The Malaghan Institute of Medical Research is an independent biomedical research institute based in Wellington, New Zealand. The Malaghan Institute specialises in the immune system, and how it can be harnessed to improve human health. Its key areas of research and discovery are cancer, asthma and allergy, infectious disease, gut health and brain health. In 2019, the Institute began New Zealand's first clinical trial [1] of CAR T-cell therapy, trialling a third-generation CAR T-cell therapy in partnership with Wellington Zhaotai Therapies.
The concept of a Wellington-based, independent medical research institute was first proposed in the early 1960s. At that time, relatively little medical research was carried out in New Zealand due to a lack of facilities and support by hospital boards. Using funds from a trust established by the Wellington Medical Research Foundation and the Wellington Division of the Cancer Society, the Wellington Cancer and Medical Research Institute was opened on 26 July 1979, in rented premises in the Wellington School of Medicine. In 1986, the name of the Institute was changed to the Malaghan Institute of Medical Research in recognition of the generous support by Len Malaghan, the co-founder of Tip Top Ice Cream Ltd (later General Foods) and his wife Ann, whose gift of 100,000 shares in the company seeded the Institute. [2] Len died of cancer in 1967 at the relatively young age of 61. [3]
The Institute is a registered charity, relying on support from the community, the corporate sector and contestable grants.
In 2004 the Institute relocated to a purpose-built facility at Victoria University of Wellington.
The founding Director was Dr William Stehbens. Current Director Professor Graham Le Gros was appointed Research Director of the Malaghan Institute in 1994, following a three-year Fogarty Fellowship at the National Institutes of Health, Washington DC, and a five-year scientist position with Ciba-Geigy in Basel, Switzerland. [4] [5] In 2014 he was made a Companion of the New Zealand Order of Merit for his services to medical research. [6]
The Institute won the supreme The Dominion Post Gold Award for 2014, [7] recognising its 30-year history of finding better treatments for cancer, asthma and allergies. [8]
Omalizumab, sold under the brand name Xolair, is an injectable medication to treat severe persistent allergic forms of asthma, nasal polyps, urticaria (hives), and immunoglobulin E-mediated food allergy.
The University of Otago, Wellington is one of seven component schools that make up the University of Otago Division of Health Sciences. All University of Otago medical students who gain entry after a competitive Health Sciences First Year programme, or who gain graduate entry, spend their second and third years studying in Dunedin in a programme called Early Learning in Medicine (ELM), which is jointly taught by the Otago Medical School and the School of Biomedical Sciences. In their fourth, fifth, and sixth years, medical students study at one of three clinical schools: either Otago Medical School or the University of Otago, Christchurch or the University of Otago, Wellington.
Sir Albert William Liley was a New Zealand medical practitioner, renowned for developing techniques to improve the health of foetuses in utero.
Wellington Hospital, also known as Wellington Regional Hospital, is the main hospital in Wellington, New Zealand, located south of the city centre in the suburb of Newtown. It is the main hospital run by Te Whatu Ora, Capital, Coast and Hutt Valley.
Michael Vivian Berridge is a New Zealand cell biologist. Since 1976, he has led the cancer cell and molecular biology research group at the Malaghan Institute of Medical Research. He is also a professor at Victoria University of Wellington and a Distinguished Research Fellow at the Malaghan Institute of Medical Research. He is best known for elucidating cellular mechanisms of reduction of tetrazolium dyes that are widely used in biology, and for the discovery of mitochondrial genome transfer from healthy cells to mitochondrial DNA-deficient cancer cells.
The Firestone Institute for Respiratory Health (FIRH) is a center for the investigation and treatment of respiratory diseases. Based out of St. Joseph's Healthcare in Hamilton, Ontario, Canada, the institute is a clinical facility with strong research directions. FIRH faculty are also heavily involved at McMaster University with education at the undergraduate, graduate, post-graduate and continuing medical education levels.
Benaroya Research Institute (BRI) is a Seattle, Washington non-profit organization that conducts medical research on many diseases and immune disorders, including autoimmune disease. It is affiliated with Virginia Mason Health System, and is located on the campus of Virginia Mason Medical Center.
Kari C. Nadeau is the Chair of the Department of Environmental Health at Harvard School of Public Health and John Rock Professor of Climate and Population Studies. She is adjunct professor at Stanford University in the Department of Pediatrics and the co-chair of the Medical Societies Consortium for Climate Change and Health. She practices Allergy, Asthma, Immunology in children and adults. She has published over 400+ papers, many in the field of climate change and health. Her team focuses on quantifying health outcomes of solutions as they pertain climate change mitigation and adaptation at the local, regional, country, and global levels. Dr. Nadeau, with a team of individuals and patients and families, has been able to help major progress and impact in the clinical fields of immunology, infection, asthma, and allergy. Dr. Nadeau is a member of the National Academy of Medicine and the U.S. EPA Children’s Health Protection Committee.
James Douglas Watson was a New Zealand biotechnologist and entrepreneur.
Dianne Christine McCarthy is a New Zealand scientist and professional director, who was the chief executive of the Royal Society of New Zealand between 2007 and 2014. She lives in Blenheim.
Franca Ronchese is an Italian-New Zealand immunologist. She currently leads the immune cell biology programme at the Malaghan Institute of Medical Research in Wellington, New Zealand and is a research professor at Victoria University of Wellington.
Monica Innes Asher is a New Zealand paediatrician. She is professor of paediatrics at the University of Auckland.
The Capital and Coast District Health Board (CCDHB) was a district health board with the focus on providing healthcare to Wellington City, Porirua City and the Kāpiti Coast in New Zealand. The CCDHB employed about 6000 people across the Wellington Region. It was disestablished on 1 July 2022, with its functions and responsibilities being taken over by the national health service Te Whatu Ora.
Charles Richard William Beasley is a New Zealand academic physician, the founder and Director of the Medical Research Institute of New Zealand, and as of 2019 is a full professor at the Victoria University of Wellington.
Giorgio Walter Canonica is an Italian allergist, pulmonologist and professor of Respiratory Medicine at Humanitas University, Milan, Italy and Director Personalized Medicine Asthma & Allergy Center at Humanitas Research Hospital IRCCS-Milano Italy since December 2016. He is known for his research work related to innovative treatment strategies for allergic diseases which includes biological response modifier in form of targeted immunotherapy with primary emphasis on sublingual immunotherapy (SLIT). He has served as Secretary General and President elect of World Allergy Organisation for six consecutive years and has served as president of the same organization during 2007–09. He is also the vice-president of INTERASMA.
Graham Stephen Le Gros is a New Zealand immunologist. He is currently Director of the Malaghan Institute of Medical Research in Wellington, New Zealand and leads its Allergic and Parasitic Diseases Programme. He is also Research Director of the Vaccine Alliance Aotearoa New Zealand – Ohu Kaupare Huaketo and a Research Professor at Victoria University of Wellington.
Dianne Sika-Paotonu is a New Zealand immunologist, biomedical scientist and academic in the Department of Pathology and Molecular Medicine and Associate Dean (Pacific) at the University of Otago Wellington. She is of Tongan descent and is the first Pasifika biomedical scientist to receive the Cranwell Medal for science communication in 2020 and the 2022 Prime Minister's Science Communicator of the Year prize.
John William Holloway is a geneticist based at the University of Southampton, where he is professor of allergy and respiratory genetics, and was appointed associate vice-president interdisciplinary research in 2021. He leads a research team based within the human genetics and medical genomics theme of the School of Human Development & Health, Faculty of Medicine. Holloway is a Fellow of the Higher Education Academy.
Rebecca Grainger is a New Zealand academic rheumatologist, and is a full professor at the University of Otago, specialising in rheumatoid arthritis and osteoarthritis, and gout. She is also interested in the use of technology for medical education and digital health.
41°17′28″S174°46′06″E / 41.291065°S 174.768376°E