Margaret Crane

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Margaret M. Crane
Born1941
NationalityAmerican
Known for Invention of the at-home pregnancy test
Scientific career
FieldsGraphic Design, Product Design
Margaret Crane's patent illustration for "Diagnostic Test Device", the first home pregnancy test Patent for home pregnancy test (US3579306), by Margaret Crane.png
Margaret Crane's patent illustration for "Diagnostic Test Device", the first home pregnancy test

Margaret M. Crane (Meg Crane) is an American inventor and graphic designer who created the first at home pregnancy test in 1967 while working at Organon Pharmaceuticals in West Orange, New Jersey. [1] She is the listed inventor on US Patent 3,579,306 and 215,7774. [2] There was resistance to marketing pregnancy tests for consumers rather than doctors, and the home pregnancy test did not become available until 1977, except for a market test in Canada in 1972. [1]

Contents

She was also a juror in the 2004 trial of Martha Stewart for lying to federal investigators during an insider trading investigation. [3]

Career

At age 26, Crane was hired by Organon in 1967 to work on a new cosmetic line for the company. One day as she was touring the laboratory of the company she noticed many test tubes. Curious to what they were, she asked and to her surprise they were pregnancy tests. Each individual test tube contained reagents that when mixed with a pregnant woman's urine would indicate pregnancy by displaying a red ring at the bottom of the test tube. [4] Inspired by this, Crane saw the possibility of this as a home pregnancy test. She thought it was easy enough to do that women could perform this test at home and in a quicker fashion. Crane had no previous background in science, however, she saw making the pregnancy test an at-home and private experience was important and necessary. This inspired her to create her first model for the test, similar to the tests she observed in her lab. The model Crane proposed was sold across the nation in 1977. Crane and her partner Ira Sturtevant, who aided Crane in her endeavors, went on to develop an advertisement and design firm called Ponzi & Weill. [5]

Invention

Crane took matters into her own hands and went to her home in New York to begin working on her prototype. She combined a paper clip holder, a test tube, a mirror, and a dropper. [4] She put her invention together and presented it to Organon but the idea was at first rejected. Nonetheless, they applied for patents in her name in 1969. [6] When Crane presented her idea, it was met with major pushback. Crane's proposition made the lab hesitant due to worries that the lab would lose business to doctors if women started performing these tests at home. [7] Organon eventually decided to do a test market of the product and Margaret Crane's design was chosen. Organon hired a New York advertising agency to do the marketing, and Ira Sturtevant was to head the account. He took a particular interest in Margret Crane's prototype. He was intrigued by how elegantly the home pregnancy kit was put together. Organon chose Canada for the test market and Crane and Sturtevant were chosen to head the project. They went on to become partners for more than 40 years until his death in 2008. With success the pair went on to build their own marketing company named Ponzi and Weill. [5] This advertising business partnership played an important role in the promotion of the pregnancy test. “Every woman has the right to know whether or not she is pregnant,” said an early ad for the test that women “can do by yourself, at home, in private, in minutes.” [8] This was Margaret Crane's biggest motivator to invent the at home pregnancy kit. Before Crane's invention, women would have to go to a doctor and have their urine tested in a lab to determine if they were pregnant. As a result, women would have to wait weeks for results. In the 1960s, when Crane's idea first came to be, a pregnancy test was processed in a lab by monitoring levels of a hormone called human chorionic gonadotropin (hCG) in urine. [8] It was discovered that women secrete high levels of hCG when pregnant. Therefore, if hCG was detected it indicated pregnancy. Due to the Food and Drug Administration (FDA) rules for medical devices it took a while to receive approval for her prototype in the United States. The pregnancy test developed by Crane did not receive FDA approval until 1976. Soon after, Crane's pregnancy test hit the market in 1977, ten years after she had first proposed her idea. It was marketed as “The Predictor”. [9] Although her name was on the patents for the device, Organon licensed the product to three over-the-counter pharmaceutical companies and Crane never received a penny for her design. She had to sign off her rights for a dollar and never saw that dollar. But she was grateful to have met her partner in the process. It was not until 2012 when the New York Times ran a short "who Made It" feature and Crane received proper recognition for her prototype that simplified the pregnancy of many women. [8] Crane was reading the paper one morning and noticed that the column was about the history of pregnancy test. Her name was not included in the article, and she knew she had to speak up about her contribution in order to receive recognition. Crane was hesitant to come forward because the article was discussing the modern version of the pregnancy test, which Crane did not create. [10] However, since Crane's ideas sparked the change in pregnancy tests with her prototype evolving into what is on shelves today, she stepped forward and emailed the author of the article. Since 2012, Crane has received recognition for her invention.

Legacy

A prototype of The Predictor and a 1970 packaged product version were acquired by the Smithsonian’s National Museum of American History in 2015. [8] [11]

Related Research Articles

<span class="mw-page-title-main">Invention</span> Novel device, material or technical process

An invention is a unique or novel device, method, composition, idea or process. An invention may be an improvement upon a machine, product, or process for increasing efficiency or lowering cost. It may also be an entirely new concept. If an idea is unique enough either as a stand alone invention or as a significant improvement over the work of others, it can be patented. A patent, if granted, gives the inventor a proprietary interest in the patent over a specific period of time, which can be licensed for financial gain.

<span class="mw-page-title-main">Ectopic pregnancy</span> Female reproductive system health issue

Ectopic pregnancy is a complication of pregnancy in which the embryo attaches outside the uterus. Signs and symptoms classically include abdominal pain and vaginal bleeding, but fewer than 50 percent of affected women have both of these symptoms. The pain may be described as sharp, dull, or crampy. Pain may also spread to the shoulder if bleeding into the abdomen has occurred. Severe bleeding may result in a fast heart rate, fainting, or shock. With very rare exceptions, the fetus is unable to survive.

<span class="mw-page-title-main">Human chorionic gonadotropin</span> Hormone

Human chorionic gonadotropin (hCG) is a hormone for the maternal recognition of pregnancy produced by trophoblast cells that are surrounding a growing embryo, which eventually forms the placenta after implantation. The presence of hCG is detected in some pregnancy tests. Some cancerous tumors produce this hormone; therefore, elevated levels measured when the patient is not pregnant may lead to a cancer diagnosis and, if high enough, paraneoplastic syndromes, however, it is not known whether this production is a contributing cause, or an effect of carcinogenesis. The pituitary analog of hCG, known as luteinizing hormone (LH), is produced in the pituitary gland of males and females of all ages.

<span class="mw-page-title-main">Pregnancy test</span> A test based on scientific data to determine if a female is pregnant

A pregnancy test is used to determine whether a female is pregnant or not. The two primary methods are testing for the female pregnancy hormone in blood or urine using a pregnancy test kit, and scanning with ultrasonography. Testing blood for hCG results in the earliest detection of pregnancy. Almost all pregnant women will have a positive urine pregnancy test one week after the first day of a missed menstrual period.

<span class="mw-page-title-main">Margaret E. Knight</span> American inventor (1838–1914)

Margaret Eloise Knight was an American inventor, notably of a machine to produce flat-bottomed paper bags. She has been called "the most famous 19th-century woman inventor". She founded the Eastern Paper Bag Company in 1870, creating paper bags for groceries similar in form to the ones that would be used in later generations. Knight received dozens of patents in different fields, and became a symbol for women's empowerment.

<span class="mw-page-title-main">Prenatal testing</span> Testing for diseases or conditions in a fetus

Prenatal testing consists of prenatal screening and prenatal diagnosis, which are aspects of prenatal care that focus on detecting problems with the pregnancy as early as possible. These may be anatomic and physiologic problems with the health of the zygote, embryo, or fetus, either before gestation even starts or as early in gestation as practicable. Screening can detect problems such as neural tube defects, chromosome abnormalities, and gene mutations that would lead to genetic disorders and birth defects, such as spina bifida, cleft palate, Down syndrome, Tay–Sachs disease, sickle cell anemia, thalassemia, cystic fibrosis, muscular dystrophy, and fragile X syndrome. Some tests are designed to discover problems which primarily affect the health of the mother, such as PAPP-A to detect pre-eclampsia or glucose tolerance tests to diagnose gestational diabetes. Screening can also detect anatomical defects such as hydrocephalus, anencephaly, heart defects, and amniotic band syndrome.

The rabbit test, or Friedman test, was an early pregnancy test developed in 1931 by Maurice Friedman and Maxwell Edward Lapham at the University of Pennsylvania.

The triple test, also called triple screen, the Kettering test or the Bart's test, is an investigation performed during pregnancy in the second trimester to classify a patient as either high-risk or low-risk for chromosomal abnormalities.

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<span class="mw-page-title-main">Pregnancy</span> Time of offspring development in mothers body

Pregnancy is the time during which one or more offspring develops (gestates) inside a woman's uterus (womb). A multiple pregnancy involves more than one offspring, such as with twins.

Unipath Ltd was a pharmaceutical company, subsidiary to Unilever and then Alere, specialising mainly in medical diagnostic kits related to women's reproductive health. It subsequently diversified its product range to include more specialised test kits, primarily for the clinical market, in areas other than women's reproductive healthcare.

Pre-conception counseling is a meeting with a health-care professional by a woman before attempting to become pregnant. It generally includes a pre-conception risk assessment for any potential complications of pregnancy as well as modifications of risk factors, such as increasing folic acid intake to reduce the risk of neural tube defects and counseling on smoking cessation, alcohol reduction, and medications that may compromise fetal development. Physicians, midwives and baby experts recommend that a woman visit them as soon as the woman is contemplating having a child, and optimally around 3 to 6 months before actual attempts are made to conceive. This time frame allows a woman to better prepare her body for successful conception (fertilization) and pregnancy, and allows her to reduce any health risks which are within her control. Agencies such as the March of Dimes have developed screening tools that healthcare providers can use with their patients. In addition, obstetricians or midwives have developed comprehensive check-lists and assessments for the woman who is planning to become pregnant.

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<span class="mw-page-title-main">Fertility testing</span>

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The frog test is a pregnancy testing method relying on frogs to show the pregnancy status of women. Provided that immunological pregnancy tests were not yet developed before 1960s, women living a century ago relied on urine-based pregnancy tests using different animals, ranging from mice to frogs. Nowadays, the advancement in medical technology has enabled women to accurately check their pregnancy status by using 'pee-on-a-stick' pregnancy test kits at home. Before these accessible and convenient test kits were invented, scientists strived to discover a way in spotting pregnancy-related hormones by a natural, simple test, where animals were often included as clinical tools to facilitate the process. The frog test or frog pregnancy test is one of the past prevalent pregnancy scanning methods.

References

  1. 1 2 "Could Women Be Trusted With Their Own Pregnancy Tests?". The New York Times . July 29, 2016.
  2. "Patent US3579306 Diagnostic test device". Google Patents. USPTO and Google. Retrieved August 27, 2014.
  3. Kara Scannell; Matthew Rose; Laurie P. Cohen (March 8, 2004). "In Stewart Case, Reluctant Jurors Found Guilt After Skimpy Defense". The Wall Street Journal.(subscription required)
  4. 1 2 Kennedy, Pagan (July 29, 2016). "Opinion | Could Women Be Trusted With Their Own Pregnancy Tests?". The New York Times. ISSN   0362-4331 . Retrieved May 3, 2019.
  5. 1 2 "Packaging in the news: Meg Crane's Pregnancy Test | BEACH" . Retrieved May 3, 2019.
  6. "Why the Home Pregnancy Test Was Revolutionary". The Atlantic . June 17, 2015.
  7. Faircloth, Kelly (July 29, 2016). "The First At-Home Pregnancy Tests Faced a Big Hurdle: Execs and Regulators Didn't Trust Women". Pictorial. Retrieved May 3, 2019.
  8. 1 2 3 4 Catlin, Roger. "The Unknown Designer of the First Home Pregnancy Test Is Finally Getting Her Due". Smithsonian. Retrieved May 3, 2019.
  9. "Antibodies are a girl's best friend". National Museum of American History. October 6, 2017. Retrieved May 3, 2019.
  10. "In Conversation With: Margaret Crane". Women Across Frontiers Magazine. October 12, 2016. Retrieved May 3, 2019.
  11. "Record Predictor Pregnancy Test | Collections Search Center, Smithsonian Institution". collections.si.edu. Retrieved September 15, 2022.