant mutations are tagged as "High-Confident" based on the criteria set by Sandgren et al. [6] MUBII-TB-DB provides a platform that is easy to use for even users that are not trained in bioinformatics. [1]

See also

References

  1. 1 2 3 4 Flandrois, Jean-Pierre; Lina, Gérard; Dumitrescu, Oana (December 2014). "MUBII-TB-DB: a database of mutations associated with antibiotic resistance in Mycobacterium tuberculosis". BMC Bioinformatics. 15 (1): 107. doi: 10.1186/1471-2105-15-107 . ISSN   1471-2105. PMC   4021062 . PMID   24731071.
  2. ↑ Heym, B (February 1997). "Multidrug resistance in Mycobacterium tuberculosis". International Journal of Antimicrobial Agents. 8 (1): 61–70. doi:10.1016/s0924-8579(96)00356-1. ISSN   0924-8579. PMID   18611785.
  3. ↑ Musser, J M (October 1995). "Antimicrobial agent resistance in mycobacteria: molecular genetic insights". Clinical Microbiology Reviews. 8 (4): 496–514. doi:10.1128/cmr.8.4.496. ISSN   0893-8512. PMC   172873 . PMID   8665467.
  4. ↑ Almeida Da Silva, P. E.; Palomino, J. C. (2011-07-01). "Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs". Journal of Antimicrobial Chemotherapy. 66 (7): 1417–1430. doi: 10.1093/jac/dkr173 . ISSN   0305-7453. PMID   21558086.
  5. ↑ Zhang, Y.; Yew, W-W. (2015-11-01). "Mechanisms of drug resistance in Mycobacterium tuberculosis: update 2015". The International Journal of Tuberculosis and Lung Disease. 19 (11): 1276–1289. doi:10.5588/ijtld.15.0389. ISSN   1027-3719. PMID   26467578.
  6. ↑ Sandgren, Andreas; Strong, Michael; Muthukrishnan, Preetika; Weiner, Brian K; Church, George M; Murray, Megan B (2009-02-10). "Tuberculosis Drug Resistance Mutation Database". PLOS Medicine. 6 (2) e1000002. doi: 10.1371/journal.pmed.1000002 . ISSN   1549-1676. PMC   2637921 . PMID   19209951.


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