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Mark Andrew Estelle is a Canadian-American biologist known for his work elucidating the mechanism of the plant hormone, auxin using the model plant Arabidopsis thaliana . He is currently a Distinguished Professor at University of California San Diego.
Mark Andrew Estelle was born in Calgary Alberta, Canada in 1955.[ citation needed ] His undergraduate and graduate education emphasized genetic approaches to problems, regardless of species or organism which helped him develop a broad view of approaching scientific investigation. [1]
Mark earned his BS. degree at University of Alberta B.S. in 1978. [2] He earned his Ph.D. in genetics from the University of Alberta in 1983. [2] His doctoral research involved the fruit fly and was entitled "The analysis of a dopa decarboxylase activity variant in Drosophila melanogaster". [3]
Mark Estelle continued his scientific training as a research associate of the Michigan State University-U.S. Department of Energy Plant Research Laboratory with Dr. Chris R. Somerville (1983–86). [2] [4]
In 1986, he was hired as an Assistant Professor at Indiana University and eventually became the Indiana University Miller Chair in Plant Developmental Biology 2002-2008. [2] [5] He later moved his research lab to the University of California San Diego as a Distinguished Professor, Department of Cellular and Developmental Biology 2008–present. [6]
Estelle's laboratory utilizes the plant Arabidopsis thaliana to identify auxin response pathways. His group determined that auxin response depends on the degradation of transcriptional repressors called the Aux/IAA proteins with requires the ubiquitin protein ligase E3 called SCFTIR1. [7]
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