MSU-DOE Plant Research Laboratory

Last updated
MSU-DOE Plant Research Laboratory
PRL
Motto Plant science driving innovation
Established1965
Research typeBasic research on photosynthetic organisms; real-world applications
Budget $10 mil (research grants)
Field of research
Director Christoph Benning
Staff 150
Location East Lansing, Michigan, United States
42°43′22″N84°28′26″W / 42.72278°N 84.47389°W / 42.72278; -84.47389
Affiliations
Website www.prl.msu.edu

The MSU-DOE Plant Research Laboratory (PRL), commonly referred to as Plant Research Lab, is a research institute funded to a large extent by the U.S. Department of Energy Office of Science and located at Michigan State University (MSU) in East Lansing, Michigan. The Plant Research Lab was founded in 1965, and it currently includes twelve laboratories that conduct collaborative basic research into the biology of diverse photosynthetic organisms, including plants, bacteria, and algae, in addition to developing new technologies towards addressing energy and food challenges.

Contents

History

1964-1978

The contract for the establishment of the MSU-DOE Plant Research Laboratory was signed on March 6, 1964, between the U.S. Atomic Energy Commission (AEC) and Michigan State University. [1] :6 The institute was initially funded by the AEC's Division of Biology and Medicine, which saw a need for improving the state of plant sciences in the United States. The Division aimed to create a new program at one or more universities where student interest in plant research could be fostered. [2] :37

The contract signed between AEC and Michigan State University provided for a comprehensive research program in plant biology and related education and training at the graduate and postgraduate levels. The program was to draw strongly on related disciplines such as biochemistry, biophysics, genetics, microbiology, and others.

In 1966, personnel of the new program - called MSU-AEC Plant Research Laboratory at that time - moved into their new quarters in the Plant Biology Laboratories building at Michigan State University. The first research projects generally focused on problems specific to plants, such as cell growth and its regulation by plant hormones, cell wall structure and composition, and the physiology of flower formation; other research projects addressed general biological problems, such as the regulation of enzyme formation during development and cellular and genetic aspects of hormone action.

In the 1970s, federal funding of the Plant Research Lab changed hands a number of times. The AEC was abolished following the Energy Reorganization Act of 1974, and its functions were assigned to two new agencies. In 1975, the Plant Research Lab thus found itself supported by the newly formed Energy Research and Development Administration, which in turn, was consolidated into the U.S. Department of Energy (DOE) in 1978. [3] [4] The institute's name was modified in step with the changes at the federal level, finally settling on its current name, MSU-DOE Plant Research Laboratory.

Christoph Benning, the current PRL director, with two past directors, Michael Thomashow and Kenneth Keegstra, at the 50th PRL anniversary celebration in 2014. CB with MT and KK.jpg
Christoph Benning, the current PRL director, with two past directors, Michael Thomashow and Kenneth Keegstra, at the 50th PRL anniversary celebration in 2014.

1978-2006

The DOE broadened the laboratory's mandate to look at basic plant processes, especially regarding the growth of plants as a renewable resource, with the focus of research shifting to modern plant molecular biology. During that period, Plant Research Lab scientists were among the pioneers who introduced the use of the model plant, Arabidopsis thaliana , into plant biology. [5] [6]

Starting in the 1990s, the Plant Research Lab initiated a culture of group projects, which combined the talents of Plant Research Lab faculty members with scientists from other departments at Michigan State University, in order to tackle difficult and risky research projects. Projects included the biosynthesis of cell wall components, [7] establishing a genetic system for the nitrogen-fixing actinomycete Frankia, [8] studying the molecular basis of flower induction, [9] studying membrane-tethered transcription factors, [10] and others.

Pamela Green, Shauna Somerville, and Natasha Raikhel at the 50th PRL anniversary celebration in 2014. Pamela Green, Shauna Somerville, and Natasha Raikhel.jpg
Pamela Green, Shauna Somerville, and Natasha Raikhel at the 50th PRL anniversary celebration in 2014.

2006-present

In 2006, the Plant Research Lab's research mission was redirected to match the new priorities of the DOE's Office of Basic Energy Sciences (DOE-BES). The DOE program was undergoing reorganization, and the goals now focused on fundamental aspects of energy and carbon capture, conversion, and deposition in energy-rich molecules in both plants and microbes. [11]

This change in research direction led to a reconfiguration of group research projects and to new faculty hires. In 2013, the group project model, first adopted in the 1990s, became the fundamental research model - "research teams addressing research themes" - for all DOE-BES funded research. Three primary research projects were initiated (go to section) to understand the basic science of photosynthetic organisms, including the exploration of photosynthetic processes across multiple scales of biological organization, ranging from subcellular (e.g. photoactive compounds, enzymes, protein complexes and bacterial microcompartments, the thylakoid membrane), to the overall integration of photosynthesis in cells and organisms in their environments. Another aim is to understand photosynthesis in 'real life,' how it is regulated by changes in the natural environment and in response to environmental challenges. The long-term goal uniting these research areas is to improve photosynthetic efficiency and to develop new industrial technological applications.

As of 2020, the Plant Research Lab had over 900 alumni worldwide, many of whom have assumed important academic, industrial, and governmental positions. Since its inception, 18 Plant Research Lab scientists have been elected members of the U.S. National Academy of Sciences, a prestigious honor for scientists in the United States; 21 have been elected American Association for the Advancement of Science Fellows; and 23 have been elected American Society of Plant Biologists Fellows.

Research

Department of Energy Grant

DOE-funded collaborative projects drive the research conducted at the MSU-DOE Plant Research Laboratory. The projects involve all twelve labs at the Plant Research Lab and rely on their diverse areas of expertise to tackle key problems too large to study in individual labs. The research addresses some of today's most challenging scientific questions, with implications for renewables, food sustainability, and medical and industrial technologies.

Other Research and Developed Technologies

In addition to the collaborative projects funded by the DOE, individual laboratories conduct molecular research in diverse areas, including algal biofuels, [12] plant resistance to biotic and abiotic threats, [13] [14] [15] secretory membrane dynamics, [16] dynamics of energy organelles (ie, mitochondria, peroxisomes, and chloroplasts), [17] [18] [19] [20] and molecular genetic and biochemical analyses of photomorphogenesis. [21] The Plant Research Lab has also developed innovative technologies and methods to help address new research questions. Current examples include:

Operations and governance

Michigan State University operates the MSU-DOE Plant Research Laboratory under a contract with the Department of Energy. The institute director reports to both to Michigan State University's College of Natural Sciences and the U.S. Department of Energy, Office of Science, Basic Energy Sciences program.

The Plant Research Lab is located on Michigan State University's East Lansing campus and has groups in both the Plant Biology Laboratory and Molecular Plant Sciences buildings. The institute consists of twelve research laboratories, each headed by a tenure-track faculty member, and has around 150 employees. Its twelve tenure-track faculty also hold appointments in academic departments and programs at Michigan State University.

The Plant Research Lab is solely a research institute and does not grant academic degrees to its students. Consequently, graduate students at the Plant Research Lab are appointed to both the institute and at least one of the affiliated academic departments or programs, the latter of which grant Ph.D. degrees. Postdoctoral associates are appointed to the Plant Research Lab with Michigan State University privileges, such as healthcare and funding.

Laboratory directors

Related Research Articles

<span class="mw-page-title-main">Endosymbiont</span> Organism that lives within the body or cells of another organism

An endosymbiont or endobiont is any organism that lives within the body or cells of another organism most often, though not always, in a mutualistic relationship. (The term endosymbiosis is from the Greek: ἔνδον endon "within", σύν syn "together" and βίωσις biosis "living".) Examples are nitrogen-fixing bacteria, which live in the root nodules of legumes, single-cell algae inside reef-building corals and bacterial endosymbionts that provide essential nutrients to insects.

<span class="mw-page-title-main">Photosynthesis</span> Biological process to convert light into chemical energy

Photosynthesis is a biological process used by many cellular organisms to convert light energy into chemical energy, which is stored in organic compounds that can later be metabolized through cellular respiration to fuel the organism's activities. The term usually refers to oxygenic photosynthesis, where oxygen is produced as a byproduct and some of the chemical energy produced is stored in carbohydrate molecules such as sugars, starch, glycogen and cellulose, which are synthesized from endergonic reaction of carbon dioxide with water. Most plants, algae and cyanobacteria perform photosynthesis; such organisms are called photoautotrophs. Photosynthesis is largely responsible for producing and maintaining the oxygen content of the Earth's atmosphere, and supplies most of the biological energy necessary for complex life on Earth.

<i>Arabidopsis thaliana</i> Model plant species in the family Brassicaceae

Arabidopsis thaliana, the thale cress, mouse-ear cress or arabidopsis, is a small plant from the mustard family (Brassicaceae), native to Eurasia and Africa. Commonly found along the shoulders of roads and in disturbed land, it is generally considered a weed.

<span class="mw-page-title-main">Cyanobacteria</span> Phylum of photosynthesising prokaryotes

Cyanobacteria, also called Cyanobacteriota or Cyanophyta, are a phylum of gram-negative bacteria that obtain energy via photosynthesis. The name cyanobacteria refers to their color, which similarly forms the basis of cyanobacteria's common name, blue-green algae, although they are not usually scientifically classified as algae. They appear to have originated in a freshwater or terrestrial environment. Sericytochromatia, the proposed name of the paraphyletic and most basal group, is the ancestor of both the non-photosynthetic group Melainabacteria and the photosynthetic cyanobacteria, also called Oxyphotobacteria.

Dale Sanders, FRS was Director of the John Innes Centre, an institute for research in plant sciences and microbiology in Norwich, England.

<span class="mw-page-title-main">Carboxysome</span> Bacterial microcompartment containing the enzyme RuBisCo

Carboxysomes are bacterial microcompartments (BMCs) consisting of polyhedral protein shells filled with the enzymes ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO)—the predominant enzyme in carbon fixation and the rate limiting enzyme in the Calvin cycle—and carbonic anhydrase.

<span class="mw-page-title-main">Charles DeLisi</span> American geneticist (born 1941)

Charles Peter DeLisi is an American biomedical scientist and the Metcalf Professor of Science and Engineering at Boston University. He is noted for major contributions to the initiation of the Human Genome Project, for transformative academic leadership, and for research contributions to mathematical and computational immunology, cell biophysics, genomics and protein and nucleic acid structure and function. Recent activities include mathematical finance and climate change.

<span class="mw-page-title-main">Bacterial microcompartment</span> Organelle-like structure in bacteria with a protein shell containing enzymes

Bacterial microcompartments (BMCs) are organelle-like structures found in bacteria. They consist of a protein shell that encloses enzymes and other proteins. BMCs are typically about 40–200 nanometers in diameter and are made entirely of proteins. The shell functions like a membrane, as it is selectively permeable. Other protein-based compartments found in bacteria and archaea include encapsulin nanocompartments and gas vesicles.

<span class="mw-page-title-main">Chloroplast DNA</span> DNA located in cellular organelles called chloroplasts

Chloroplast DNA (cpDNA) is the DNA located in chloroplasts, which are photosynthetic organelles located within the cells of some eukaryotic organisms. Chloroplasts, like other types of plastid, contain a genome separate from that in the cell nucleus. The existence of chloroplast DNA was identified biochemically in 1959, and confirmed by electron microscopy in 1962. The discoveries that the chloroplast contains ribosomes and performs protein synthesis revealed that the chloroplast is genetically semi-autonomous. The first complete chloroplast genome sequences were published in 1986, Nicotiana tabacum (tobacco) by Sugiura and colleagues and Marchantia polymorpha (liverwort) by Ozeki et al. Since then, a great number of chloroplast DNAs from various species have been sequenced.

The N-end rule is a rule that governs the rate of protein degradation through recognition of the N-terminal residue of proteins. The rule states that the N-terminal amino acid of a protein determines its half-life. The rule applies to both eukaryotic and prokaryotic organisms, but with different strength, rules, and outcome. In eukaryotic cells, these N-terminal residues are recognized and targeted by ubiquitin ligases, mediating ubiquitination thereby marking the protein for degradation. The rule was initially discovered by Alexander Varshavsky and co-workers in 1986. However, only rough estimations of protein half-life can be deduced from this 'rule', as N-terminal amino acid modification can lead to variability and anomalies, whilst amino acid impact can also change from organism to organism. Other degradation signals, known as degrons, can also be found in sequence.

<span class="mw-page-title-main">Gloria M. Coruzzi</span> American biologist

Gloria M. Coruzzi is an American molecular biologist specializing in plant systems biology and evolutionary genomics.

Thomas D. Sharkey is a plant biochemist who studies gas exchange between plants and the atmosphere. His research has covered (1) carbon metabolism of photosynthesis from carbon dioxide uptake to carbon export from the Calvin-Benson Cycle, (2) isoprene emission from plants, and (3) abiotic stress tolerance. Four guiding questions are: (1) how leaf photosynthesis affects plant yield, (2) does some carbon fixation follow an oxidative pathway that reduces sugar output but stabilizes photosynthesis, (3) why plants make isoprene, and (4) how plants cope with high temperature.

Robert L. Last is a plant biochemical genomicist who studies metabolic processes that protect plants from the environment and produce products important for animal and human nutrition. His research has covered (1) production and breakdown of essential amino acids, (2) the synthesis and protective roles of Vitamin C and Vitamin E (tocopherols) as well as identification of mechanisms that protect photosystem II from damage, and (3) synthesis and biological functions of plant protective specialized metabolites. Four central questions are: (i) how are leaf and seed amino acids levels regulated, (ii.) what mechanisms protect and repair photosystem II from stress-induced damage, (iii.) how do plants produce protective metabolites in their glandular secreting trichomes (iv.) and what are the evolutionary mechanisms that contribute to the tremendous diversity of specialized metabolites that protect plants from insects and pathogens and are used as therapeutic agents.

Christopher Roland Somerville is a Canadian-American biologist known as a pioneer of Arabidopsis thaliana research. Somerville is currently Professor Emeritus at the University of California, Berkeley and a Program Officer at the Open Philanthropy Project.

Dr. Beronda Montgomery is a writer, science communicator, and researcher. In 2022, she moved to Grinnell College as professor of biology and vice president for academic affairs and dean of the college. Prior to Grinnell, Montgomery served as Michigan State University Foundation Professor in the Departments of Biochemistry & Molecular Biology and of Microbiology & Molecular Genetics. She was also a member of the MSU-DOE Plant Research Laboratory. Her research group investigates how photosynthetic organisms adapt to changes in their environment. Her scholarship extends beyond biology and into studying mentorship and faculty development to develop evidence-based strategies to foster equity and inclusion in academia. Together with Tanisha Williams and other members of the Black Botanists Week organizing committee, Montgomery co-founded and co-organizes Black Botanists Week.

Jennifer Lyn Nemhauser is an American biologist and a Professor of Developmental Biology at the University of Washington in Seattle, Washington. She specializes in synthetic biology, genomics, and signaling dynamics in plants.

<span class="mw-page-title-main">Cheryl Kerfeld</span> American bioengineer

Cheryl Ann Kerfeld is an American bioengineer who is Hannah Distinguished Professor at Michigan State University. She holds a joint position at the Lawrence Berkeley National Laboratory. Her research considers bioinformatics, cellular imaging and structural biology.

Lucas Andrew Staehelin was a retired Swiss-American cell biologist. He was professor emeritus at the University of Colorado Boulder.

Christoph Benning is a German–American plant biologist. He is an MSU Foundation Professor and University Distinguished Professor at Michigan State University. Benning's research into lipid metabolism in plants, algae and photosynthetic bacteria, led him to be named Editor-in-Chief of The Plant Journal in October 2008.

References

  1. Drell, D. (1964). "Chronology of Events in Division of and Medicine Programs". OSTI. doi:10.2172/1095502. OSTI   1095502 . Retrieved October 15, 2020.
  2. Buck, Alice L. (July 1983). A History of the Atomic Energy Commission (PDF). Washington, D.C.: U.S. Department of Energy.
  3. "A Brief History of the Department of Energy". DOE Office of Legacy Management. U.S. Department of Energy. Retrieved October 16, 2020.
  4. "Timeline of Events: 1971 to 1980". DOE Office of Legacy Management. U.S. Department of Energy. Retrieved October 16, 2020.
  5. Newman, T.; de Bruijn, F.J.; et al. (December 1994). "Genes galore: a summary of methods for accessing results from large-scale partial sequencing of anonymous Arabidopsis cDNA clones". Plant Physiology. 106 (4): 1241–1255. doi:10.1104/pp.106.4.1241. PMC   159661 . PMID   7846151 . Retrieved October 29, 2020.
  6. Arondel, V.; Hwang, I.; et al. (November 20, 1992). "Map-based cloning of a gene controlling omega-3 fatty acid desaturation in Arabidopsis". Science. 258 (5086): 1353–1355. Bibcode:1992Sci...258.1353A. doi:10.1126/science.1455229. PMID   1455229 . Retrieved October 29, 2020.
  7. Perrin, R.M.; DeRocher, A.E.; et al. (June 18, 1999). "Xyloglucan fucosyltransferase, an enzyme involved in plant cell wall biosynthesis". Science. 284 (5422): 1976–1979. doi:10.1126/science.284.5422.1976. PMID   10373113 . Retrieved October 29, 2020.
  8. Xu, X.; Kong, R.; deBruijn, F.J.; He, S.Y.; et al. (January 1, 2002). "DNA sequence and genetic characterization of plasmid pFQ11 from Frankia alni strain CpI1". FEMS Microbiology Letters. 207 (1): 103–107. doi: 10.1111/j.1574-6968.2002.tb11036.x . PMID   11886759.
  9. Hoffmann-Benning, S.; Gage, D.A.; et al. (November 2002). "Comparison of peptides in the phloem sap of flowering and non-flowering Perilla and lupine plants using microbore HPLC followed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry". Planta. 216 (1): 140–147. doi:10.1007/s00425-002-0916-0. PMID   12430023. S2CID   24291266 . Retrieved October 29, 2020.
  10. Gao, H.; Brandizzi, F.; et al. (October 21, 2008). "A membrane-tethered transcription factor defines a branch of the heat stress response in Arabidopsis thaliana". Proceedings of the National Academy of Sciences of the United States of America. 105 (42): 16398–16403. Bibcode:2008PNAS..10516398G. doi: 10.1073/pnas.0808463105 . PMC   2571009 . PMID   18849477.
  11. "Basic Energy Sciences homepage". U.S. Department of Energy. Retrieved October 29, 2020.
  12. Du, Z.; Lucker, B.F.; et al. (February 2018). "Galactoglycerolipid Lipase PGD1 Is Involved in Thylakoid Membrane Remodeling in Response to Adverse Environmental Conditions in Chlamydomonas". The Plant Cell. 30 (2): 447–465. doi:10.1105/tpc.17.00446. PMC   5868692 . PMID   29437989. S2CID   4465149 . Retrieved November 3, 2020.
  13. Major, I.T.; Gou, Q.; et al. (June 2020). "A Phytochrome B-Independent Pathway Restricts Growth at High Levels of Jasmonate Defense". Plant Physiology. 183 (2): 733–749. doi:10.1104/pp.19.01335. PMC   7271779 . PMID   32245790 . Retrieved November 3, 2020.
  14. Kim, Y.; Gilmour, S.J.; et al. (January 6, 2020). "Arabidopsis CAMTA Transcription Factors Regulate Pipecolic Acid Biosynthesis and Priming of Immunity Genes". Molecular Plant. 13 (1): 157–168. doi: 10.1016/j.molp.2019.11.001 . PMID   31733370.
  15. Santiago, J.P.; Ward, J.M.; et al. (August 28, 2020). "Phaseolus vulgaris SUT1.1 is a high affinity sucrose‐proton co‐transporter". Plant Direct. 4 (1): e00260. doi:10.1002/pld3.260. PMC   7453976 . PMID   32885136. S2CID   221458759.
  16. Ko, D.K.; Brandizzi, F. (October 24, 2020). "A temporal hierarchy underpins the transcription factor‐DNA interactome of the maize UPR". The Plant Journal. 105 (1): 254–270. doi:10.1111/tpj.15044. ISSN   0960-7412. PMC   7942231 . PMID   33098715.
  17. Zhang, Xinchun; Hu, Jianping (February 2010). "The Arabidopsis Chloroplast Division Protein DYNAMIN-RELATED PROTEIN5B Also Mediates Peroxisome Division". The Plant Cell. 22 (2): 431–442. doi:10.1105/tpc.109.071324. ISSN   1040-4651. PMC   2845408 . PMID   20179140.
  18. Aung, Kyaw; Hu, Jianping (2011-12-01). "The Arabidopsis Tail-Anchored Protein PEROXISOMAL AND MITOCHONDRIAL DIVISION FACTOR1 Is Involved in the Morphogenesis and Proliferation of Peroxisomes and Mitochondria". The Plant Cell. 23 (12): 4446–4461. doi:10.1105/tpc.111.090142. ISSN   1532-298X. PMC   3269876 . PMID   22147290.
  19. Pan, Ronghui; Jones, A. Daniel; Hu, Jianping (2014-02-28). "Cardiolipin-Mediated Mitochondrial Dynamics and Stress Response in Arabidopsis". The Plant Cell. 26 (1): 391–409. doi:10.1105/tpc.113.121095. ISSN   1532-298X. PMC   3963584 . PMID   24443516.
  20. Pan, Ronghui; Satkovich, John; Hu, Jianping (2016-11-15). "E3 ubiquitin ligase SP1 regulates peroxisome biogenesis in Arabidopsis". Proceedings of the National Academy of Sciences. 113 (46): E7307–E7316. doi: 10.1073/pnas.1613530113 . ISSN   0027-8424. PMC   5135305 . PMID   27799549.
  21. Rohnke, B.; Rodríguez Pérez, K.J.; et al. (May 26, 2020). "Linking the Dynamic Response of the Carbon Dioxide-Concentrating Mechanism to Carbon Assimilation Behavior in Fremyella diplosiphon". mBio. 11 (3): e01052-20. doi:10.1128/mBio.01052-20. PMC   7251215 . PMID   32457252 . Retrieved November 3, 2020.
  22. Ferlez, B.; Sutter, M.; et al. (July 2019). "A designed bacterial microcompartment shell with tunable composition and precision cargo loading". Metabolic Engineering. 54: 286–291. doi:10.1016/j.ymben.2019.04.011. PMC   6884132 . PMID   31075444.
  23. Sutter, M.; McGuire, S.; et al. (March 22, 2019). "Structural Characterization of a Synthetic Tandem-Domain Bacterial Microcompartment Shell Protein Capable of Forming Icosahedral Shell Assemblies". ACS Synthetic Biology. 8 (4): 668–674. doi:10.1021/acssynbio.9b00011. PMC   6884138 . PMID   30901520.
  24. Hagen, A.R.; Plegaria, J.S.; et al. (October 22, 2018). "In Vitro Assembly of Diverse Bacterial Microcompartment Shell Architectures". Nano Letters. 18 (11): 7030–7037. Bibcode:2018NanoL..18.7030H. doi:10.1021/acs.nanolett.8b02991. PMC   6309364 . PMID   30346795.
  25. Hagen, A.R.; Sutter, M.; et al. (July 23, 2018). "Programmed loading and rapid purification of engineered bacterial microcompartment shells". Nature Communications. 9 (1): 2881. Bibcode:2018NatCo...9.2881H. doi:10.1038/s41467-018-05162-z. PMC   6056538 . PMID   30038362.
  26. Weiss, T.L.; Young, E.J.; et al. (November 2017). "A synthetic, light-driven consortium of cyanobacteria and heterotrophic bacteria enables stable polyhydroxybutyrate production". Metabolic Engineering. 44 (1): 236–245. doi:10.1016/j.ymben.2017.10.009. PMID   29061492 . Retrieved November 2, 2020.
  27. Du, Z.; Alvaro, J.; et al. (June 22, 2018). "Enhancing oil production and harvest by combining the marine alga Nannochloropsis oceanica and the oleaginous fungus Mortierella elongata". Biotechnology for Biofuels. 11 (1): 174. doi: 10.1186/s13068-018-1172-2 . PMC   6013958 . PMID   29977335. S2CID   49429347.
  28. Young, E.J.; Sakkos, J.K.; et al. (November 20, 2019). "Visualizing in Vivo Dynamics of Designer Nanoscaffolds". Nano Letters. 20 (1): 208–217. doi:10.1021/acs.nanolett.9b03651. OSTI   1608250. PMID   31747755. S2CID   208215855 . Retrieved November 2, 2020.
  29. Poliner, E.; Takeuchi, T.; et al. (March 8, 2018). "Nontransgenic Marker-Free Gene Disruption by an Episomal CRISPR System in the Oleaginous Microalga, Nannochloropsis oceanica CCMP1779". ACS Synthetic Biology. 7 (4): 962–968. doi:10.1021/acssynbio.7b00362. PMC   6616531 . PMID   29518315.
  30. Sadre, R.; Kuo, P.; et al. (February 20, 2019). "Cytosolic lipid droplets as engineered organelles for production and accumulation of terpenoid biomaterials in leaves". Nature Communications. 10 (1): 853. Bibcode:2019NatCo..10..853S. doi:10.1038/s41467-019-08515-4. PMC   6382807 . PMID   30787273.
  31. Cruz, Jeffrey A.; Savage, Linda J.; et al. (June 22, 2016). "Dynamic Environmental Photosynthetic Imaging Reveals Emergent Phenotypes". Cell Systems. 2 (6): 365–377. doi:10.1016/j.cels.2016.06.001. hdl: 10044/1/82670 . PMID   27336966 . Retrieved October 16, 2020.
  32. Kuhlgert, Sebastian; Austic, Greg; et al. (October 1, 2016). "MultispeQ Beta: a tool for large-scale plant phenotyping connected to the open PhotosynQ network". Royal Society Open Science. 3 (10): 160592. Bibcode:2016RSOS....360592K. doi:10.1098/rsos.160592. PMC   5099005 . PMID   27853580 . Retrieved October 1, 2020.
  33. "PhotosynQ Website" . Retrieved October 20, 2020.
  34. Lucker, Ben F.; Hall, Christopher C.; et al. (October 1, 2014). "The environmental photobioreactor (ePBR): An algal culturing platform for simulating dynamic natural environments". Algal Research. 6 (PartB): 242–249. doi:10.1016/j.algal.2013.12.007 . Retrieved October 16, 2020.