Mammaglobin-B

SCGB2A1
Identifiers
Aliases	SCGB2A1 , LPHC, LPNC, MGB2, UGB3, secretoglobin family 2A member 1
External IDs	OMIM: 604398 HomoloGene: 88664 GeneCards: SCGB2A1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	62,213,943 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; right uterine tube; ; caput epididymis; ; bronchial epithelial cell; ; endometrium; ; palpebral conjunctiva; ; pancreatic ductal cell; ; rectum; ; left uterine tube; ; salivary gland;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein heterodimerization activity ;
Cellular component	extracellular space ; extracellular region ;
Biological process	androgen receptor signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	4246
	n/a
	ENSG00000124939
	n/a
	O75556
	n/a
	NM_002407
	n/a
	NP_002398
	n/a
	Wikidata
View/Edit Human

Last updated March 04, 2023

Mammaglobin-B also known as secretoglobin family 2A member 1 is a protein that in humans is encoded by the SCGB2A1 gene.^[3]^[4]

SCGB2A1 and breast cancer

SCGB2A1 expression is highly specific of mammary tissue, and has been used for identification and detection of disseminated breast cancer cells.^[5]

Related Research Articles

Uteroglobin, or blastokinin, also known as secretoglobin family 1A member 1 (SCGB1A1), is a protein that in humans is encoded by the SCGB1A1 gene.

Secretoglobins (SCGBs) are a family of small, alpha-helical, disulfide linked, dimeric proteins found only in mammals. This family was formerly known as the Uteroglobin/Clara cell 10-kDa family, after the two aliases of its founding member Uteroglobin.

Gamma-synuclein is a protein that in humans is encoded by the SNCG gene.

Receptor-binding cancer antigen expressed on SiSo cells is a protein that in humans is encoded by the EBAG9 gene.

Peroxiredoxin-2 is a protein that in humans is encoded by the PRDX2 gene.

Protein phosphatase 1D is an enzyme that in humans is encoded by the PPM1D gene.

Protein tyrosine phosphatase type IVA 3 is an enzyme that in humans is encoded by the PTP4A3 gene.

Mammaglobin-A also known as secretoglobin family 2A member 2 is a protein that in humans is encoded by the SCGB2A2 gene.

Krueppel-like factor 10 is a protein that in humans is encoded by the KLF10 gene.

Breast cancer metastasis suppressor 1 is a protein that in humans is encoded by the BRMS1 gene.

Nicotinamide N-methyltransferase (NNMT) is an enzyme that in humans is encoded by the NNMT gene. NNMT catalyzes the methylation of nicotinamide and similar compounds using the methyl donor S-adenosyl methionine (SAM-e) to produce S-adenosyl-L-homocysteine (SAH) and 1-methylnicotinamide.

Receptor-type tyrosine-protein phosphatase gamma is an enzyme that in humans is encoded by the PTPRG gene.

60S ribosomal protein L19 is a protein that in humans is encoded by the RPL19 gene.

Cadherin-17 is a protein that in humans is encoded by the CDH17 gene.

Transgelin-2 is a protein that in humans is encoded by the TAGLN2 gene.

Secretoglobin family 3A member 2 is a protein that in humans is encoded by the SCGB3A2 gene.

Mucin-like protein 1 is a protein that in humans is encoded by the MUCL1 gene.

Transmembrane protease, serine 6 is an enzyme that in humans is encoded by the TMPRSS6 gene.

Secretoglobin family 1D member 2 is a protein that in humans is encoded by the SCGB1D2 gene.

Transcription factor AP-2 gamma also known as AP2-gamma is a protein that in humans is encoded by the TFAP2C gene. AP2-gamma is a member of the activating protein 2 family of transcription factors.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000124939 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Becker RM, Darrow C, Zimonjic DB, Popescu NC, Watson MA, Fleming TP (Jan 1999). "Identification of mammaglobin B, a novel member of the uteroglobin gene family". Genomics. 54 (1): 70–8. doi:10.1006/geno.1998.5539. PMID 9806831.
↑ "Entrez Gene: SCGB2A1 secretoglobin, family 2A, member 1".
↑ Lacroix, M (2006). "Significance, detection and markers of disseminated breast cancer cells". Endocrine-Related Cancer . Bioscientifica. 13 (4): 1033–1067. doi: 10.1677/ERC-06-0001 . PMID 17158753.

Molloy MP, Bolis S, Herbert BR, et al. (1998). "Establishment of the human reflex tear two-dimensional polyacrylamide gel electrophoresis reference map: new proteins of potential diagnostic value". Electrophoresis. 18 (15): 2811–5. doi:10.1002/elps.1150181516. PMID 9504814. S2CID 39202047.
Lehrer RI, Xu G, Abduragimov A, et al. (1998). "Lipophilin, a novel heterodimeric protein of human tears". FEBS Lett. 432 (3): 163–7. doi: 10.1016/S0014-5793(98)00852-7 . PMID 9720917. S2CID 205880914.
Zhao C, Nguyen T, Yusifov T, et al. (1999). "Lipophilins: human peptides homologous to rat prostatein". Biochem. Biophys. Res. Commun. 256 (1): 147–55. doi:10.1006/bbrc.1999.0274. PMID 10066439.
Evans V, Vockler C, Friedlander M, et al. (2001). "Lacryglobin in human tears, a potential marker for cancer". Clin. Experiment. Ophthalmol. 29 (3): 161–3. doi:10.1046/j.1442-9071.2001.00408.x. PMID 11446459. S2CID 41723656.
Carter D, Douglass JF, Cornellison CD, et al. (2002). "Purification and characterization of the mammaglobin/lipophilin B complex, a promising diagnostic marker for breast cancer". Biochemistry. 41 (21): 6714–22. doi:10.1021/bi0159884. PMID 12022875.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.
Sjödin A, Guo D, Sørhaug S, et al. (2003). "Dysregulated secretoglobin expression in human lung cancers". Lung Cancer. 41 (1): 49–56. doi:10.1016/S0169-5002(03)00126-0. PMID 12826312.
Ouellette RJ, Richard D, Maïcas E (2004). "RT-PCR for mammaglobin genes, MGB1 and MGB2, identifies breast cancer micrometastases in sentinel lymph nodes". Am. J. Clin. Pathol. 121 (5): 637–43. doi: 10.1309/MMAC-TXT5-5L8Q-TKC1 . PMID 15151203.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Xiao F, Mirwald A, Papaioannou M, et al. (2006). "Secretoglobin 2A1 is under selective androgen control mediated by a peculiar binding site for Sp family transcription factors". Mol. Endocrinol. 19 (12): 2964–78. doi: 10.1210/me.2004-0408 . PMID 16020486.
Bernstein JL, Godbold JH, Raptis G, et al. (2005). "Identification of mammaglobin as a novel serum marker for breast cancer". Clin. Cancer Res. 11 (18): 6528–35. doi: 10.1158/1078-0432.CCR-05-0415 . PMID 16166429.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000124939 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9806831-3] Becker RM, Darrow C, Zimonjic DB, Popescu NC, Watson MA, Fleming TP (Jan 1999). "Identification of mammaglobin B, a novel member of the uteroglobin gene family". Genomics. 54 (1): 70–8. doi:10.1006/geno.1998.5539. PMID 9806831.

[entrez-4] "Entrez Gene: SCGB2A1 secretoglobin, family 2A, member 1".

[Lacroix06-5] Lacroix, M (2006). "Significance, detection and markers of disseminated breast cancer cells". Endocrine-Related Cancer . Bioscientifica. 13 (4): 1033–1067. doi: 10.1677/ERC-06-0001 . PMID 17158753.

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Mammaglobin-B

Contents

SCGB2A1 and breast cancer

Related Research Articles

References

Further reading