Mammaglobin-B

SCGB2A1
Identifiers
Aliases	SCGB2A1 , LPHC, LPNC, MGB2, UGB3, secretoglobin family 2A member 1
External IDs	OMIM: 604398; HomoloGene: 88664; GeneCards: SCGB2A1; OMA:SCGB2A1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q12.3 Start 62,208,673 bp [1] End 62,213,943 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19 A Start 9,847,562 bp [2] End 9,852,808 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis right uterine tube caput epididymis olfactory zone of nasal mucosa beta cell bronchial epithelial cell endometrium nasal epithelium tail of epididymis mucosa of paranasal sinus Top expressed in embryo embryo genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein heterodimerization activity Cellular component extracellular space extracellular region Biological process androgen receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4246 102639117 Ensembl ENSG00000124939 ENSMUSG00000096872 UniProt O75556 J3KMP9 RefSeq (mRNA) NM_002407 XM_006527538 RefSeq (protein) NP_002398 NP_001365339 Location (UCSC) Chr 11: 62.21 – 62.21 Mb Chr 19: 9.85 – 9.85 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mammaglobin-B also known as secretoglobin family 2A member 1 is a protein that in humans is encoded by the SCGB2A1 gene. ^{[5] [6]}

SCGB2A1 and breast cancer

SCGB2A1 expression is highly specific of mammary tissue, and has been used for identification and detection of disseminated breast cancer cells. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000124939 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000096872 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Becker RM, Darrow C, Zimonjic DB, Popescu NC, Watson MA, Fleming TP (Jan 1999). "Identification of mammaglobin B, a novel member of the uteroglobin gene family". Genomics. 54 (1): 70–8. doi:10.1006/geno.1998.5539. PMID   9806831.
6. "Entrez Gene: SCGB2A1 secretoglobin, family 2A, member 1".
7. Lacroix, M (2006). "Significance, detection and markers of disseminated breast cancer cells". Endocrine-Related Cancer . 13 (4). Bioscientifica: 1033–1067. doi: 10.1677/ERC-06-0001 . PMID   17158753.

Further reading

• Molloy MP, Bolis S, Herbert BR, et al. (1998). "Establishment of the human reflex tear two-dimensional polyacrylamide gel electrophoresis reference map: new proteins of potential diagnostic value". Electrophoresis. 18 (15): 2811–5. doi:10.1002/elps.1150181516. PMID   9504814. S2CID   39202047.
• Lehrer RI, Xu G, Abduragimov A, et al. (1998). "Lipophilin, a novel heterodimeric protein of human tears". FEBS Lett. 432 (3): 163–7. Bibcode:1998FEBSL.432..163L. doi: 10.1016/S0014-5793(98)00852-7 . PMID   9720917. S2CID   205880914.
• Zhao C, Nguyen T, Yusifov T, et al. (1999). "Lipophilins: human peptides homologous to rat prostatein". Biochem. Biophys. Res. Commun. 256 (1): 147–55. doi:10.1006/bbrc.1999.0274. PMID   10066439.
• Evans V, Vockler C, Friedlander M, et al. (2001). "Lacryglobin in human tears, a potential marker for cancer". Clin. Experiment. Ophthalmol. 29 (3): 161–3. doi:10.1046/j.1442-9071.2001.00408.x. PMID   11446459. S2CID   41723656.
• Carter D, Douglass JF, Cornellison CD, et al. (2002). "Purification and characterization of the mammaglobin/lipophilin B complex, a promising diagnostic marker for breast cancer". Biochemistry. 41 (21): 6714–22. doi:10.1021/bi0159884. PMID   12022875.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID   12539042. S2CID   26145639.
• Sjödin A, Guo D, Sørhaug S, et al. (2003). "Dysregulated secretoglobin expression in human lung cancers". Lung Cancer. 41 (1): 49–56. doi:10.1016/S0169-5002(03)00126-0. PMID   12826312.
• Ouellette RJ, Richard D, Maïcas E (2004). "RT-PCR for mammaglobin genes, MGB1 and MGB2, identifies breast cancer micrometastases in sentinel lymph nodes". Am. J. Clin. Pathol. 121 (5): 637–43. doi: 10.1309/MMAC-TXT5-5L8Q-TKC1 . PMID   15151203.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Xiao F, Mirwald A, Papaioannou M, et al. (2006). "Secretoglobin 2A1 is under selective androgen control mediated by a peculiar binding site for Sp family transcription factors". Mol. Endocrinol. 19 (12): 2964–78. doi: 10.1210/me.2004-0408 . PMID   16020486.
• Bernstein JL, Godbold JH, Raptis G, et al. (2005). "Identification of mammaglobin as a novel serum marker for breast cancer". Clin. Cancer Res. 11 (18): 6528–35. doi: 10.1158/1078-0432.CCR-05-0415 . PMID   16166429.