Marc E. Rothenberg

Last updated
Marc E. Rothenberg
Born (1961-01-17) January 17, 1961 (age 62) [1]
Forest Hills, NY
EducationBrandeis University; Harvard Medical School
TitleProfessor of Pediatrics;

Director, Division of Allergy and Immunology at Cincinnati Children's Hospital Medical Center;

Director, Cincinnati Center for Eosinophilic Disorders

Contents

Marc E. Rothenberg (born 1961) is an American physician-scientist who has made significant contributions to the fields of allergy, gastroenterology, and immunology. He is currently a Professor of Pediatrics, at Cincinnati Children's Hospital Medical Center, and the University of Cincinnati College of Medicine, the Director of the Division of Allergy and Immunology, the Director of the Cincinnati Center for Eosinophilic Disorders, [2] and the principal investigator of the Consortium of Eosinophilic Disease Researchers (CEGIR) [3] as part of the Rare Disease Clinical Research Network of the National Institute of Health. [4] Rothenberg's research is focused on eosinophilic gastrointestinal diseases. [5]

Early life and education

Rothenberg was born in New York City in 1961. He received his Bachelor of Arts degree in Biochemistry and Chemistry from Brandeis University in 1983. His undergraduate years were influences by the renowned biochemist Professor William P. Jencks, who was Rothenberg’s early research mentor. [6] He went on to earn his medical degree and PhD in Immunology from Harvard Medical School in 1990, conducting research under the mentorship of Professor K. Frank Austen. [6] He completed his residency in pediatrics at Boston Children's Hospital and his fellowship in Allergy and Immunology and Hematology at Boston Children’s Hospital and the Dana Farber Cancer Institute. [2]

Career

Rothenberg began his career as a faculty member at the University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center in 1996, where he has since remained. [2] Rothenberg established the Cincinnati Center for Eosinophilic Disorders, a center focused on eosinophilic diseases. [7]

In 2016, Rothenberg was the first recipient of the Denise and Dave Bunning Chair for Allergy and Immunology. [8]

Rothenberg is also the current Director of the NIH-sponsored Consortium of Eosinophilic Gastrointestinal Disease Researchers, part of the Rare Diseases Clinical Research Network. [3] In 2021, he was elected Co-Chair of the RDCRN. [9]

Research

The Rothenberg CURED Laboratory at Cincinnati Children's Hospital Medical Center conducts research focused on the molecular analysis of allergic inflammation, particularly the pathogenesis of eosinophilic gastrointestinal disorders. [10] His research is credited with elucidating the mechanism of eosinophilia, including the identification of key checkpoints that are central targets for therapeutic intervention. These targets have been translated into developed clinical products. Rothenberg's research has included key proof-of-principle studies that provided the bases for a new class of drugs, anti-eosinophil therapeutics, as well as the first FDA approved drug for eosinophilic esophagitis.

Awards and honors

Rothenberg has been recognized for his contributions to science and medicine with numerous honors and awards, including the American Academy of Allergy, Asthma, and Immunology (AAAAI) Distinguished Scientist Award, [11] the National Institutes of Health (NIH) Merit Award, [12] the E. Mead Johnson Award from the Society of Pediatric Research, [13] and the Paul Ehrlich Award [14] from the International Eosinophil Society. Rothenberg was also recognized as a Highly Cited Researcher in 2018 (Clarivate Analytics). [15] He is an elected member of the American Society for Clinical Investigation, [16] the Association of American Physicians and the National Academy of Medicine. [17] [18] In 2023, Rothenberg was awarded the Daniel Drake Medal for his impact on the field of Allergy and Immunology. [19]

Publications

Rothenberg has authored and co-authored over 500 peer-reviewed articles. [20] [21]

Related Research Articles

<span class="mw-page-title-main">Eosinophil</span> Variety of white blood cells

Eosinophils, sometimes called eosinophiles or, less commonly, acidophils, are a variety of white blood cells and one of the immune system components responsible for combating multicellular parasites and certain infections in vertebrates. Along with mast cells and basophils, they also control mechanisms associated with allergy and asthma. They are granulocytes that develop during hematopoiesis in the bone marrow before migrating into blood, after which they are terminally differentiated and do not multiply. They form about 2 to 3% of white blood cells in the body.

<span class="mw-page-title-main">Eosinophilia</span> Blood condition

Eosinophilia is a condition in which the eosinophil count in the peripheral blood exceeds 5×108/L (500/μL). Hypereosinophilia is an elevation in an individual's circulating blood eosinophil count above 1.5 × 109/L (i.e. 1,500/μL). The hypereosinophilic syndrome is a sustained elevation in this count above 1.5 × 109/L (i.e. 1,500/μL) that is also associated with evidence of eosinophil-based tissue injury.

<span class="mw-page-title-main">Eosinophilic granulomatosis with polyangiitis</span> Medical condition

Eosinophilic granulomatosis with polyangiitis (EGPA), formerly known as allergic granulomatosis, is an extremely rare autoimmune condition that causes inflammation of small and medium-sized blood vessels (vasculitis) in persons with a history of airway allergic hypersensitivity (atopy).

The National Institute of Allergy and Infectious Diseases is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS). NIAID's mission is to conduct basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases.

<span class="mw-page-title-main">Eosinophilic esophagitis</span> Allergic inflammatory condition of the esophagus

Eosinophilic esophagitis (EoE) is an allergic inflammatory condition of the esophagus that involves eosinophils, a type of white blood cell. In healthy individuals, the esophagus is typically devoid of eosinophils. In EoE, eosinophils migrate to the esophagus in large numbers. When a trigger food is eaten, the eosinophils contribute to tissue damage and inflammation. Symptoms include swallowing difficulty, food impaction, vomiting, and heartburn.

<span class="mw-page-title-main">Cincinnati Children's Hospital Medical Center</span> Hospital in Ohio, United States

Cincinnati Children's Hospital Medical Center (CCHMC) is an academic pediatric acute care children's hospital located in the Pill Hill neighborhood of Cincinnati, Ohio. The hospital has 652 pediatric beds and is affiliated with the University of Cincinnati Academic Health Center. The hospital provides comprehensive pediatric specialties and subspecialties to pediatric patients aged 0–21 throughout southern Ohio and northern Kentucky, as well as patients from around the United States and the world. Cincinnati Children's Hospital Medical Center also treats adults, including adults with congenital heart disease and young adults with blood disease or cancer. Cincinnati Children's Hospital Medical Center also features a Level 1 Pediatric Trauma Center, 1 of 4 in the state. Cincinnati Children's is home to a large neonatology department that oversees newborn nurseries at local hospitals around Ohio. The hospital features an AAP verified 59-bed Level IV (highest possible) Newborn Intensive Care Unit.

<span class="mw-page-title-main">Eosinopenia</span> Medical condition

Eosinopenia is a condition where the number of eosinophils, a type of white blood cell, in circulating blood is lower than normal. Eosinophils are a type of granulocyte and consequently from the same cellular lineage as neutrophils, basophils, and mast cells. Along with the other granulocytes, eosinophils are part of the innate immune system and contribute to the defense of the body from pathogens. The most widely understood function of eosinophils is in association with allergy and parasitic disease processes, though their functions in other pathologies are the subject of ongoing research. The opposite phenomenon, in which the number of eosinophils present in the blood is higher than normal, is known as eosinophilia.

Founded in 1943, the American Academy of Allergy, Asthma & Immunology (AAAAI) is a professional medical membership organization of nearly 6,800 allergist/immunologists and related professionals around the world with advanced training and experience in allergy, asthma and other immunologic diseases. The Academy is dedicated to the advancement of the knowledge and practice of allergy, asthma and immunology for optimal patient care.

Mepolizumab, sold under the brand name Nucala by GlaxoSmithKline, is a humanized monoclonal antibody used for the treatment of severe eosinophilic asthma, eosinophilic granulomatosis, and hypereosinophilic syndrome (HES). It recognizes and blocks interleukin-5 (IL-5), a signalling protein of the immune system.

<span class="mw-page-title-main">Eosinophilic gastroenteritis</span> Medical condition

Eosinophilic gastroenteritis is a rare and heterogeneous condition characterized by patchy or diffuse eosinophilic infiltration of gastrointestinal (GI) tissue, first described by Kaijser in 1937. Presentation may vary depending on location as well as depth and extent of bowel wall involvement and usually runs a chronic relapsing course. It can be classified into mucosal, muscular and serosal types based on the depth of involvement. Any part of the GI tract can be affected, and isolated biliary tract involvement has also been reported. The stomach is the organ most commonly affected, followed by the small intestine and the colon.

<span class="mw-page-title-main">Thomas Platts-Mills</span>

Thomas Alexander Evelyn Platts-Mills, FRS son of British member of parliament and barrister John Platts-Mills, is a British allergy researcher and director of the Division of Allergy and Clinical Immunology at the University of Virginia School of Medicine.

An aeroallergen is any airborne substance, such as pollen or spores, which triggers an allergic reaction.

Hans Dieter Ochs, is an immunologist and pediatrician. He is Professor of Pediatrics, Division of Immunology, Department of Pediatrics, University of Washington School of Medicine, Seattle.

The Rare Diseases Clinical Research Network (RDCRN) is an initiative of the US Office of Rare Diseases Research (ORDR). RDCRN is funded by the ORDR, the National Center for Advancing Translational Sciences and collaborating institute centers. The RDCRN is designed to advance medical research on rare diseases by providing support for clinical studies and facilitating collaboration, study enrollment and data sharing. Through the RDCRN consortia, physician scientists and their multidisciplinary teams work together with patient advocacy groups to study more than 200 rare diseases at sites across the nation.

The Rare Diseases Clinical Research Network (RDCRN) Contact Registry is a patient contact registry started in 2004 and sponsored by the National Institutes of Health (NIH). The RDCRN Contact Registry collects and stores the contact information of people who want to participate in RDCRN-sponsored research or learn more about RDCRN research. It connects patients with researchers in order to advance rare disease research.

Eosinophilic myocarditis is inflammation in the heart muscle that is caused by the infiltration and destructive activity of a type of white blood cell, the eosinophil. Typically, the disorder is associated with hypereosinophilia, i.e. an eosinophil blood cell count greater than 1,500 per microliter. It is distinguished from non-eosinophilic myocarditis, which is heart inflammation caused by other types of white blood cells, i.e. lymphocytes and monocytes, as well as the respective descendants of these cells, NK cells and macrophages. This distinction is important because the eosinophil-based disorder is due to a particular set of underlying diseases and its preferred treatments differ from those for non-eosinophilic myocarditis.

Gail Ina Greenberg Shapiro was an American pediatric allergist based in Seattle. She was a faculty member at the University of Washington School of Medicine. In 2001, she became the first democratically elected president of the American Academy of Allergy, Asthma, and Immunology (AAAAI).

Familial eosinophilia is a rare congenital disorder characterized by the presence of sustained elevations in blood eosinophil levels that reach ranges diagnostic of eosinophilia or, far more commonly, hypereosinophilia. Although high eosinophil levels are associated with certain diseases and thought to contribute to the tissue destruction found in many other eosinophilia-related diseases, clinical manifestations and tissue destruction related to the eosinophilia in familial eosinophilia is uncommon: this genetic disease typically has a benign phenotype and course compared to other congenital and acquired eosinophilic diseases.

Mariana Castells is a Spanish-American allergist who focuses on mast cell diseases, including mastocytosis, mast cell activation syndrome and hereditary alpha tryptasimia. Mastocytosis is a rare disease with limited treatment options. Castells works at Brigham and Women's Hospital in Massachusetts in the Department of Allergy, Rheumatology, and Immunology and at the Dana Farber Cancer Institute. She is also a professor of medicine at Harvard Medical School.

Cezmi Akdis is a medical researcher in the field of immunology. He is director of the Swiss Institute of Allergy and Asthma Research (SIAF) in Davos, Switzerland and the editor in chief of the journal Allergy.

References

  1. ↑ "Rothenberg, Marc E., 1961- - LC Linked Data Service: Authorities and Vocabularies | Library of Congress, from LC Linked Data Service: Authorities and Vocabularies (Library of Congress)". Library of Congress. Library of Congress. Retrieved 1 July 2022.
  2. 1 2 3 "Marc E. Rothenberg, MD, PhD". www.cincinnatichildrens.org. Retrieved 2021-12-16.
  3. 1 2 "Scientist Spotlight: Marc Rothenberg Leads Eosinophilic Collaboration and Research to New Discoveries". Rare Diseases Clinical Research Network. Retrieved 2021-12-16.
  4. ↑ "Rare Diseases Clinical Research Network".
  5. ↑ "Rothenberg CURED Lab". Cincinnati Children's Hospital. Retrieved 2021-12-16.
  6. 1 2 "Rothenberg Named to National Academy of Medicine".
  7. ↑ "Eosinophilic Gastrointestinal Disorders | Rothenberg Laboratory Current Projects". www.cincinnatichildrens.org. Retrieved 2021-12-16.
  8. ↑ "Marc Rothenberg Receives First Bunning Chair Cincinnati Children's". www.cincinnatichildrens.org. Retrieved 2021-12-16.
  9. ↑ "RDCRN Announces New 2021 Network Steering Committee Leadership". Rare Diseases Clinical Research Network. Retrieved 2021-12-16.
  10. ↑ "Eosinophilic Gastrointestinal Disorders | Rothenberg Laboratory Current Projects". www.cincinnatichildrens.org. Retrieved 2022-04-30.
  11. ↑ "2023 AAAAI Honorary Award Recipients".
  12. ↑ "Doctor at Cincinnati Children's receives prestigious NIH MERIT Award to extend research of eosinophilic gastrointestinal disorders". www.cincinnatichildrens.org. Retrieved 2021-12-16.
  13. ↑ "Past Award Recipients – Society for Pediatric Research" . Retrieved 2022-04-30.
  14. ↑ "Dr. Rothenberg received the Paul Ehrlich Lectureship Award". Rare Diseases Clinical Research Network. Retrieved 2022-03-31.
  15. ↑ "Clarivate Analytics Highly Cited Researchers 2018-Congratulations to Dr Marc Rothenberg! Edward L. Pratt Research Library". prattlibrary.cchmc.org. Retrieved 2021-12-16.
  16. ↑ "The American Society for Clinical Investigation Directory".
  17. ↑ "About the National Academy of Medicine, Class of 2022".
  18. ↑ "Rothenberg Named to National Academy of Medicine".
  19. ↑ "Four to receive 2023 Daniel Drake Medals from the College of Medicine".
  20. ↑ "My Bibliography - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-04-30.
  21. ↑ "Google Scholar, Marc E. Rothenberg, MD, PhD Profile".
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