Michael J. Sailor

Last updated
Michael J. Sailor
Nationality American
Alma mater Harvey Mudd College (B.S., 1983)
Northwestern University (M.S., Ph.D. 1988)
Known forPorous silicon nanotechnology
Scientific career
Fields Nanotechnology, Porous silicon, Biomaterials
Institutions University of California, San Diego (1990–)

Michael J. Sailor is a nanotechnology researcher and professor at the University of California, San Diego. [1] Sailor is best known for his research on porous silicon, a nanostructured material that is prepared by electrochemical corrosion of crystalline silicon wafers. [2]

Contents

He pioneered the development of label-free biosensors from thin optical films of porous silicon. [3] He prepared the first microparticles and nanoparticles of porous silicon, [4] and harnessed the intrinsic photoluminescence of these formulations for in vitro and in vivo imaging applications. [5] He was the first to demonstrate time-gated luminescence imaging with these nanoparticles, [6] important because time-gating suppresses tissue autofluorescence that often compromises the fidelity of fluorescence images of biological tissues. He also adapted the concept of "Smart Dust" to the field of nanotechnology: the idea that microscopic particles can be manufactured with optical, chemical, and mechanical properties that can perform sensing, signaling, and motive functions. [7] [8] [9] [10]

Awards and honors

Sailor has received the following awards and honors:

Memberships

Sailor is a member of the following organizations and associations:

Related Research Articles

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Quantum dots (QDs) – also called semiconductor nanocrystals, are semiconductor particles a few nanometres in size, having optical and electronic properties that differ from those of larger particles as a result of quantum mechanics. They are a central topic in nanotechnology and materials science. When the quantum dots are illuminated by UV light, an electron in the quantum dot can be excited to a state of higher energy. In the case of a semiconducting quantum dot, this process corresponds to the transition of an electron from the valence band to the conductance band. The excited electron can drop back into the valence band releasing its energy as light. This light emission (photoluminescence) is illustrated in the figure on the right. The color of that light depends on the energy difference between the conductance band and the valence band, or the transition between discrete energy states when the band structure is no longer well-defined in QDs.

<span class="mw-page-title-main">Colloidal gold</span> Suspension of gold nanoparticles in a liquid

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<span class="mw-page-title-main">Nanoparticle</span> Particle with size less than 100 nm

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A nanocrystal is a material particle having at least one dimension smaller than 100 nanometres, based on quantum dots and composed of atoms in either a single- or poly-crystalline arrangement.

Hydrogen-terminated silicon surface is a chemically passivated silicon substrate where the surface Si atoms are bonded to hydrogen. The hydrogen-terminated surfaces are hydrophobic, luminescent, and amenable to chemical modification. Hydrogen-terminated silicon is an intermediate in the growth of bulk silicon from silane:

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Gold Nanocages are hollow, porous gold nanoparticles ranging in size from 10 to over 150 nm. They are created by reacting silver nanoparticles with chloroauric acid (HAuCl4) in boiling water. Whereas gold nanoparticles absorb light in the visible spectrum of light (at about 550 nm), gold nanocages absorb light in the near-infrared, where biological tissues absorb the least light. Because they are also biocompatible, gold nanocages are promising as a contrast agent for optical coherence tomography. Gold nanocages also absorb light and heat up (Photothermal effect), killing surrounding cancer cells. Nanocages have been functionalized with cancer-specific antibodies.

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<span class="mw-page-title-main">Warren Chan</span>

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Niveen M. Khashab is a Lebanese chemist and an associate Professor of chemical Sciences and engineering at King Abdullah University of Science and Technology in Saudi Arabia since 2009. She is a laureate of the 2017 L'Oréal-UNESCO Awards for Women in Science "for her contributions to innovative smart hybrid materials aimed at drug delivery and for developing new techniques to monitor intracellular antioxidant activity." She is also a fellow of the Royal Chemical Society, and a member of the American Chemical Society.

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References

  1. "Michael J. Sailor Biographical". UCSD Sailor Research Group. University of California, San Diego.
  2. Sailor, Michael J. (2012). Porous silicon in practice preparation, characterization and applications. Weinheim: Wiley-VCH. p. 249. ISBN   9783527313785.
  3. Lin, V.S.Y.; Motesharei, K.; Sailor, M. J.; Ghadiri, M. R. (31 October 1997). "A Porous Silicon-Based Optical Interferometric Biosensor". Science. 278 (5339): 840–843. Bibcode:1997Sci...278..840L. doi:10.1126/science.278.5339.840. PMID   9346478.
  4. Heinrich, J.L.; Curtis, C.L.; Credo, G.M.; Kavanagh, K.L.; Sailor, M.J. (3 January 1992). "Luminescent colloidal Si suspensions from porous Si". Science. 255 (5040): 66–68. doi:10.1126/science.255.5040.66. PMID   17739915. S2CID   19694068.
  5. Park, J.H.; Gu, L.; Rouslahti, E.; Bhatia, S.N.; Sailor, M.J. (22 February 2009). "Biodegradable luminescent porous silicon nanoparticles for in vivo applications". Nature Materials. 8 (4): 331–336. Bibcode:2009NatMa...8..331P. doi:10.1038/nmat2398. PMC   3058936 . PMID   19234444.
  6. Gu, L.; Hall, D.J.; Qin, Z.; Anglin, E.; Joo, J.; Mooney, D.J.; Howell, S.B.; Sailor, M.J. (12 August 2013). "In vivo time-gated fluorescence imaging with biodegradable luminescent porous silicon nanoparticles". Nature Communications. 4: 2326. Bibcode:2013NatCo...4.2326G. doi:10.1038/ncomms3326. PMC   4154512 . PMID   23933660.
  7. Sailor, M.J.; Link, J.R. (10 Feb 2005). "Smart Dust: nanostructured devices in a grain of sand". Chemical Communications (11): 1375–1383. doi:10.1039/b417554a. PMID   15756310.
  8. Dovree, J.R.; Derfus, A.M.; Bhatia, S.N.; Sailor, M.J. (7 November 2004). "Manipulation of liquid droplets using amphiphilic, magnetic 1-D photonic crystal chaperones". Nature Materials. 3 (12): 896–899. doi:10.1038/nmat1253. PMID   15531887. S2CID   8177935.
  9. Link, J.R.; Sailor, M.J. (June 19, 2003). "Smart Dust: Self-assembling, self-orienting photonic crystals of porous Si". Proceedings of the National Academy of Sciences. 100 (19): 10607–10610. Bibcode:2003PNAS..10010607L. doi: 10.1073/pnas.1233824100 . PMC   196851 . PMID   12947036.
  10. Schmedake, T.A.; Cunin, F.; Link, J.R.; Sailor, M.J. (16 September 2002). "Standoff detection of chemicals using porous silicon 'Smart Dust' particles". Advanced Materials. 14 (18): 1270–1272. doi:10.1002/1521-4095(20020916)14:18<1270::AID-ADMA1270>3.0.CO;2-R.
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  16. Paiva, Rini. "2003 winners of Collegiate Inventors Competition announced in NYC". EurekAlert.
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