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Mel Krajden OBC is a physician and professor of Pathology and Laboratory Medicine at the University of British Columbia in Vancouver, British Columbia, Canada. He is the medical director of the BCCDC Public Health Laboratory. [1] Dr. Krajden obtained his BSc, MD, and FRCPC (Internal Medicine) at McGill University, followed by a fellowship in Infectious Diseases at Stanford University. He is also the medical director of the Public Health Laboratory at the British Columbia Centre for Disease Control. His research focuses on the prevention and care of hepatitis, human papillomavirus, and human immunodeficiency virus.
During the COVID-19 pandemic Dr. Krajden played a key leadership role in Canada's public health response. Under his direction, the BC Centre for Disease Control, Public Health Laboratory, developed an accredited COVID-19 test within 10 days of the SARS-CoV-2 genome being released. [3] He was a leading member of the national government's COVID-19 Immunity Task Force. He led many COVID-19 research projects including:
Dr. Krajden was also a collaborator on many COVID-19 research projects, including: COVID-19 Germline Analysis, [10] Immunological research on antibody and cell-mediated responses, [11] examining the biological properties of Variants of Concern and well therapeutics work, [12] the role ACEII plays, [13] and, the infection rate of COVID-19 in children and youths. [14]
Krajden serves on Health Canada's Expert Advisory Committee on Blood Regulation and Expert Advisory Committee on Cells, Tissues, and Organs. His role on these is because of his "expertise in medical microbiology, immunology, internal medicine and infectious diseases". [15] Krajden is also the Treasurer of the Association of Medical Microbiology and Infectious Disease Canada. [16]
In addition to more than 400 publications in peer-reviewed journals, [17] Krajden has been quoted in the lay press on subjects such as human metapneumovirus, [18] and SARS. [19]
Krajden was appointed as a member of the Order of British Columbia in 2020. [20]
Coronaviruses are a group of related RNA viruses that cause diseases in mammals and birds. In humans and birds, they cause respiratory tract infections that can range from mild to lethal. Mild illnesses in humans include some cases of the common cold, while more lethal varieties can cause SARS, MERS and COVID-19, which is causing the ongoing pandemic. In cows and pigs they cause diarrhea, while in mice they cause hepatitis and encephalomyelitis.
Marco A. Marra is a Distinguished Scientist and Director of Canada's Michael Smith Genome Sciences Centre at the BC Cancer Research Centre and Professor of Medical Genetics at the University of British Columbia (UBC). He also serves as UBC Canada Research Chair in Genome Science for the Canadian Institutes of Health Research and is an inductee in the Canadian Medical Hall of Fame. Marra has been instrumental in bringing genome science to Canada by demonstrating the pivotal role that genomics can play in human health and disease research.
Serology is the scientific study of serum and other body fluids. In practice, the term usually refers to the diagnostic identification of antibodies in the serum. Such antibodies are typically formed in response to an infection, against other foreign proteins, or to one's own proteins. In either case, the procedure is simple.
Severe acute respiratory syndrome coronavirus 1 is a strain of coronavirus that causes severe acute respiratory syndrome (SARS), the respiratory illness responsible for the 2002–2004 SARS outbreak. It is an enveloped, positive-sense, single-stranded RNA virus that infects the epithelial cells within the lungs. The virus enters the host cell by binding to angiotensin-converting enzyme 2. It infects humans, bats, and palm civets. The SARS-CoV-1 outbreak was largely brought under control by simple public health measures. Testing people with symptoms, isolating and quarantining suspected cases, and restricting travel all had an effect. SARS-CoV-1 was most transmissible when patients were sick, and so by isolating those with symptoms, you could effectively prevent onward spread.
Medical microbiology, the large subset of microbiology that is applied to medicine, is a branch of medical science concerned with the prevention, diagnosis and treatment of infectious diseases. In addition, this field of science studies various clinical applications of microbes for the improvement of health. There are four kinds of microorganisms that cause infectious disease: bacteria, fungi, parasites and viruses, and one type of infectious protein called prion.
Walter Ian Lipkin is the John Snow Professor of Epidemiology at the Mailman School of Public Health at Columbia University and a professor of Neurology and Pathology at the College of Physicians and Surgeons at Columbia University. He is also director of the Center for Infection and Immunity, an academic laboratory for microbe hunting in acute and chronic diseases. Lipkin is internationally recognized for his work with West Nile virus, SARS and COVID-19.
The BC Centre for Disease Control is the public health arm for British Columbia's Provincial Health Services Authority.
B. Brett Finlay, is a Canadian microbiologist well known for his contributions to understanding how microbes cause disease in people and developing new tools for fighting infections, as well as the role the microbiota plays in human health and disease. Science.ca describes him as one of the world's foremost experts on the molecular understanding of the ways bacteria infect their hosts. He also led the SARS Accelerated Vaccine Initiative (SAVI) and developed vaccines to SARS and a bovine vaccine to E. coli O157:H7. His current research interests focus on pathogenic E. coli and Salmonella pathogenicity, and the role of the microbiota in infections, asthma, and malnutrition. He is currently the UBC Peter Wall Distinguished Professor and a Professor in the Michael Smith Laboratories, Microbiology and Immunology, and Biochemistry and Molecular Biology, and Co-director and Senior Fellow for the CIFAR Humans and Microbes program. He is also co-author of the book Let Them Eat Dirt: Saving Your Child from an Oversanitized World and The Whole-Body Microbiome: How to Harness Microbes - Inside and Out - For Lifelong Health. Finlay is the author of over 500 publications in peer-reviewed journals and served as editor of several professional publications for many years.
Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is a strain of coronavirus that causes COVID-19, the respiratory illness responsible for the ongoing COVID-19 pandemic. The virus previously had a provisional name, 2019 novel coronavirus (2019-nCoV), and has also been called the human coronavirus 2019. First identified in the city of Wuhan, Hubei, China, the World Health Organization declared the outbreak a public health emergency of international concern on January 30, 2020, and a pandemic on March 11, 2020. SARS‑CoV‑2 is a positive-sense single-stranded RNA virus that is contagious in humans.
The Wuhan Institute of Virology, Chinese Academy of Sciences is a research institute on virology administered by the Chinese Academy of Sciences (CAS), which reports to the State Council of the People's Republic of China. The institute is one of nine independent organisations in the Wuhan Branch of the CAS. Located in Jiangxia District, Wuhan, Hubei, it opened mainland China's first biosafety level 4 (BSL-4) laboratory. The institute has collaborated with the Galveston National Laboratory in the United States, the Centre International de Recherche en Infectiologie in France, and the National Microbiology Laboratory in Canada. The institute has been an active premier research center for the study of coronaviruses.
Coronavirus disease 2019 (COVID-19) is a contagious disease caused by a virus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The first known case was identified in Wuhan, China, in December 2019. The disease quickly spread worldwide, resulting in the COVID-19 pandemic.
Bonnie J. Fraser Henry is a Canadian physician and public servant who has been the provincial health officer at the British Columbia Ministry of Health since 2014. Henry is also a clinical associate professor at the University of British Columbia. She is a specialist in public health and preventive medicine, and is a family doctor. In her role as provincial health officer, Henry notably led the response to COVID-19 in British Columbia (BC).
Angela Lynn Rasmussen is an American virologist at the Vaccine and Infectious Disease Organization at the University of Saskatchewan in Canada.
Allison Joan McGeer is a Canadian infectious disease specialist in the Sinai Health System, and a professor in the Department of Laboratory Medicine and Pathobiology at the University of Toronto. She also appointed at the Dalla Lana School of Public Health and a Senior Clinician Scientist at the Lunenfeld-Tanenbaum Research Institute, and is a partner of the National Collaborating Centre for Infectious Diseases. McGeer has led investigations into the severe acute respiratory syndrome outbreak in Toronto and worked alongside Donald Low. During the COVID-19 pandemic, McGeer has studied how SARS-CoV-2 survives in the air and has served on several provincial committees advising aspects of the Government of Ontario's pandemic response.
This article documents the chronology and epidemiology of SARS-CoV-2 in 2019, the virus that causes coronavirus disease 2019 (COVID-19) and is responsible for the COVID-19 pandemic. The first human cases of COVID-19 known to have been identified were in Wuhan, Hubei, China, in December 2019. It marked the beginning of the 2019–2020 COVID-19 outbreak in mainland China.
The COVID-19 Immunity Task Force (CITF) is one of the Government of Canada's early efforts to track the 2020 coronavirus pandemic. An external, dedicated secretariat will help maximize the efficiency of the CITF's work.
Deborah M. Money is a Canadian obstetric and gynaecological infectious disease specialist. As a professor at the University of British Columbia, she was the first non-US President of the Infectious Diseases Society for Obstetrics and Gynecology from 2010 until 2012.
Agatha Jassem is a Canadian clinical microbiologist and the program head of the Virology Lab at the British Columbia Centre for Disease Control Public Health Laboratory, and a clinical assistant professor in the Department of Pathology & Laboratory Medicine at the University of British Columbia in Vancouver, British Columbia, Canada.
The New Zealand Microbiology Network (NZMN) is an advisory group to the Ministry of Health in New Zealand. It was established in 2014 through a contract from the Ministry of Health to the Institute of Environmental Science and Research (ESR).
Robert Conrad Brunham is a Canadian infectious disease specialist. He is the former Director of the UBC Centre for Disease Control and executive director and Scientific Director of the British Columbia Centre for Disease Control.