Marion Jean Lewis OC OM FRSC (born 1925 in Windsor, Ontario) is a Canadian medical researcher, known for her work on the Rh factor [1] [2] and on the Duffy antigen system. [3]
Lewis graduated from Winnipeg's Gordon Bell High School in 1943. She was trained as a medical technician at Winnipeg General Hospital. In 1944, the pediatric pathologist Bruce Chown, assisted by Lewis, opened the Rh Laboratory in Winnipeg to study and eradicate Rh disease. [2] [1] Their research led to effective treatments and a vaccine that prevents Rh disease. [4] [5]
In 1950–51, Lewis spent four months at an Italian university studying the Italian language and culture. She then spent another three months studying in London under world-renowned ‘blood groupers’ Robert Race and Ruth Sanger. In 1951, she returned to Winnipeg and the Rh lab. [1] From 1952 and 1960, Chown and Lewis made annual trips, visiting Canadian tribal groups, including the Blackfoot and Cree, to test their blood for Rh factors. They also tested Inuit at Kugluktuk and Southampton Island and Hutterites in Manitoba. [1]
While Chown retired in 1977, Lewis continued on in the field of blood group gene mapping and eventually branched out into the field of genetics. She and her colleagues at the Rh Laboratory, including Hiroko Kaita, became internationally renowned for their work. [1]
In the Department of Pediatrics at the University of Manitoba's the Faculty of Medicine, Lewis was an assistant professor from 1973 to 1977, an associate professor from 1977 to 1984, and a full professor from 1984 to 1996, when she retired as professor emerita. [1] She is the author or co-author of more than 140 articles. [4]
On 27 June 2019, Lewis was appointed as an Officer to the Order of Canada for her contributions to the prevention and treatment of Rh disease. [6] [7] In 2020, Lewis was appointed as a member of the Order of Manitoba. [8]
The University of Manitoba is a Canadian public research university in the province of Manitoba. Founded in 1877, it is the first university of western Canada.
A blood type is a classification of blood, based on the presence and absence of antibodies and inherited antigenic substances on the surface of red blood cells (RBCs). These antigens may be proteins, carbohydrates, glycoproteins, or glycolipids, depending on the blood group system. Some of these antigens are also present on the surface of other types of cells of various tissues. Several of these red blood cell surface antigens can stem from one allele and collectively form a blood group system.
Rh disease is a type of hemolytic disease of the fetus and newborn (HDFN). HDFN due to anti-D antibodies is the proper and currently used name for this disease as the Rh blood group system actually has more than 50 antigens and not only the D-antigen. The term "Rh Disease" is commonly used to refer to HDFN due to anti-D antibodies, and prior to the discovery of anti-Rho(D) immune globulin, it was the most common type of HDFN. The disease ranges from mild to severe, and occurs in the second or subsequent pregnancies of Rh-D negative women when the biologic father is Rh-D positive.
Sir Cyril Astley Clarke, KBE, FRCP, FRCOG, (Hon) FRC Path, FRS was a British physician, geneticist and lepidopterist. He was honoured for his pioneering work on prevention of Rh disease of the newborn, and also for his work on the genetics of the Lepidoptera.
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William Boyd, FRCPath, was a Scottish-Canadian physician, pathologist, academic, and author known for his medical textbooks.
Bruce Chown was a Canadian medical doctor who researched the blood factor known as the Rhesus factor and discovered an Rh immune vaccine, Rh gamma globulin, which helps to prevent Erythroblastosis fetalis.
The Health Sciences Centre (HSC), located in Winnipeg, is the largest health-care facility in Manitoba and one of the largest hospitals in Canada. It serves the residents of Manitoba, Northwestern Ontario, and Nunavut as both a teaching hospital and as a research centre. HSC is a tertiary care hospital, encompassing many different specialty medical and surgical services. The Health Sciences Centre employs around 8,000 people. A few other health-related institutions are located adjacent to the hospital.
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John Maxwell "Jack" Bowman was a Canadian pediatrician, medical researcher, and professor of medicine. He was an internationally recognized expert in the treatment and prevention of Rh disease in newborns.
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Isabel George Auld was the chancellor of the University of Manitoba from 1977 to 1986. Before becoming the first woman to hold this position, Auld primarily worked as a volunteer from the 1940s to 1960s. During this time period, she co-founded the Consumers' Association of Canada in 1953 and became the association's president in 1964. Leading up to 1977, Auld was part of the board of directors for Manitoba and the admissions committee for the university's dentistry department. Following her career, Auld became a Member of the Order of Canada in 1989. She also received the Queen Elizabeth II Golden Jubilee Medal in 2002 and the Queen Elizabeth II Diamond Jubilee Medal in 2012.
Xiangguo Qiu is a Chinese Canadian virologist, former adjunct professor of Medical microbiology at the University of Manitoba and former head of the Vaccine Development and Antiviral Therapies section in the Special Pathogen Program of the Public Health Agency of Canada (PHAC). She is credited as one of the researchers who helped cure Ebola.