Matthew Rabinowitz

Last updated
Matthew Rabinowitz
Born (1973-02-04) 4 February 1973 (age 50)
Johannesburg, South Africa
Years active1998–present
Parents
Awards See list

Matthew Rabinowitz (born 4 February 1973) is a South African-American entrepreneur and investor. He is the co-founder and executive chairman of Natera (NTRA), a clinical genetic testing company. He serves as executive chairman, board member, adviser and angel investor to several companies and non-profits in diagnostics, biotech, machine learning, health services and nature conservation. [1]

Contents

Rabinowitz has been a consulting professor in Aeronautics and Astronautics at Stanford University, visiting faculty in Genetics at Harvard Medical School. His technologies have generated over 100 patents [2] and peer-reviewed publications. [3]

Early life and education

Matthew Rabinowitz was born on 4 February 1973 in Johannesburg, South Africa. His parents, Bernard “Bokkie” Rabinowitz and Ruth Rabinowitz (née Zilibowitz) were both doctors. From 1955 to 1985, Bokkie Rabinowitz was a general surgeon [4] in South Africa after which he continued surgical teaching until 1996. His interests included trauma, HIV and the surgical conditions of Africa. In 1996, he became the Superintendent of the Baragwanath Hospital. [4] Ruth was an MD who also qualified as a homeopath. As the South African Apartheid state was coming to an end, Ruth entered political activism. She was a Member of Parliament (MP) and Senator in South Africa, representing the Inkatha Freedom Party for 15 years as Health Spokesperson. [5] [6]

Rabinowitz attended Sandown Primary School and Redhill School (Johannesburg) in South Africa where he won the South African National Science Olympiad in 1990. [7] [8] In 1991, he attended the University of the Witwatersrand where he studied astronomy, maths, philosophy, accounting and electrical engineering. In 1992, he relocated to the US after receiving a scholarship to attend Stanford University where he completed a Bachelor of Arts, Humanities and Social Sciences. [9] In 2000, Rabinowitz completed a Ph.D. in Electrical Engineering with a minor in Aeronautics and Astronautics. He received the Levine Award and Terman Award for outstanding research and academics in the Departments of Physics and the School of Engineering. He was granted a graduate fellowship to the Stanford School of Engineering, where he completed a Ph.D. in Electrical Engineering. [9]

Career

In 1998, Rabinowitz co-founded Panopticon, an intelligent online merchandising company which sold for $100 million in 2000. [10]

In 2000, he founded the Rosum Corporation with the creators of GPS. Under Rabinowitz’ leadership as CEO (and CTO a few years later), Rosum developed a location technology using digital TV signals to augment GPS for positioning indoors and urban areas where GPS signal is inactive. [11]

In 2004, Rabinowitz served for 8 years as a consulting professor in the Stanford School of Engineering, Department of Aeronautics and Astronautics. [12]

Rabinowitz became actively involved in genetics research after events affecting his family. [13] Following advances in the Human Genome Project, in 2005, Rabinowitz founded Natera (NTRA) to deliver a range of prenatal, oncology and organ transplant tests, and genetic counseling services to change the management of disease. [14] [15] Natera’s flagship noninvasive prenatal test, Panorama, has generated roughly 50 peer-reviewed publications and has changed the management of pregnancy while reducing the use of invasive tests like amniocentesis. [16]

Rabinowitz is the co-founder and chairman of MyOme, [17] a health technology company founded in 2017 that aims to reduce medical costs and improve health outcomes using whole genome sequencing (WGS) and polygenic predictive modeling. MyOme is developing a range of WGS-related diagnostics and interventions, such as in-vitro fertilization cycles with whole-genome analysis to aid embryo selection by evaluating polygenic disease models for cancer, autoimmune, cardiovascular, metabolic, and cognitive conditions. [18] [19] MyOme has combined clinical data with whole-genome genetic models that work across diverse ethnicities to enhance risk prediction for breast cancer and other common phenotypes. [20] The company's investors include Sequoia Capital, Founders Fund, Foresite Capital, Healthcare Venture Partners and SoftBank Japan. [21] [22]

Rabinowitz is the founder and executive chairman of NatureEye, a drone technology start-up that provides alternative profit models and anti-poaching tools for wildlife conservancies. [23]

Rabinowitz began as visiting faculty in the Harvard genetic department in 2018 and mentored various projects out of the Wyss Institute at Harvard Medical School. In 2022 he joined one of those projects, Marble Therapeutics, and serves as its executive chairman. The company develops anti-aging therapeutics that leverage gene therapies to modulate gene signaling pathways. Its technology uses chaos theory and nonlinear dynamical modeling of longitudinal genetic data. [24]

Personal life

In 2003, Rabinowitz’s sister gave birth to a baby with Down syndrome who died soon after. [25] Rabinowitz said the experience motivated him to establish a start-up that offered advanced informatics and clinical genetic testing, such as screening tests for women as an alternative to invasive amniocentesis to learn of inherited or genetic disorders early in pregnancy. [26]

Awards and recognition

Related Research Articles

<span class="mw-page-title-main">Bill Hewlett</span> American engineer

William Redington Hewlett was an American engineer and the co-founder, with David Packard, of the Hewlett-Packard Company (HP).

<span class="mw-page-title-main">Gordon Moore</span> American businessman (1929–2023)

Gordon Earle Moore was an American businessman, engineer, and the co-founder and emeritus chairman of Intel Corporation. He proposed Moore's law which makes the observation that the number of transistors in an integrated circuit (IC) doubles about every two years.

<span class="mw-page-title-main">David Packard</span> American electrical engineer

David Packard was an American electrical engineer and co-founder, with Bill Hewlett, of Hewlett-Packard (1939), serving as president (1947–64), CEO (1964–68), and chairman of the board of HP. He served as U.S. Deputy Secretary of Defense from 1969 to 1971 during the Nixon administration. Packard served as president of the Uniformed Services University of the Health Sciences (USU) from 1976 to 1981 and chairman of its board of regents from 1973 to 1982. He was a member of the Trilateral Commission. Packard was the recipient of the Presidential Medal of Freedom in 1988 and is noted for many technological innovations and philanthropic endeavors.

<span class="mw-page-title-main">N. R. Narayana Murty</span> Indian businessman (born 1946)

Nagavara Ramarao Narayana Murthy is an Indian billionaire businessman. He is one of the seven co-founders of Infosys, and has previously served as the chairman, chief executive officer (CEO), president, and chief mentor of the company before retiring and taking the title chairman emeritus. As of April 2023, his net worth was estimated to be $4.1 billion, making him the 711th richest person in the world according to Forbes.

<span class="mw-page-title-main">Omics</span> Suffix in biology

The branches of science known informally as omics are various disciplines in biology whose names end in the suffix -omics, such as genomics, proteomics, metabolomics, metagenomics, phenomics and transcriptomics. Omics aims at the collective characterization and quantification of pools of biological molecules that translate into the structure, function, and dynamics of an organism or organisms.

<span class="mw-page-title-main">Bradford Parkinson</span> American engineer

Bradford Parkinson is an American engineer and inventor, retired United States Air Force Colonel and Emeritus Professor at Stanford University. He is best known as the lead architect, advocate and developer, with early contributions from Ivan Getting and Roger Easton, of the Air Force NAVSTAR program, better known as Global Positioning System.

<span class="mw-page-title-main">Personalized medicine</span> Medical model that tailors medical practices to the individual patient

Personalized medicine, also referred to as precision medicine, is a medical model that separates people into different groups—with medical decisions, practices, interventions and/or products being tailored to the individual patient based on their predicted response or risk of disease. The terms personalized medicine, precision medicine, stratified medicine and P4 medicine are used interchangeably to describe this concept though some authors and organisations use these expressions separately to indicate particular nuances.

<span class="mw-page-title-main">George Church (geneticist)</span> American geneticist

George McDonald Church is an American geneticist, molecular engineer, chemist, serial entrepreneur, and pioneer in personal genomics and synthetic biology. He is the Robert Winthrop Professor of Genetics at Harvard Medical School, Professor of Health Sciences and Technology at Harvard University and Massachusetts Institute of Technology, and a founding member of the Wyss Institute for Biologically Inspired Engineering at Harvard. Through his Harvard lab Church has co-founded around 50 biotech companies pushing the boundaries of innovation in the world of life sciences and making his lab as a hotbed of biotech startup activity in Boston. In 2018, the Church lab at Harvard made a record by spinning off 16 biotech companies in one year. The Church lab works on research projects that are distributed in diverse areas of modern biology like developmental biology, neurobiology, info processing, medical genetics, genomics, gene therapy, diagnostics, chemistry & bioengineering, space biology & space genetics, and ecosystem. Research and technology developments at the Church lab have impacted or made direct contributions to nearly all "next-generation sequencing (NGS)" methods and companies. In 2017, Time magazine listed him in Time 100, the list of 100 most influential people in the world. In 2022, he was featured among the most influential people in biopharma by Fierce Pharma, and was listed among the top 8 famous geneticists of all time in human history. As of January 2023, Church serves as a member of the Bulletin of the Atomic Scientists' Board of Sponsors, established by Albert Einstein.

Illumina, Inc. is an American biotechnology company, headquartered in San Diego, California, and it serves more than 140 countries. Incorporated on April 1, 1998, Illumina develops, manufactures, and markets integrated systems for the analysis of genetic variation and biological function. The company provides a line of products and services that serves the sequencing, genotyping and gene expression, and proteomics markets.

<span class="mw-page-title-main">Bill Dally</span> American computer scientist and educator (born 1960)

William James Dally is an American computer scientist and educator. Since 2021, he has been a member of the President’s Council of Advisors on Science and Technology (PCAST).

<span class="mw-page-title-main">Whole genome sequencing</span> Determining nearly the entirety of the DNA sequence of an organisms genome at a single time

Whole genome sequencing (WGS), also known as full genome sequencing, complete genome sequencing, or entire genome sequencing, is the process of determining the entirety, or nearly the entirety, of the DNA sequence of an organism's genome at a single time. This entails sequencing all of an organism's chromosomal DNA as well as DNA contained in the mitochondria and, for plants, in the chloroplast.

Sequenom is an American company based in San Diego, California. It develops enabling molecular technologies, and highly sensitive laboratory genetic tests for NIPT. Sequenom's wholly owned subsidiarity, Sequenom Center for Molecular Medicine (SCMM), offers multiple clinical molecular genetics tests to patients, including MaterniT21, plus a noninvasive prenatal test for trisomy 21, trisomy 18, and trisomy 13, and the SensiGene RHD Fetal RHD genotyping test.

<span class="mw-page-title-main">Chris Toumazou</span> British academic

Christofer "Chris" Toumazou, FRS, FREng, FMedSci, FIET, FIEEE, FCGI, FRSM, CEng is a British Cypriot electronic engineer.

<span class="mw-page-title-main">Paul G. Kaminski</span> American scientist

Paul Garrett Kaminski is a technologist and former U.S. government official, best known for his leading role in the development of stealth aircraft.

Natera, Inc. is a clinical genetic testing company based in Austin, Texas that specializes in non-invasive, cell-free DNA (cfDNA) testing technology, with a focus on women’s health, cancer, and organ health. Natera’s proprietary technology combines novel molecular biology techniques with a suite of bioinformatics software that allows detection down to a single molecule in a tube of blood. Natera operates CAP-accredited laboratories certified under the Clinical Laboratory Improvement Amendments (CLIA) in San Carlos, California and Austin, Texas.

<span class="mw-page-title-main">Euan Ashley</span> American professor of medicine

Euan Angus Ashley is a Scottish physician, scientist, author, and founder based at Stanford University in California where he is Associate Dean in the School of Medicine and holds the Roger and Joelle Burnell Chair of Genomics and Precision Health. He is known for helping establish the field of medical genomics.

<span class="mw-page-title-main">Polygenic score</span> Numerical score aimed at predicting a trait based on variation in multiple genetic loci

In genetics, a polygenic score (PGS), also called a polygenic index (PGI), polygenic risk score (PRS), genetic risk score, or genome-wide score, is a number that summarizes the estimated effect of many genetic variants on an individual's phenotype, typically calculated as a weighted sum of trait-associated alleles. It reflects an individual's estimated genetic predisposition for a given trait and can be used as a predictor for that trait. In other words, it gives an estimate of how likely an individual is to have a given trait only based on genetics, without taking environmental factors into account. Polygenic scores are widely used in animal breeding and plant breeding due to their efficacy in improving livestock breeding and crops. In humans, polygenic scores are typically generated from genome-wide association study (GWAS) data.

<span class="mw-page-title-main">James Spilker</span>

James Julius Spilker Jr. was an American engineer and a consulting professor in the Aeronautics and Astronautics Department at Stanford University. He was one of the principal architects of the Global Positioning System (GPS). He was a co-founder of the space communications company Stanford Telecommunications, and was most recently executive chairman of AOSense Inc., Sunnyvale, CA.

<span class="mw-page-title-main">Marty Bradley</span> American aerospace engineer

Marty Bradley is an American aerospace engineer who specializes in advanced propulsion, electric aircraft, and sustainable aviation. He is a fellow of the American Institute of Aeronautics and Astronautics (AIAA), an adjunct professor of aerospace and mechanical engineering practice at the University of Southern California (USC), and a sustainable aviation consultant.

References

  1. ↑ "Matthew Rabinowitz". World Economic Forum. Retrieved 25 January 2023.
  2. ↑ "Patents by Inventor Matthew Rabinowitz". JUSTIA Patents.
  3. ↑ "Peer-reviewed Publications". Natera. Natera. Retrieved 25 January 2023.
  4. 1 2 "Bernard (Bokkie) Rabinowitz" (PDF). The Scientific Electronic Library Online. Retrieved 7 April 2023.
  5. ↑ "Feed In Tariff for Renewable Energy, Private Members' Bill". Inkatha Freedom Party.
  6. ↑ "Inventory of the private collection of Inkatha Freeadom Party" (PDF). University of the Free State.
  7. ↑ "Stanford eCorner - Irreverence Pays Benefits" (PDF). eCorner.
  8. ↑ Bleby, Michael (22 August 2007). "South Africa: Delicate Detective Work At the Genetic Frontier" . Retrieved 25 January 2023.
  9. 1 2 "Matthew Rabinowitz - IEEE Xplore". IEEE. Retrieved 5 April 2023.
  10. ↑ "Broadbase Software to Buy Panop.com". The New York Times. 8 July 2000. Retrieved 25 January 2023.
  11. ↑ Brown, Steven E.F. (15 April 2008). "Rosum Corp. raises $15 million". San Francisco Business Times. Retrieved 25 January 2023.
  12. ↑ Rabinowitz, Matthew; Spilker, James J. (December 2004). "Augmenting GPS with Television Signals for Reliable Indoor Positioning". Navigation. pp. 269–282. doi:10.1002/j.2161-4296.2004.tb00358.x . Retrieved 29 May 2023.
  13. ↑ Anderson, Chris (25 August 2021). "Much More than Child's Play". Inside Precision Medicine. Retrieved 29 May 2023.
  14. ↑ "Matthew Rabinowitz, Natera Co-Founder and Executive Chairman of the Board, Makes Additional Investment in Natera". Business Insider. 16 May 2022. Retrieved 25 January 2023.
  15. ↑ "Matthew Rabinowitz, Natera Co-Founder and Executive Chairman of the Board, Makes Additional Investment in Natera". Yahoo Finance. 16 May 2022. Retrieved 25 January 2023.
  16. ↑ "How a Family Tragedy Inspired This Founder to Help Pregnant Women". Inc. Retrieved 5 April 2023.
  17. ↑ "About - MyOme". MyOme. MyOme. Retrieved 25 January 2023.
  18. ↑ Kumar, Akash (2022). "Whole-genome risk prediction of common diseases in human preimplantation embryos". Nature Medicine. Nature.com. 28 (3): 513–516. doi:10.1038/s41591-022-01735-0. PMC   8938270 . PMID   35314819.
  19. ↑ "Scientists say they can read nearly the whole genome of an IVF-created embryo". www.science.org. Retrieved 29 May 2023.
  20. ↑ Ray, Forest (15 June 2022). "MyOme Develops Cross-Ancestry Breast Cancer Polygenic Risk Score, Plans Product Launch". GenomeWeb. Retrieved 25 January 2023.
  21. ↑ "Matthew Rabinowitz". Sequoia Capital. Retrieved 25 January 2023.
  22. ↑ Diphoko, Wesley (5 April 2022). "This SA born Venture Capitalist is taking over the world". Fast Company. Retrieved 25 January 2023.
  23. ↑ "NatureEye helps conservation while delivering a unique experience". NatureEye. NatureEye. Retrieved 25 January 2023.
  24. ↑ Zhavoronkov, Alex (31 October 2022). "This Harvard Female Scientist Wants To Use Genetics To Reverse The Age Of Your Skin". Forbes. Retrieved 25 January 2023.
  25. ↑ Tozzi, John (26 April 2013). "Innovator: Matt Rabinowitz Sifts Gene Data for Healthy Pregnancies". Bloomberg. Retrieved 25 January 2023.
  26. ↑ White, Tracie. "Rock solid science, passion help fuel successful startups". Scope Blog - Stanford Medicine. Stanford Medicine. Retrieved 25 January 2023.
  27. ↑ "Matthew Rabinowitz | Innovators Under 35". www.innovatorsunder35.com. Retrieved 7 April 2023.
  28. ↑ "2006 Scott Helt Memorial Award For the best paper published in the IEEE Transactions on Broadcasting". IEEE. December 2006. pp. 417–417. doi:10.1109/TBC.2006.887344 . Retrieved 7 April 2023.
  29. ↑ "World Economic Forum - 2006 Tech Pioneers in Information Technology". World Bank. Retrieved 7 April 2023.
  30. ↑ "Technology Pioneers 2014" (PDF). WEF. Retrieved 7 April 2023.
  31. ↑ "2012-2018 Winners". Edison Awards. Retrieved 7 April 2023.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.