Margaret McFall-Ngai

Last updated
Margaret McFall-Ngai
Born
Margaret Jean McFall-Ngai
NationalityAmerican
Alma mater University of San Francisco
University of California, Los Angeles
Known for Host-bacterial symbiosis
'Design' of tissues that interact with light
Scientific career
Fields Biology
Institutions University of Hawaiʻi at Mānoa
University of Wisconsin-Madison
University of Southern California
Thesis  (1983)
Doctoral advisor James Morin
Other academic advisorsJoseph Horwitz
George Somero
Website http://glowingsquid.org/

Margaret McFall-Ngai is an American animal physiologist and biochemist [1] best-known for her work related to the symbiotic relationship between Hawaiian bobtail squid, Euprymna scolopes and bioluminescent bacteria, Vibrio fischeri . Her research helped expand the microbiology field, primarily focused on pathogenicity and decomposition at the time, to include positive microbial associations. [2] [3] [4] She currently is a professor at PBRC’s Kewalo Marine Laboratory [5] and director of the Pacific Biosciences Research Program at the University of Hawaiʻi at Mānoa. [6]

Contents

Education and career

McFall-Ngai spent her childhood in Southern California and attended Immaculate Heart High School in Los Angeles. [3] She attended college at the University of San Francisco, graduating in 1973 with a Bachelors of Science in biology. [3] She chose to further her education at the University of California, Los Angeles (UCLA) with doctoral advisor, James Morin, studying functional morphology and comparative physiology [7] while working as a teaching assistant/fellow. [5] Her graduate research took her to the central Philippines to study the relationship between bioluminescent bacteria found in the leiognathid light organ in fish, [8] [9] igniting her “lifelong interest” [3] in the blend of the two subjects. McFall-Ngai graduated with her Ph.D. in Biology in 1983 and went on to complete two postdoctoral fellowships. [6] For her first postdoc, she remained at UCLA working on protein biochemistry-biophysics [7] for the Jules Stein Eye Institute with advisor, Joseph Horwitz. [5] She then moved to San Diego to work with advisor George Somero on protein chemistry enzymology [7] at the Scripps Institute of Oceanography at the University of California, San Diego. [5] On the side McFall-Ngai had been exploring the Hawaiian bobtail squid as an alternative to the fish she had studied in graduate school and initiated what would become a career-long collaboration with microbiologist, Edward (Ned) Ruby, who had written his dissertation on the squids’ symbionts, Vibrio fischeri . [1]

In 1989 McFall-Ngai accepted a position and later received tenure at the University of Southern California in the Department of Biology and began breeding and studying the Hawaiian bobtail squid. [2] She and Ruby moved to Hawaii in 1996 to better study the squid-bacteria relationship, both accepting positions at Pacific Biomedical Research Center at the University of Hawaii. [6] In 2004, McFall-Ngai accepted a position as professor in the Department of Medical Microbiology and Immunology at the University of Wisconsin–Madison and the Eye Research institute. [10] She returned to Hawaii in 2015 when she accepted her current position as director of the Pacific Biosciences Research Program [6] and professor at PBRC’s Kewalo Marine Laboratory at the University of Hawaiʻi at Mānoa. [5]

Research

McFall-Ngai is a pioneer in the study of animal-bacterial symbiosis and known for her research of the Hawaiian bobtail squid, Euprymna scolopes , and its relationship with bacteria, Vibrio fischeri . She initially began her research in graduate school studying fish with a similar bioluminescent bacterial relationship, [8] [9] however, these fish proved difficult to grow in the lab. At a meeting, a visiting researcher from the University of Hawaii suggested she investigate the Hawaiian bobtail squid and its bioluminescent symbionts V. fischeri as an alternative. [1] McFall-Ngai found that the squid worked great in the lab with 8-10 pairs of squid generating roughly 60,000 juveniles a year. [2] To fully study this relationship, McFall-Ngai began collaborating with Edward (Ned) Ruby, a microbiologist who had written his dissertation on V. fischeri. [1]

Over the next three decades, McFall-Ngai, Ruby, and dozens of postdocs and students would investigate all aspects of the symbiotic relationship. [11] They worked to understand the development of the relationship at different stages of the squid life cycle, [12] [13] analyze the initiation of symbiosis in real time, [14] [15] and identify how the host selects its symbionts. [16] [17] [18] They learned that the squid follows a rhythmic pattern in which the bacteria are brightest when the squid hunt at night [19] and are then expelled at dawn. [20] [21] As analysis tools advanced, Ruby and McFall-Ngai were able to map transcriptional patterns and identify related genes that control the squid's rhythmic behaviors and symbiotic relationship. [22] [23] The sum of their Hawaiian bobtail squid research is an extremely well defined model organism fit for studying bacterial symbioses, light interacting tissues, and cephalopod development. [24]

Awards and honors [5]

Society fellowships (elected)

Notable publications

Biographic profiles

Interviews

Related Research Articles

<span class="mw-page-title-main">Endosymbiont</span> Organism that lives within the body or cells of another organism

An endosymbiont or endobiont is any organism that lives within the body or cells of another organism most often, though not always, in a mutualistic relationship. (The term endosymbiosis is from the Greek: ἔνδον endon "within", σύν syn "together" and βίωσις biosis "living".) Examples are nitrogen-fixing bacteria, which live in the root nodules of legumes, single-cell algae inside reef-building corals and bacterial endosymbionts that provide essential nutrients to insects.

<span class="mw-page-title-main">Bioluminescence</span> Emission of light by a living organism

Bioluminescence is the production and emission of light by living organisms. It is a form of chemiluminescence. Bioluminescence occurs widely in marine vertebrates and invertebrates, as well as in some fungi, microorganisms including some bioluminescent bacteria, and terrestrial arthropods such as fireflies. In some animals, the light is bacteriogenic, produced by symbiotic bacteria such as those from the genus Vibrio; in others, it is autogenic, produced by the animals themselves.

<i>Vibrio</i> Genus of bacteria

Vibrio is a genus of Gram-negative bacteria, possessing a curved-rod (comma) shape, several species of which can cause foodborne infection, usually associated with eating undercooked seafood. Being highly salt tolerant and unable to survive in fresh water, Vibrio spp. are commonly found in various salt water environments. Vibrio spp. are facultative anaerobes that test positive for oxidase and do not form spores. All members of the genus are motile. They are able to have polar or lateral flagellum with or without sheaths. Vibrio species typically possess two chromosomes, which is unusual for bacteria. Each chromosome has a distinct and independent origin of replication, and are conserved together over time in the genus. Recent phylogenies have been constructed based on a suite of genes.

<span class="mw-page-title-main">Bobtail squid</span> Order cephalopod molluscs closely related to cuttlefish

Bobtail squid are a group of cephalopods closely related to cuttlefish. Bobtail squid tend to have a rounder mantle than cuttlefish and have no cuttlebone. They have eight suckered arms and two tentacles and are generally quite small.

<i>Aliivibrio fischeri</i> Species of bacterium

Aliivibrio fischeri is a Gram-negative, rod-shaped bacterium found globally in marine environments. This species has bioluminescent properties, and is found predominantly in symbiosis with various marine animals, such as the Hawaiian bobtail squid. It is heterotrophic, oxidase-positive, and motile by means of a single polar flagella. Free-living A. fischeri cells survive on decaying organic matter. The bacterium is a key research organism for examination of microbial bioluminescence, quorum sensing, and bacterial-animal symbiosis. It is named after Bernhard Fischer, a German microbiologist.

<span class="mw-page-title-main">Vibrionaceae</span> Family of bacteria

The Vibrionaceae are a family of Pseudomonadota given their own order, Vibrionales. Inhabitants of fresh or salt water, several species are pathogenic, including the type species Vibrio cholerae, which is the agent responsible for cholera. Most bioluminescent bacteria belong to this family, and are typically found as symbionts of deep-sea animals.

<span class="mw-page-title-main">Aposymbiosis</span>

Aposymbiosis occurs when symbiotic organisms live apart from one another. Studies have shown that the lifecycles of both the host and the symbiont are affected in some way, usually negative, and that for obligate symbiosis the effects can be drastic. Aposymbiosis is distinct from exsymbiosis, which occurs when organisms are recently separated from a symbiotic association. Because symbionts can be vertically transmitted from parent to offspring or horizontally transmitted from the environment, the presence of an aposymbiotic state suggests that transmission of the symbiont is horizontal. A classical example of a symbiotic relationship with an aposymbiotic state is the Hawaiian bobtail squid Euprymna scolopes and the bioluminescent bacteria Vibrio fischeri. While the nocturnal squid hunts, the bacteria emit light of similar intensity of the moon which camouflages the squid from predators. Juveniles are colonized within hours of hatching and Vibrio must outcompete other bacteria in the seawater through a system of recognition and infection.

<i>Euprymna scolopes</i> Species of cephalopods known as the Hawaiian bobtail squid

Euprymna scolopes, also known as the Hawaiian bobtail squid, is a species of bobtail squid in the family Sepiolidae native to the central Pacific Ocean, where it occurs in shallow coastal waters off the Hawaiian Islands and Midway Island. The type specimen was collected off the Hawaiian Islands and is deposited at the National Museum of Natural History in Washington, D.C.

Autoinducers are signaling molecules that are produced in response to changes in cell-population density. As the density of quorum sensing bacterial cells increases so does the concentration of the autoinducer. Detection of signal molecules by bacteria acts as stimulation which leads to altered gene expression once the minimal threshold is reached. Quorum sensing is a phenomenon that allows both Gram-negative and Gram-positive bacteria to sense one another and to regulate a wide variety of physiological activities. Such activities include symbiosis, virulence, motility, antibiotic production, and biofilm formation. Autoinducers come in a number of different forms depending on the species, but the effect that they have is similar in many cases. Autoinducers allow bacteria to communicate both within and between different species. This communication alters gene expression and allows bacteria to mount coordinated responses to their environments, in a manner that is comparable to behavior and signaling in higher organisms. Not surprisingly, it has been suggested that quorum sensing may have been an important evolutionary milestone that ultimately gave rise to multicellular life forms.

<span class="mw-page-title-main">Counter-illumination</span> Active camouflage using light matched to the background

Counter-illumination is a method of active camouflage seen in marine animals such as firefly squid and midshipman fish, and in military prototypes, producing light to match their backgrounds in both brightness and wavelength.

The hologenome theory of evolution recasts the individual animal or plant as a community or a "holobiont" – the host plus all of its symbiotic microbes. Consequently, the collective genomes of the holobiont form a "hologenome". Holobionts and hologenomes are structural entities that replace misnomers in the context of host-microbiota symbioses such as superorganism, organ, and metagenome. Variation in the hologenome may encode phenotypic plasticity of the holobiont and can be subject to evolutionary changes caused by selection and drift, if portions of the hologenome are transmitted between generations with reasonable fidelity. One of the important outcomes of recasting the individual as a holobiont subject to evolutionary forces is that genetic variation in the hologenome can be brought about by changes in the host genome and also by changes in the microbiome, including new acquisitions of microbes, horizontal gene transfers, and changes in microbial abundance within hosts. Although there is a rich literature on binary host–microbe symbioses, the hologenome concept distinguishes itself by including the vast symbiotic complexity inherent in many multicellular hosts. For recent literature on holobionts and hologenomes published in an open access platform, see the following reference.

<span class="mw-page-title-main">Tracheal cytotoxin</span> Chemical compound

Tracheal cytotoxin (TCT) is a 921 dalton glycopeptide released by Bordetella pertussis, Vibrio fischeri, and Neisseria gonorrhoeae. It is a soluble piece of peptidoglycan (PGN) found in the cell wall of all gram-negative bacteria, but only some bacteria species release TCT due to inability to recycle this piece of anhydromuropeptide.

<span class="mw-page-title-main">Bioluminescent bacteria</span>

Bioluminescent bacteria are light-producing bacteria that are predominantly present in sea water, marine sediments, the surface of decomposing fish and in the gut of marine animals. While not as common, bacterial bioluminescence is also found in terrestrial and freshwater bacteria. These bacteria may be free living or in symbiosis with animals such as the Hawaiian Bobtail squid or terrestrial nematodes. The host organisms provide these bacteria a safe home and sufficient nutrition. In exchange, the hosts use the light produced by the bacteria for camouflage, prey and/or mate attraction. Bioluminescent bacteria have evolved symbiotic relationships with other organisms in which both participants benefit close to equally. Another possible reason bacteria use luminescence reaction is for quorum sensing, an ability to regulate gene expression in response to bacterial cell density.

<span class="mw-page-title-main">Marine microbial symbiosis</span>

Microbial symbiosis in marine animals was not discovered until 1981. In the time following, symbiotic relationships between marine invertebrates and chemoautotrophic bacteria have been found in a variety of ecosystems, ranging from shallow coastal waters to deep-sea hydrothermal vents. Symbiosis is a way for marine organisms to find creative ways to survive in a very dynamic environment. They are different in relation to how dependent the organisms are on each other or how they are associated. It is also considered a selective force behind evolution in some scientific aspects. The symbiotic relationships of organisms has the ability to change behavior, morphology and metabolic pathways. With increased recognition and research, new terminology also arises, such as holobiont, which the relationship between a host and its symbionts as one grouping. Many scientists will look at the hologenome, which is the combined genetic information of the host and its symbionts. These terms are more commonly used to describe microbial symbionts.

Nicole Dubilier is a marine microbiologist and director of the Symbiosis Department at the Max Planck Institute for Marine Microbiology since 2013 and a Professor of Microbial Symbioses at the University of Bremen. She is a pioneer in ecological and evolutionary symbiotic relationships between sea animals and their microbial partners inhabiting environments that harbour low nutrient concentrations. She was responsible for the discovery of a new form of symbiosis between two kinds of bacteria and the marine oligochaete Olavius algarvensis.

Karen Visick, Ph.D. is an American microbiologist and expert in bacterial genetics known for her work on the role of bacteria to form biofilm communities during animal colonization. She conducted doctoral research with geneticist Kelly Hughes at the University of Washington, where she identified a key regulatory checkpoint during construction of the bacterial flagellum. She conducted postdoctoral research on development of the Vibrio fischeri-Euprymna scolopes symbiosis with Ned Ruby at University of Southern California and University of Hawaiʻi. The bacteria are bioluminescent and provide light to the host. Visick and Ruby revealed that bacteria that do not produce light exhibit a defect during host colonization.

<span class="mw-page-title-main">Marine microbiome</span>

All animals on Earth form associations with microorganisms, including protists, bacteria, archaea, fungi, and viruses. In the ocean, animal–microbial relationships were historically explored in single host–symbiont systems. However, new explorations into the diversity of marine microorganisms associating with diverse marine animal hosts is moving the field into studies that address interactions between the animal host and a more multi-member microbiome. The potential for microbiomes to influence the health, physiology, behavior, and ecology of marine animals could alter current understandings of how marine animals adapt to change, and especially the growing climate-related and anthropogenic-induced changes already impacting the ocean environment.

<span class="mw-page-title-main">Marine prokaryotes</span> Marine bacteria and marine archaea

Marine prokaryotes are marine bacteria and marine archaea. They are defined by their habitat as prokaryotes that live in marine environments, that is, in the saltwater of seas or oceans or the brackish water of coastal estuaries. All cellular life forms can be divided into prokaryotes and eukaryotes. Eukaryotes are organisms whose cells have a nucleus enclosed within membranes, whereas prokaryotes are the organisms that do not have a nucleus enclosed within a membrane. The three-domain system of classifying life adds another division: the prokaryotes are divided into two domains of life, the microscopic bacteria and the microscopic archaea, while everything else, the eukaryotes, become the third domain.

Ecological evolutionary developmental biology (eco-evo-devo) is a field of biology combining ecology, developmental biology and evolutionary biology to examine their relationship. The concept is closely tied to multiple biological mechanisms. The effects of eco-evo-devo can be a result of developmental plasticity, the result of symbiotic relationships or epigenetically inherited. The overlap between developmental plasticity and symbioses rooted in evolutionary concepts defines ecological evolutionary developmental biology. Host- microorganisms interactions during development characterize symbiotic relationships, whilst the spectrum of phenotypes rooted in canalization with response to environmental cues highlights plasticity. Developmental plasticity that is controlled by environmental temperature may put certain species at risk as a result of climate change.

<span class="mw-page-title-main">Jamie S. Foster</span> American astrobiologist, microbiologist, and academic

Jamie S. Foster is an American astrobiologist, microbiologist, and academic. She is a professor at the Department of Microbiology and Cell Science, and Genetics and Genomes Graduate Program at the University of Florida.

References

  1. 1 2 3 4 "Hawaiian Bobtail Squid: Using Light to Hide in the Dark—Dr. Margaret Mc-Fall Ngai—The Squid Vibrio Labs". FutureTech Podcast. 2019-09-23. Retrieved 1 December 2019.
  2. 1 2 3 Yong, E (15 January 2015). "Microbiology: Here's looking at you, squid". Nature. 517 (7534): 262–4. Bibcode:2015Natur.517..262Y. doi: 10.1038/517262a . PMID   25592518.
  3. 1 2 3 4 Viegas, Jennifer (2017-08-22). "Profile of Margaret J. McFall-Ngai". Proceedings of the National Academy of Sciences. 114 (36): 9494–9496. doi: 10.1073/pnas.1713158114 . ISSN   0027-8424. PMC   5594705 . PMID   28830998.
  4. ↑ "Margaret McFall-Ngai". John Simon Guggenheim Memorial Foundation. Archived from the original on 28 August 2018. Retrieved 2 December 2019.
  5. 1 2 3 4 5 6 McFall-Ngai, Margaret. "McFall-Ngai CV" (PDF). Retrieved 1 December 2019.
  6. 1 2 3 4 McFall-Ngai, Margaret. "Margaret McFall-Ngai, PH.D". Pacific Biosciences Research Center. Pacific Biosciences Research Center, University of Hawai‘i at Mānoa. Retrieved 1 December 2019.
  7. 1 2 3 Amato, Katherine. "Q&A With Margaret McFall-Ngai".
  8. 1 2 McFall-Ngai, Margaret (April 1983). "Three new modes of luminescence in the leiognathid fish Gazza minuta: Discrete projected luminescence, ventral body flash, and buccal luminescence". Marine Biology. 73 (3): 227–237. doi:10.1007/BF00392247. S2CID   84813290.
  9. 1 2 McFall-Ngai, Margaret (July 1983). "Adaptations for reflection of bioluminescent light in the gas bladder of Leiognathus equulus (Perciformes: Leiognathidae)". Journal of Experimental Zoology. 227 (1): 23–33. doi:10.1002/jez.1402270105. PMID   6619765.
  10. ↑ "Margaret J. McFall-Ngai, PH.D". McPherson Eye Research Institute. 10 August 2017. Retrieved 2 December 2019.
  11. ↑ McFall-Ngai, M (February 2014). "Divining the essence of symbiosis: insights from the squid-vibrio model". PLOS Biology. 12 (2): e1001783. doi:10.1371/journal.pbio.1001783. PMC   3913551 . PMID   24504482.
  12. ↑ Montgomery, MK; McFall-Ngai, M (June 1993). "Embryonic Development of the Light Organ of the Sepiolid Squid Euprymna scolopes Berry". The Biological Bulletin. 184 (3): 296–308. doi:10.2307/1542448. JSTOR   1542448. PMID   29300543.
  13. ↑ Montgomery, MK; McFall-Ngai, M (July 1994). "Bacterial symbionts induce host organ morphogenesis during early postembryonic development of the squid Euprymna scolopes". Development. 120 (7): 1719–29. doi:10.1242/dev.120.7.1719. PMID   7924980.
  14. ↑ Nyholm, SV; Stabb, EV; Ruby, EG; McFall-Ngai, MJ (29 August 2000). "Establishment of an animal-bacterial association: recruiting symbiotic vibrios from the environment". Proceedings of the National Academy of Sciences of the United States of America. 97 (18): 10231–5. doi: 10.1073/pnas.97.18.10231 . PMC   27829 . PMID   10963683.
  15. ↑ Foster, JS; McFall-Ngai, MJ (August 1998). "Induction of apoptosis by cooperative bacteria in the morphogenesis of host epithelial tissues". Development Genes and Evolution. 208 (6): 295–303. doi:10.1007/s004270050185. PMID   9716720. S2CID   24818919.
  16. ↑ Altura, MA; Heath-Heckman, EA; Gillette, A; Kremer, N; Krachler, AM; Brennan, C; Ruby, EG; Orth, K; McFall-Ngai, MJ (November 2013). "The first engagement of partners in the Euprymna scolopes-Vibrio fischeri symbiosis is a two-step process initiated by a few environmental symbiont cells". Environmental Microbiology. 15 (11): 2937–50. doi:10.1111/1462-2920.12179. PMC   3937295 . PMID   23819708.
  17. ↑ Visick, KL (November 2009). "An intricate network of regulators controls biofilm formation and colonization by Vibrio fischeri". Molecular Microbiology. 74 (4): 782–9. doi:10.1111/j.1365-2958.2009.06899.x. PMC   2906375 . PMID   19818022.
  18. ↑ Wollenberg, MS; Ruby, EG (January 2009). "Population structure of Vibrio fischeri within the light organs of Euprymna scolopes squid from Two Oahu (Hawaii) populations". Applied and Environmental Microbiology. 75 (1): 193–202. doi:10.1128/AEM.01792-08. PMC   2612210 . PMID   18997024.
  19. ↑ Boettcher, K.J.; Ruby, E.G.; McFall-Ngai, M.J. (July 1996). "Bioluminescence in the symbiotic squid Euprymna scolopes is controlled by a daily biological rhythm". Journal of Comparative Physiology A. 179 (1). doi:10.1007/BF00193435. S2CID   28096354.
  20. ↑ Graf, J; Ruby, EG (17 February 1998). "Host-derived amino acids support the proliferation of symbiotic bacteria". Proceedings of the National Academy of Sciences of the United States of America. 95 (4): 1818–22. Bibcode:1998PNAS...95.1818G. doi: 10.1073/pnas.95.4.1818 . PMC   19196 . PMID   9465100.
  21. ↑ Heath-Heckman, Elizabeth A. C.; Peyer, Suzanne M.; Whistler, Cheryl A.; Apicella, Michael A.; Goldman, William E.; McFall-Ngai, Margaret J.; Handelsman, Jo (2 April 2013). "Bacterial Bioluminescence Regulates Expression of a Host Cryptochrome Gene in the Squid-Vibrio Symbiosis". mBio. 4 (2). doi:10.1128/mBio.00167-13. PMC   3622930 . PMID   23549919.
  22. ↑ Wier, AM; Nyholm, SV; Mandel, MJ; Massengo-Tiassé, RP; Schaefer, AL; Koroleva, I; Splinter-Bondurant, S; Brown, B; Manzella, L; Snir, E; Almabrazi, H; Scheetz, TE; Bonaldo Mde, F; Casavant, TL; Soares, MB; Cronan, JE; Reed, JL; Ruby, EG; McFall-Ngai, MJ (2 February 2010). "Transcriptional patterns in both host and bacterium underlie a daily rhythm of anatomical and metabolic change in a beneficial symbiosis". Proceedings of the National Academy of Sciences of the United States of America. 107 (5): 2259–64. Bibcode:2010PNAS..107.2259W. doi: 10.1073/pnas.0909712107 . PMC   2836665 . PMID   20133870.
  23. ↑ Kremer, N; Philipp, EE; Carpentier, MC; Brennan, CA; Kraemer, L; Altura, MA; Augustin, R; Häsler, R; Heath-Heckman, EA; Peyer, SM; Schwartzman, J; Rader, BA; Ruby, EG; Rosenstiel, P; McFall-Ngai, MJ (14 August 2013). "Initial symbiont contact orchestrates host-organ-wide transcriptional changes that prime tissue colonization". Cell Host & Microbe. 14 (2): 183–94. doi:10.1016/j.chom.2013.07.006. PMC   3928804 . PMID   23954157.
  24. ↑ Lee, PN; McFall-Ngai, MJ; Callaerts, P; de Couet, HG (November 2009). "The Hawaiian bobtail squid (Euprymna scolopes): a model to study the molecular basis of eukaryote-prokaryote mutualism and the development and evolution of morphological novelties in cephalopods". Cold Spring Harbor Protocols. 2009 (11): pdb.emo135. doi:10.1101/pdb.emo135. PMID   20150047.
  25. 1 2 "Margaret McFall-Ngai". The Squid Vibrio Labs. Retrieved 5 December 2019.
  26. ↑ "News 2019". The Squid Vibrio Labs. Retrieved 5 December 2019.
  27. ↑ McFall-Ngai, Margaret (January 2007). "Care for the community". Nature. 445 (7124): 153. Bibcode:2007Natur.445..153M. doi:10.1038/445153a. ISSN   0028-0836. PMID   17215830. S2CID   9273396.
  28. ↑ McFall-Ngai, Margaret; Hadfield, Michael G.; Bosch, Thomas C. G.; Carey, Hannah V.; Domazet-Lošo, Tomislav; Douglas, Angela E.; Dubilier, Nicole; Eberl, Gerard; Fukami, Tadashi (2013-02-26). "Animals in a bacterial world, a new imperative for the life sciences". Proceedings of the National Academy of Sciences. 110 (9): 3229–3236. Bibcode:2013PNAS..110.3229M. doi: 10.1073/pnas.1218525110 . ISSN   0027-8424. PMC   3587249 . PMID   23391737.
  29. ↑ Nyholm, Spencer V.; McFall-Ngai, Margaret (August 2004). "The winnowing: establishing the squid–vibrio symbiosis". Nature Reviews Microbiology. 2 (8): 632–642. doi:10.1038/nrmicro957. ISSN   1740-1526. PMID   15263898. S2CID   21583331.
  30. ↑ McFall-Ngai, Margaret J. (2002-02-01). "Unseen Forces: The Influence of Bacteria on Animal Development". Developmental Biology. 242 (1): 1–14. doi: 10.1006/dbio.2001.0522 . ISSN   0012-1606. PMID   11795936.
  31. ↑ Montgomery, M. K.; McFall-Ngai, M. (1994-07-01). "Bacterial symbionts induce host organ morphogenesis during early postembryonic development of the squid Euprymna scolopes". Development. 120 (7): 1719–1729. doi:10.1242/dev.120.7.1719. ISSN   0950-1991. PMID   7924980. Archived from the original on 2017-08-20. Retrieved 2018-10-17.
  32. ↑ Crookes, Wendy J.; Ding, Lin-Lin; Huang, Qing Ling; Kimbell, Jennifer R.; Horwitz, Joseph; McFall-Ngai, Margaret J. (2004-01-09). "Reflectins: The Unusual Proteins of Squid Reflective Tissues". Science. 303 (5655): 235–238. Bibcode:2004Sci...303..235C. doi:10.1126/science.1091288. ISSN   0036-8075. PMID   14716016. S2CID   44490101.
  33. ↑ Visick, K. L.; Foster, J.; Doino, J.; McFall-Ngai, M.; Ruby, E. G. (August 2000). "Vibrio fischeri lux genes play an important role in colonization and development of the host light organ". Journal of Bacteriology. 182 (16): 4578–4586. doi:10.1128/JB.182.16.4578-4586.2000. ISSN   0021-9193. PMC   94630 . PMID   10913092.
  34. ↑ Yong, Ed (14 January 2015). "Here's looking at you, squid". Nature. 517 (7534): 262–264. Bibcode:2015Natur.517..262Y. doi: 10.1038/517262a . PMID   25592518.
  35. ↑ Viegas, Jennifer (5 September 2017). "Profile of Margaret J. McFall-Ngai". Proceedings of the National Academy of Sciences USA. 114 (36): 9494–9496. doi: 10.1073/pnas.1713158114 . PMC   5594705 . PMID   28830998.
  36. ↑ Yong, Ed (2016). I contain multitudes: the microbes within us and a grander view of life. Random House. ISBN   9780062368591.
  37. ↑ Brown, Brandon (2012-07-07). "The Extra Pounds You Can't Afford to Lose: An Interview With Microbiologist Margaret McFall-Ngai". HuffPost. Retrieved 5 December 2019.
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