Metallothionein 1G

MT1G
Identifiers
Aliases	MT1G , MT1, MT1K, Metallothionein 1G
External IDs	OMIM: 156353; GeneCards: MT1G; OMA:MT1G - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q13 Start 56,666,730 bp [1] End 56,668,065 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon right lobe of liver mucosa of ileum human kidney right lobe of thyroid gland left lobe of thyroid gland buccal mucosa cell kidney tubule body of pancreas rectum n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding protein binding metal ion binding Cellular component cytoplasm perinuclear region of cytoplasm nucleus Biological process monocyte activation cellular response to copper ion cellular response to vascular endothelial growth factor stimulus negative regulation of growth cellular response to cadmium ion monocyte differentiation cellular response to zinc ion cellular zinc ion homeostasis detoxification of copper ion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4495 n/a Ensembl ENSG00000125144 n/a UniProt P13640 n/a RefSeq (mRNA) NM_005950 NM_001301267 n/a RefSeq (protein) NP_001288196 NP_005941 n/a Location (UCSC) Chr 16: 56.67 – 56.67 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Metallothionein-1G is a protein that in humans is encoded by the MT1G gene. ^{[3] [4] [5]}

References

1. GRCh38: Ensembl release 89: ENSG00000125144 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Foster R, Jahroudi N, Varshney U, Gedamu L (Sep 1988). "Structure and expression of the human metallothionein-IG gene. Differential promoter activity of two linked metallothionein-I genes in response to heavy metals". J Biol Chem. 263 (23): 11528–35. doi: 10.1016/S0021-9258(18)37990-0 . PMID   3403543.
4. Karin M, Eddy RL, Henry WM, Haley LL, Byers MG, Shows TB (Oct 1984). "Human metallothionein genes are clustered on chromosome 16". Proc Natl Acad Sci U S A. 81 (17): 5494–8. Bibcode:1984PNAS...81.5494K. doi: 10.1073/pnas.81.17.5494 . PMC   391732 . PMID   6089206.
5. "Entrez Gene: MT1G metallothionein 1G".

Further reading

• West AK, Stallings R, Hildebrand CE, et al. (1991). "Human metallothionein genes: structure of the functional locus at 16q13". Genomics. 8 (3): 513–8. doi:10.1016/0888-7543(90)90038-V. PMID   2286373.
• Gedamu L, Varshney U, Jahroudi N, et al. (1987). "Structure and Expression of the Human Metallothionein Genes". Metallothionein II. Experientia Supplementum. Vol. 52. pp. 361–72. doi:10.1007/978-3-0348-6784-9_34. ISBN   978-3-0348-6786-3. PMID   2444457.
• Varshney U, Jahroudi N, Foster R, Gedamu L (1987). "Structure, organization, and regulation of human metallothionein IF gene: differential and cell-type-specific expression in response to heavy metals and glucocorticoids". Mol. Cell. Biol. 6 (1): 26–37. doi:10.1128/MCB.6.1.26. PMC   367480 . PMID   3023827.
• Pauwels M, van Weyenbergh J, Soumillion A, et al. (1994). "Induction by zinc of specific metallothionein isoforms in human monocytes". Eur. J. Biochem. 220 (1): 105–10. doi: 10.1111/j.1432-1033.1994.tb18603.x . PMID   8119276.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID   12539042. S2CID   26145639.
• Huang Y, de la Chapelle A, Pellegata NS (2003). "Hypermethylation, but not LOH, is associated with the low expression of MT1G and CRABP1 in papillary thyroid carcinoma". Int. J. Cancer. 104 (6): 735–44. doi:10.1002/ijc.11006. PMID   12640681. S2CID   26461955.
• Cui YP, Wang JB, Zhang XY, et al. (2003). "Using yeast two-hybrid system to identify ECRG2 associated proteins and their possible interactions with ECRG2 gene". World J. Gastroenterol. 9 (9): 1892–6. doi: 10.3748/wjg.v9.i9.1892 . PMC   4656638 . PMID   12970870.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Joshi B, Ordonez-Ercan D, Dasgupta P, Chellappan S (2005). "Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors". Oncogene. 24 (13): 2204–17. doi: 10.1038/sj.onc.1208206 . PMID   15735762.
• Sun NN, Fastje CD, Wong SS, et al. (2005). "Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line". Toxicology and Industrial Health. 19 (7–10): 157–63. doi:10.1191/0748233703th185oa. PMID   15747776. S2CID   14394243.
• Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID   15862967. S2CID   9746088.